Search Results - "Fondevila, Marcos F."

O -GlcNAcylation: A Sweet Hub in the Regulation of Glucose Metabolism in Health and Disease by Gonzalez-Rellan, Maria J, Fondevila, Marcos F, Dieguez, Carlos, Nogueiras, Ruben

“…-GlcNAcylation is a posttranslational modification ruled by the activity of a single pair of enzymes, -GlcNAc transferase (OGT) and -GlcNAcase (OGA). These two…”
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Inhibition of hepatic p63 ameliorates steatohepatitis with fibrosis in mice by Fondevila, Marcos F., Novoa, Eva, Fernandez, Uxia, Dorta, Valentina, Parracho, Tamara, Kreimeyer, Henriette, Garcia-Vence, Maria, Chantada-Vazquez, Maria P., Bravo, Susana B., Porteiro, Begoña, Cabaleiro, Alba, Koning, Mijra, Senra, Ana, Souto, Yara, Verheij, Joanne, Guallar, Diana, Fidalgo, Miguel, Meijnikman, Abraham S., da Silva Lima, Natalia, Dieguez, Carlos, Gonzalez-Rellan, Maria J., Nogueiras, Ruben

“…p63 is a transcription factor involved in multiple biological functions. In the liver, the TAp63 isoform induces lipid accumulation in hepatocytes. However,…”
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Hepatocyte-specific O-GlcNAc transferase downregulation ameliorates nonalcoholic steatohepatitis by improving mitochondrial function by Gonzalez-Rellan, Maria J., Parracho, Tamara, Heras, Violeta, Rodriguez, Amaia, Fondevila, Marcos F., Novoa, Eva, Lima, Natalia, Varela-Rey, Marta, Senra, Ana, Chantada-Vazquez, Maria D.P., Ameneiro, Cristina, Bernardo, Ganeko, Fernandez-Ramos, David, Lopitz-Otsoa, Fernando, Bilbao, Jon, Guallar, Diana, Fidalgo, Miguel, Bravo, Susana, Dieguez, Carlos, Martinez-Chantar, Maria L., Millet, Oscar, Mato, Jose M., Schwaninger, Markus, Prevot, Vincent, Crespo, Javier, Frühbeck, Gema, Iruzubieta, Paula, Nogueiras, Ruben

“…O-GlcNAcylation is a post-translational modification that directly couples the processes of nutrient sensing, metabolism, and signal transduction, affecting…”
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Pharmacological stimulation of p53 with low-dose doxorubicin ameliorates diet-induced nonalcoholic steatosis and steatohepatitis by Porteiro, Begoña, Fondevila, Marcos F, Buque, Xabier, Gonzalez-Rellan, Maria J, Fernandez, Uxia, Mora, Alfonso, Beiroa, Daniel, Senra, Ana, Gallego, Rosalia, Fernø, Johan, López, Miguel, Sabio, Guadalupe, Dieguez, Carlos, Aspichueta, Patricia, Nogueiras, Rubén

“…Recent reports have implicated the p53 tumor suppressor in the regulation of lipid metabolism. We hypothesized that the pharmacological activation of p53 with…”
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Intestinal clock modulates rhythmic hepatic metabolism by Fondevila, Marcos F., Schnabl, Bernd

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The central role of the gut microbiota in the pathophysiology and management of type 2 diabetes by Baars, Daniel P, Fondevila, Marcos F, Meijnikman, Abraham S, Nieuwdorp, Max

“…The inhabitants of our intestines, collectively called the gut microbiome, comprise fungi, viruses, and bacterial strains. These microorganisms are involved in…”
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Obese patients with NASH have increased hepatic expression of SARS-CoV-2 critical entry points by Fondevila, Marcos F., Mercado-Gómez, Maria, Rodríguez, Amaia, Gonzalez-Rellan, Maria J., Iruzubieta, Paula, Valentí, Víctor, Escalada, Javier, Schwaninger, Markus, Prevot, Vincent, Dieguez, Carlos, Crespo, Javier, Frühbeck, Gema, Martinez-Chantar, Maria L., Nogueiras, Ruben

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Inhibition of carnitine palmitoyltransferase 1A in hepatic stellate cells protects against fibrosis by Fondevila, Marcos F., Fernandez, Uxia, Heras, Violeta, Parracho, Tamara, Gonzalez-Rellan, Maria J., Novoa, Eva, Porteiro, Begoña, Alonso, Cristina, Mayo, Rebeca, da Silva Lima, Natalia, Iglesias, Cristina, Filliol, Aveline A., Senra, Ana, Delgado, Teresa C., Woodhoo, Ashwin, Herrero, Laura, Serra, Dolors, Prevot, Vincent, Schwaninger, Markus, López, Miguel, Dieguez, Carlos, Millet, Oscar, Mato, Jose M., Cubero, Francisco J., Varela-Rey, Marta, Iruzubieta, Paula, Crespo, Javier, Martinez-Chantar, Maria L., Schwabe, Robert F., Nogueiras, Ruben

