Search Results - "Fong, Jerry J"

Siglec-14 Enhances NLRP3-Inflammasome Activation in Macrophages by Tsai, Chih-Ming, Riestra, Angelica M., Ali, Syed Raza, Fong, Jerry J., Liu, Janet Z., Hughes, Gillian, Varki, Ajit, Nizet, Victor

“…Pathogenic microorganisms are sensed by the inflammasome, resulting in the release of the pro-immune and proinflammatory cytokine interleukin-1β (IL-1β). In…”
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Immunomodulatory activity of extracellular Hsp70 mediated via paired receptors Siglec-5 and Siglec-14 by Fong, Jerry J, Sreedhara, Karthik, Deng, Liwen, Varki, Nissi M, Angata, Takashi, Liu, Qinglian, Nizet, Victor, Varki, Ajit

“…The intracellular chaperone heat‐shock protein 70 (Hsp70) can be secreted from cells, but its extracellular role is unclear, as the protein has been reported…”
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Human-specific evolutionary changes in the biology of siglecs by Schwarz, Flavio, Fong, Jerry J, Varki, Ajit

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Evolution of the exclusively human pathogen Neisseria gonorrhoeae: Human‐specific engagement of immunoregulatory Siglecs by Landig, Corinna S., Hazel, Ashley, Kellman, Benjamin P., Fong, Jerry J., Schwarz, Flavio, Agarwal, Sarika, Varki, Nissi, Massari, Paola, Lewis, Nathan E., Ram, Sanjay, Varki, Ajit

“…Neisseria gonorrhoeae causes the sexually transmitted disease gonorrhea exclusively in humans and uses multiple strategies to infect, including acquisition of…”
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Siglec-5 and Siglec-14 are polymorphic paired receptors that modulate neutrophil and amnion signaling responses to group B Streptococcus by Ali, Syed Raza, Fong, Jerry J, Carlin, Aaron F, Busch, Tamara D, Linden, Rebecka, Angata, Takashi, Areschoug, Thomas, Parast, Mana, Varki, Nissi, Murray, Jeffrey, Nizet, Victor, Varki, Ajit

“…Group B Streptococcus (GBS) causes invasive infections in human newborns. We recently showed that the GBS β-protein attenuates innate immune responses by…”
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Siglec-7 engagement by GBS β-protein suppresses pyroptotic cell death of natural killer cells by Fong, Jerry J., Tsai, Chih-Ming, Saha, Sudeshna, Nizet, Victor, Varki, Ajit, Bui, Jack D.

“…Natural killer (NK) cells are innate immune lymphocytes that recognize and destroy abnormal host cells, such as tumor cells or those infected by viral…”
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Cancer-targeted photoimmunotherapy induces antitumor immunity and can be augmented by anti-PD-1 therapy for durable anticancer responses in an immunologically active murine tumor model by Hsu, Michelle A., Okamura, Stephanie M., De Magalhaes Filho, C. Daniel, Bergeron, Daniele M., Rodriguez, Ahiram, West, Melissa, Yadav, Deepak, Heim, Roger, Fong, Jerry J., Garcia-Guzman, Miguel

“…The complex immunosuppressive nature of solid tumor microenvironments poses a significant challenge to generating efficacious and durable anticancer responses…”
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β-N-Acetylglucosamine (O-GlcNAc) Is a Novel Regulator of Mitosis-specific Phosphorylations on Histone H3 by Fong, Jerry J., Nguyen, Brenda L., Bridger, Robert, Medrano, Estela E., Wells, Lance, Pan, Shujuan, Sifers, Richard N.

