Search Results - "Fondufe‐Mittendorf, Yvonne N."

The multifaceted role of PARP1 in RNA biogenesis by Eleazer, Rebekah, Fondufe‐Mittendorf, Yvonne N.

“…Poly(ADP‐ribose) polymerases (PARPs) are abundant nuclear proteins that synthesize ADP ribose polymers (pADPr) and catalyze the addition of (p)ADPr to target…”
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Controls of nucleosome positioning in the human genome by Gaffney, Daniel J, McVicker, Graham, Pai, Athma A, Fondufe-Mittendorf, Yvonne N, Lewellen, Noah, Michelini, Katelyn, Widom, Jonathan, Gilad, Yoav, Pritchard, Jonathan K

“…Nucleosomes are important for gene regulation because their arrangement on the genome can control which proteins bind to DNA. Currently, few human nucleosomes…”
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Exploring the interplay between PARP1 and circRNA biogenesis and function by Dhahri, Hejer, Fondufe-Mittendorf, Yvonne N

“…PARP1 (poly-ADP-ribose polymerase 1) is a multidomain protein with a flexible and self-folding structure that allows it to interact with a wide range of…”
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Genome-wide DNA methylation reprogramming in response to inorganic arsenic links inhibition of CTCF binding, DNMT expression and cellular transformation by Rea, Matthew, Eckstein, Meredith, Eleazer, Rebekah, Smith, Caroline, Fondufe-Mittendorf , Yvonne N.

“…Chronic low dose inorganic arsenic (iAs) exposure leads to changes in gene expression and epithelial-to-mesenchymal transformation. During this transformation,…”
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Co‐Targeting Plk1 and DNMT3a in Advanced Prostate Cancer by Zhang, Zhuangzhuang, Cheng, Lijun, Zhang, Qiongsi, Kong, Yifan, He, Daheng, Li, Kunyu, Rea, Matthew, Wang, Jianling, Wang, Ruixin, Liu, Jinghui, Li, Zhiguo, Yuan, Chongli, Liu, Enze, Fondufe‐Mittendorf, Yvonne N., Li, Lang, Han, Tao, Wang, Chi, Liu, Xiaoqi

“…Because there is no effective treatment for late‐stage prostate cancer (PCa) at this moment, identifying novel targets for therapy of advanced PCa is urgently…”
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Co‐Targeting Plk1 and DNMT3a in Advanced Prostate Cancer by Zhang, Zhuangzhuang, Cheng, Lijun, Zhang, Qiongsi, Kong, Yifan, He, Daheng, Li, Kunyu, Rea, Matthew, Wang, Jianlin, Wang, Ruixin, Liu, Jinghui, Li, Zhiguo, Yuan, Chongli, Liu, Enze, Fondufe‐Mittendorf, Yvonne N., Li, Lang, Wang, Chi, Liu, Xiaoqi, Han, Tao

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Cooperative nucleic acid binding by Poly ADP-ribose polymerase 1 by Melikishvili, Manana, Fried, Michael G., Fondufe-Mittendorf, Yvonne N.

“…Poly (ADP)-ribose polymerase 1 (PARP1) is an abundant nuclear protein well-known for its role in DNA repair yet also participates in DNA replication,…”
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Beyond the Usual Suspects: Examining the Role of Understudied Histone Variants in Breast Cancer by Dhahri, Hejer, Saintilnord, Wesley N, Chandler, Darrell, Fondufe-Mittendorf, Yvonne N

“…The incorporation of histone variants has structural ramifications on nucleosome dynamics and stability. Due to their unique sequences, histone variants can…”
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Genome-Wide Profiling of PARP1 Reveals an Interplay with Gene Regulatory Regions and DNA Methylation by Nalabothula, Narasimharao, Al-jumaily, Taha, Eteleeb, Abdallah M, Flight, Robert M, Xiaorong, Shao, Moseley, Hunter, Rouchka, Eric C, Fondufe-Mittendorf, Yvonne N

“…Poly (ADP-ribose) polymerase-1 (PARP1) is a nuclear enzyme involved in DNA repair, chromatin remodeling and gene expression. PARP1 interactions with chromatin…”
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Latexin regulation by HMGB2 is required for hematopoietic stem cell maintenance by Zhang, Cuiping, Fondufe-Mittendorf, Yvonne N, Wang, Chi, Chen, Jin, Cheng, Qiang, Zhou, Daohong, Zheng, Yi, Geiger, Hartmut, Liang, Ying

