Search Results - "Fong, Lawrence"

Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory by Poggio, Mauro, Hu, Tianyi, Pai, Chien-Chun, Chu, Brandon, Belair, Cassandra D., Chang, Anthony, Montabana, Elizabeth, Lang, Ursula E., Fu, Qi, Fong, Lawrence, Blelloch, Robert

“…PD-L1 on the surface of tumor cells binds its receptor PD-1 on effector T cells, thereby suppressing their activity. Antibody blockade of PD-L1 can activate an…”
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When intangible cultural heritage meets modernization–Can Chinese opera with modernized elements attract young festival-goers? by Li, Shanshi, Li, ShiNa, Nang Fong, Lawrence Hoc, Li, Yiqi

“…Although festivals centered around intangible cultural heritage (ICH) remain pivotal attractions for tourism destinations, the enduring appeal of Chinese opera…”
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Tourist–Host Identity Risk: Scale Development and Consequences by Fong, Lawrence Hoc Nang, Zhang, Carol Xiaoyue, Wang, Ziyou

“…Risk perception has been an important construct in understanding tourists’ trip planning. Surprisingly, while tourists’ perceived tourist–host identity risk…”
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Anti–Cytotoxic T-Lymphocyte Antigen-4 Antibody: The First in an Emerging Class of Immunomodulatory Antibodies for Cancer Treatment by FONG, Lawrence, SMALL, Eric J

“…To evaluate the emerging role of immunomodulatory antibodies in cancer treatment. Antibodies (ipilimumab and tremelimumab) targeting cytotoxic T-lymphocyte…”
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Immunotherapy in hepatocellular carcinoma: the complex interface between inflammation, fibrosis, and the immune response by Keenan, Bridget P., Fong, Lawrence, Kelley, Robin K.

“…Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide and confers a poor prognosis. Beyond standard systemic therapy with…”
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Single-cell RNA-seq reveals cell type-specific molecular and genetic associations to lupus by Perez, Richard K, Gordon, M Grace, Subramaniam, Meena, Kim, Min Cheol, Hartoularos, George C, Targ, Sasha, Sun, Yang, Ogorodnikov, Anton, Bueno, Raymund, Lu, Andrew, Thompson, Mike, Rappoport, Nadav, Dahl, Andrew, Lanata, Cristina M, Matloubian, Mehrdad, Maliskova, Lenka, Kwek, Serena S, Li, Tony, Slyper, Michal, Waldman, Julia, Dionne, Danielle, Rozenblatt-Rosen, Orit, Fong, Lawrence, Dall'Era, Maria, Balliu, Brunilda, Regev, Aviv, Yazdany, Jinoos, Criswell, Lindsey A, Zaitlen, Noah, Ye, Chun Jimmie

“…Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease. Knowledge of circulating immune cell types and states associated with SLE remains…”
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Targeting EZH2 Reprograms Intratumoral Regulatory T Cells to Enhance Cancer Immunity by Wang, David, Quiros, Jason, Mahuron, Kelly, Pai, Chien-Chun, Ranzani, Valeria, Young, Arabella, Silveria, Stephanie, Harwin, Tory, Abnousian, Arbi, Pagani, Massimiliano, Rosenblum, Michael D., Van Gool, Frederic, Fong, Lawrence, Bluestone, Jeffrey A., DuPage, Michel

“…Regulatory T cells (Tregs) are critical for maintaining immune homeostasis, but their presence in tumor tissues impairs anti-tumor immunity and portends poor…”
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Immunomodulatory Activity of Nivolumab in Metastatic Renal Cell Carcinoma by Choueiri, Toni K, Fishman, Mayer N, Escudier, Bernard, McDermott, David F, Drake, Charles G, Kluger, Harriet, Stadler, Walter M, Perez-Gracia, Jose Luis, McNeel, Douglas G, Curti, Brendan, Harrison, Michael R, Plimack, Elizabeth R, Appleman, Leonard, Fong, Lawrence, Albiges, Laurence, Cohen, Lewis, Young, Tina C, Chasalow, Scott D, Ross-Macdonald, Petra, Srivastava, Shivani, Jure-Kunkel, Maria, Kurland, John F, Simon, Jason S, Sznol, Mario

“…Nivolumab, an anti-PD-1 immune checkpoint inhibitor, improved overall survival versus everolimus in a phase 3 trial of previously treated patients with…”
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Big data use in determining competitive position: The case of theme parks in Hong Kong by Albayrak, Tahir, Cengizci, Aslıhan Dursun, Caber, Meltem, Nang Fong, Lawrence Hoc

“…Theme park operators need to understand their competitiveness in a destination to increase their market share. This study adopted the big data approach by…”
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Adenosine 2A Receptor Blockade as an Immunotherapy for Treatment-Refractory Renal Cell Cancer by Fong, Lawrence, Hotson, Andrew, Powderly, John D, Sznol, Mario, Heist, Rebecca S, Choueiri, Toni K, George, Saby, Hughes, Brett G M, Hellmann, Matthew D, Shepard, Dale R, Rini, Brian I, Kummar, Shivaani, Weise, Amy M, Riese, Matthew J, Markman, Ben, Emens, Leisha A, Mahadevan, Daruka, Luke, Jason J, Laport, Ginna, Brody, Joshua D, Hernandez-Aya, Leonel, Bonomi, Philip, Goldman, Jonathan W, Berim, Lyudmyla, Renouf, Daniel J, Goodwin, Rachel A, Munneke, Brian, Ho, Po Y, Hsieh, Jessica, McCaffery, Ian, Kwei, Long, Willingham, Stephen B, Miller, Richard A