“…O-Linked β-N-acetylglucosamine, or O-GlcNAc, is a dynamic post-translational modification that cycles on and off serine and threonine residues of…”
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Expansion of intestinal stem cells associated with long-term adaptation following ileocecal resection in mice by Dekaney, Christopher M, Fong, Jerry J, Rigby, Rachael J, Lund, P Kay, Henning, Susan J, Helmrath, Michael A

“…Sustained increases in mucosal surface area occur in remaining bowel following massive intestinal loss. The mechanisms responsible for expanding and…”
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The SIGLEC14 null allele is associated with Mycobacterium tuberculosis- and BCG-induced clinical and immunologic outcomes by Graustein, Andrew D, Horne, David J, Fong, Jerry J, Schwarz, Flavio, Mefford, Heather C, Peterson, Glenna J, Wells, Richard D, Musvosvi, Munyaradzi, Shey, Muki, Hanekom, Willem A, Hatherill, Mark, Scriba, Thomas J, Thuong, Nguyen Thuy Thuong, Mai, Nguyen Thi Hoang, Caws, Maxine, Bang, Nguyen Duc, Dunstan, Sarah J, Thwaites, Guy E, Varki, Ajit, Angata, Takashi, Hawn, Thomas R

“…Abstract Humans exposed to Mycobacterium tuberculosis (Mtb) have variable susceptibility to tuberculosis (TB) and its outcomes. Siglec-5 and Siglec-14 are…”
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Rapid expansion of intestinal secretory lineages following a massive small bowel resection in mice by Helmrath, Michael A, Fong, Jerry J, Dekaney, Christopher M, Henning, Susan J

“…Following massive small bowel resection (SBR) in mice, there are sustained increases in crypt depth and villus height, resulting in enhanced mucosal surface…”
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Abstract 1796: PD-L1 photoimmunotherapy kills immunosuppressive myeloid cells to activate local and systemic antitumor immunity in syngeneic mouse models by Thorne, Amy H., Hsu, Michelle H., Mendoza, Daniel, Lapetoda, Jason, Parry, Christopher M., Fong, Jerry J., Garcia-Guzman, Miguel

“…Introduction: Photoimmunotherapy is an investigational anticancer treatment platform that combines the cell surface binding of an antibody conjugated to a…”
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Abstract 1798: CTLA-4 photoimmunotherapy depletes intratumoral regulatory T cells (Tregs) to augment local and systemic immunity for anticancer activity by Filho, C. Daniel de Magalhaes, Okamura, Stephanie M., Bergeron, Daniele M., Rodriguez, Ahiram, Lozano, Abram, Fong, Jerry J., Garcia-Guzman, Miguel

“…Introduction: Photoimmunotherapy is an investigational cancer treatment platform that utilizes an antibody conjugated to a light activated dye IRDye® 700DX…”
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Abstract 3734: Cancer cell-targeted photoimmunotherapy elicits immunogenic cell death and activates the innate and adaptive immune response in the tumor microenvironment by Hsu, Michelle A., Okamura, Stephanie M., Bergeron, Daniele M., Yadav, Deepak, Fong, Jerry J., Heim, Roger, Garcia-Guzman, Miguel

“…INTRODUCTION: Cancer cell-targeted photoimmunotherapy (PIT) is a platform technology under development for the treatment of various cancers. PIT is a drug +…”
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Abstract 949: Anti-cancer activity by photoimmunotherapy is driven by adaptive immune responses and vaccinates the host against the tumor by De Magalhaes Filho, C. Daniel, Hsu, Michelle A., Okamura, Stephanie M., Gitnick, Dany, Solis, Estela, Fong, Jerry J., Garcia-Guzman, Miguel

“…INTRODUCTION: Photoimmunotherapy (PIT) is an investigational anti-cancer treatment platform utilizing cell-targeted antibodies conjugated to the IR700 (IRDye…”
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Abstract 2255: Combination treatment of cancer cell-targeted photoimmunotherapy plus anti-PD1 leads to synergistic anticancer activity in an immunocompetent mouse model by Okamura, Stephanie M., Hsu, Michelle A., Bergeron, Daniele M., Solis, Estela, Yadav, Deepak, Fong, Jerry J., Heim, Roger, Garcia-Guzman, Miguel

“…INTRODUCTION: Photoimmunotherapy (PIT) is a new cancer-targeted platform technology that utilizes a photoactivatable dye (IRDye 700DX) conjugated to a…”
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