“…Hematopoietic stem cells provide life-long production of blood cells and undergo self-renewal division in order to sustain the stem cell pool. Homeostatic…”
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Coupling of PARP1-mediated chromatin structural changes to transcriptional RNA polymerase II elongation and cotranscriptional splicing by Matveeva, Elena A, Al-Tinawi, Qamar M H, Rouchka, Eric C, Fondufe-Mittendorf, Yvonne N

“…Recently, we showed that PARP1 is involved in cotranscriptional splicing, possibly by bridging chromatin to RNA and recruiting splicing factors. It also can…”
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Transcriptional Regulation Factors of the Human Mitochondrial Aspartate/Glutamate Carrier Gene, Isoform 2 ( SLC25A13 ): USF1 as Basal Factor and FOXA2 as Activator in Liver Cells by Convertini, Paolo, Todisco, Simona, De Santis, Francesco, Pappalardo, Ilaria, Iacobazzi, Dominga, Castiglione Morelli, Maria Antonietta, Fondufe-Mittendorf, Yvonne N, Martelli, Giuseppe, Palmieri, Ferdinando, Infantino, Vittoria

“…Mitochondrial carriers catalyse the translocation of numerous metabolites across the inner mitochondrial membrane, playing a key role in different cell…”
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Quantitative Mass Spectrometry Reveals Changes in Histone H2B Variants as Cells Undergo Inorganic Arsenic-Mediated Cellular Transformation by Rea, Matthew, Jiang, Tingting, Eleazer, Rebekah, Eckstein, Meredith, Marshall, Alan G., Fondufe-Mittendorf, Yvonne N.

“…Exposure to inorganic arsenic, a ubiquitous environmental toxic metalloid, leads to carcinogenesis. However, the mechanism is unknown. Several studies have…”
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Archaeal nucleosome positioning in vivo and in vitro is directed by primary sequence motifs by Nalabothula, Narasimharao, Xi, Liqun, Bhattacharyya, Sucharita, Widom, Jonathan, Wang, Ji-Ping, Reeve, John N, Santangelo, Thomas J, Fondufe-Mittendorf, Yvonne N

“…Histone wrapping of DNA into nucleosomes almost certainly evolved in the Archaea, and predates Eukaryotes. In Eukaryotes, nucleosome positioning plays a…”
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A comparison of nucleosome organization in Drosophila cell lines by Martin, Rebecca L, Maiorano, John, Beitel, Greg J, Marko, John F, McVicker, Graham, Fondufe-Mittendorf, Yvonne N

“…Changes in the distribution of nucleosomes along the genome influence chromatin structure and impact gene expression by modulating the accessibility of DNA to…”
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Involvement of PARP1 in the regulation of alternative splicing by Matveeva, Elena, Maiorano, John, Zhang, Qingyang, Eteleeb, Abdallah M, Convertini, Paolo, Chen, Jing, Infantino, Vittoria, Stamm, Stefan, Wang, Jiping, Rouchka, Eric C, Fondufe-Mittendorf, Yvonne N

“…Specialized chromatin structures such as nucleosomes with specific histone modifications decorate exons in eukaryotic genomes, suggesting a functional…”
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Microarray dataset of transient and permanent DNA methylation changes in HeLa cells undergoing inorganic arsenic-mediated epithelial-to-mesenchymal transition by Eckstein, Meredith, Rea, Matthew, Fondufe-Mittendorf, Yvonne N.

“…The novel dataset presented here represents the results of the changing pattern of DNA methylation profiles in HeLa cells exposed to chronic low dose (0.5µM)…”
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Transient and permanent changes in DNA methylation patterns in inorganic arsenic-mediated epithelial-to-mesenchymal transition by Eckstein, Meredith, Rea, Matthew, Fondufe-Mittendorf, Yvonne N.

“…Chronic low dose inorganic arsenic exposure causes cells to take on an epithelial-to-mesenchymal phenotype, which is a crucial process in carcinogenesis…”
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A dynamic model of inorganic arsenic-induced carcinogenesis reveals an epigenetic mechanism for epithelial–mesenchymal plasticity by Rea, Matthew, Kimmerer, Greg, Mittendorf, Shania, Xiong, Xiaopeng, Green, Meghan, Chandler, Darrell, Saintilnord, Wesley, Blackburn, Jessica, Gao, Tianyan, Fondufe-Mittendorf, Yvonne N.

“…Inorganic arsenic (iAs) causes cancer by initiating dynamic transitions between epithelial and mesenchymal cell phenotypes. These transitions transform normal…”
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PARP1 is a versatile factor in the regulation of mRNA stability and decay by Matveeva, Elena A., Mathbout, Lein F., Fondufe-Mittendorf, Yvonne N.

“…PARP1 is an abundant nuclear protein with many pleiotropic functions involved in epigenetic and transcriptional controls. Abundance of mRNA depends on the…”
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