“…Adenosine mediates immunosuppression within the tumor microenvironment through triggering adenosine 2A receptors (A2AR) on immune cells. To determine whether…”
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How does celebrity involvement influence travel intention? The case of promoting Chengdu on TikTok by Zhu, Chris, Hoc Nang Fong, Lawrence, Gao, Huicai, Buhalis, Dimitrios, Shang, Ziye

“…This study examines the predicting effect of celebrity involvement on destination authenticity (object-based authenticity and existential authenticity) and…”
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Immunotherapy for Prostate Cancer: Biology and Therapeutic Approaches by CHA, Edward, FONG, Lawrence

“…Although prostate cancer was not historically considered to be a particularly immune-responsive cancer, recent clinical trials have demonstrated that…”
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Next steps for clinical translation of adenosine pathway inhibition in cancer immunotherapy by Augustin, Ryan C., Leone, Robert D., Naing, Aung, Fong, Lawrence, Bao, Riyue, Luke, Jason J.

“…Increasing evidence supports targeting the adenosine pathway in immuno-oncology with several clinical programs directed at adenosine A2 receptor (A2AR, A2BR),…”
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Microfluidic-Based Multiplex qRT-PCR Identifies Diagnostic and Prognostic microRNA Signatures in the Sera of Prostate Cancer Patients by MOLTZAHN, Felix, OLSHEN, AdamB, BAEHNER, Lauren, PEEK, Andrew, FONG, Lawrence, STÖPPLER, Hubert, SIMKO, Jeffry, HILTON, Joan F, CARROLL, Peter, BLELLOCH, Robert

“…Recent prostate-specific antigen-based screening trials indicate an urgent need for novel and noninvasive biomarker identification strategies to improve the…”
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Vaccinating against cancer: getting to prime time by Chang, Ryan, Gulley, James L, Fong, Lawrence

“…Immunotherapies, such as immune checkpoint inhibitors, cellular therapies, and T-cell engagers, have fundamentally changed our approach to treating cancer…”
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Immune evasion mediated by tumor-derived lactate dehydrogenase induction of NKG2D ligands on myeloid cells in glioblastoma patients by Crane, Courtney A., Austgen, Kathryn, Haberthur, Kristen, Hofmann, Carly, Moyes, Kara White, Avanesyan, Lia, Fong, Lawrence, Campbell, Michael J., Cooper, Stewart, Oakes, Scott A., Parsa, Andrew T., Lanier, Lewis L.

“…Myeloid cells are key regulators of the tumor microenvironment, governing local immune responses. Here we report that tumor-infiltrating myeloid cells and…”
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Editorial: Advancements in immunology and immunotherapy for breast cancer by Sugie, Tomoharu, Salgado, Roberto, Fong, Lawrence

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Health-Related Quality-of-Life Analysis From KEYNOTE-045: A Phase III Study of Pembrolizumab Versus Chemotherapy for Previously Treated Advanced Urothelial Cancer by Vaughn, David J, Bellmunt, Joaquim, Fradet, Yves, Lee, Jae Lyun, Fong, Lawrence, Vogelzang, Nicholas J, Climent, Miguel A, Petrylak, Daniel P, Choueiri, Toni K, Necchi, Andrea, Gerritsen, Winald, Gurney, Howard, Quinn, David I, Culine, Stephane, Sternberg, Cora N, Mai, Yabing, Li, Haojie, Perini, Rodolfo F, Bajorin, Dean F, de Wit, Ronald

“…Purpose In the phase III KEYNOTE-045 study ( ClinicalTrials.gov identifier: NCT02256436), pembrolizumab significantly prolonged overall survival compared with…”
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Phase I Clinical Trial of the CYP17 Inhibitor Abiraterone Acetate Demonstrating Clinical Activity in Patients With Castration-Resistant Prostate Cancer Who Received Prior Ketoconazole Therapy by Ryan, Charles J, Smith, Matthew R, Fong, Lawrence, Rosenberg, Jonathan E, Kantoff, Philip, Raynaud, Florence, Martins, Vanessa, Lee, Gloria, Kheoh, Thian, Kim, Jennifer, Molina, Arturo, Small, Eric J

“…Abiraterone acetate is a prodrug of abiraterone, a selective inhibitor of CYP17, the enzyme catalyst for two essential steps in androgen biosynthesis. In…”
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TCR Convergence in Individuals Treated With Immune Checkpoint Inhibition for Cancer by Looney, Timothy John, Topacio-Hall, Denise, Lowman, Geoffrey, Conroy, Jeffrey, Morrison, Carl, Oh, David, Fong, Lawrence, Zhang, Li

“…Tumor antigen-driven selection may expand T cells having T cell receptors (TCRs) of shared antigen specificity but different amino acid or nucleotide sequence…”
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