“…The pathogenesis of liver fibrosis requires activation of hepatic stellate cells (HSCs); once activated, HSCs lose intracellular fatty acids but the role of…”
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O-GlcNAcylated p53 in the liver modulates hepatic glucose production by Gonzalez-Rellan, Maria J., Fondevila, Marcos F., Fernandez, Uxia, Rodríguez, Amaia, Varela-Rey, Marta, Veyrat-Durebex, Christelle, Seoane, Samuel, Bernardo, Ganeko, Lopitz-Otsoa, Fernando, Fernández-Ramos, David, Bilbao, Jon, Iglesias, Cristina, Novoa, Eva, Ameneiro, Cristina, Senra, Ana, Beiroa, Daniel, Cuñarro, Juan, DP Chantada-Vazquez, Maria, Garcia-Vence, Maria, Bravo, Susana B., Da Silva Lima, Natalia, Porteiro, Begoña, Carneiro, Carmen, Vidal, Anxo, Tovar, Sulay, Müller, Timo D., Ferno, Johan, Guallar, Diana, Fidalgo, Miguel, Sabio, Guadalupe, Herzig, Stephan, Yang, Won Ho, Cho, Jin Won, Martinez-Chantar, Maria Luz, Perez-Fernandez, Roman, López, Miguel, Dieguez, Carlos, Mato, Jose M., Millet, Oscar, Coppari, Roberto, Woodhoo, Ashwin, Fruhbeck, Gema, Nogueiras, Ruben

“…p53 regulates several signaling pathways to maintain the metabolic homeostasis of cells and modulates the cellular response to stress. Deficiency or excess of…”
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Splicing factor SF3B1 is overexpressed and implicated in the aggressiveness and survival of hepatocellular carcinoma by López-Cánovas, Juan L., del Rio-Moreno, Mercedes, García-Fernandez, Helena, Jiménez-Vacas, Juan M., Moreno-Montilla, M.Trinidad, Sánchez-Frias, Marina E., Amado, Víctor, L-López, Fernando, Fondevila, Marcos F., Ciria, Rubén, Gómez-Luque, Irene, Briceño, Javier, Nogueiras, Rubén, de la Mata, Manuel, Castaño, Justo P., Rodriguez-Perálvarez, Manuel, Luque, Raúl M., Gahete, Manuel D.

“…Splicing alterations represent an actionable cancer hallmark. Splicing factor 3B subunit 1 (SF3B1) is a crucial splicing factor that can be targeted…”
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Hepatic p63 regulates glucose metabolism by repressing SIRT1 by Gonzalez-Rellan, Maria J, Novoa, Eva, da Silva Lima, Natalia, Rodriguez, Amaia, Veyrat-Durebex, Christelle, Seoane, Samuel, Porteiro, Begoña, Fondevila, Marcos F, Fernandez, Uxia, Varela-Rey, Marta, Senra, Ana, Iglesias, Cristina, Escudero, Adriana, Fidalgo, Miguel, Guallar, Diana, Perez-Fernandez, Roman, Prevot, Vincent, Schwaninger, Markus, López, Miguel, Dieguez, Carlos, Coppari, Roberto, Frühbeck, Gema, Nogueiras, Ruben

“…p63 is a transcription factor within the p53 protein family that has key roles in development, differentiation and prevention of senescence, but its metabolic…”
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Inhibition of ATG3 ameliorates liver steatosis by increasing mitochondrial function by da Silva Lima, Natália, Fondevila, Marcos F., Nóvoa, Eva, Buqué, Xabier, Mercado-Gómez, Maria, Gallet, Sarah, González-Rellan, Maria J., Fernandez, Uxia, Loyens, Anne, Garcia-Vence, Maria, Chantada-Vazquez, Maria del Pilar, Bravo, Susana B., Marañon, Patricia, Senra, Ana, Escudero, Adriana, Leiva, Magdalena, Guallar, Diana, Fidalgo, Miguel, Gomes, Pedro, Claret, Marc, Sabio, Guadalupe, Varela-Rey, Marta, Delgado, Teresa C., Montero-Vallejo, Rocio, Ampuero, Javier, López, Miguel, Diéguez, Carlos, Herrero, Laura, Serra, Dolors, Schwaninger, Markus, Prevot, Vincent, Gallego-Duran, Rocio, Romero-Gomez, Manuel, Iruzubieta, Paula, Crespo, Javier, Martinez-Chantar, Maria L., Garcia-Monzon, Carmelo, Gonzalez-Rodriguez, Agueda, Aspichueta, Patricia, Nogueiras, Ruben

“…Autophagy-related gene 3 (ATG3) is an enzyme mainly known for its actions in the LC3 lipidation process, which is essential for autophagy. Whether ATG3 plays a…”
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Neddylation of phosphoenolpyruvate carboxykinase 1 controls glucose metabolism by Gonzalez-Rellan, María J, Fernández, Uxía, Parracho, Tamara, Novoa, Eva, Fondevila, Marcos F, da Silva Lima, Natalia, Ramos, Lucía, Rodríguez, Amaia, Serrano-Maciá, Marina, Perez-Mejias, Gonzalo, Chantada-Vazquez, Pilar, Riobello, Cristina, Veyrat-Durebex, Christelle, Tovar, Sulay, Coppari, Roberto, Woodhoo, Ashwin, Schwaninger, Markus, Prevot, Vincent, Delgado, Teresa C, Lopez, Miguel, Diaz-Quintana, Antonio, Dieguez, Carlos, Guallar, Diana, Frühbeck, Gema, Diaz-Moreno, Irene, Bravo, Susana B, Martinez-Chantar, Maria L, Nogueiras, Ruben

“…Neddylation is a post-translational mechanism that adds a ubiquitin-like protein, namely neural precursor cell expressed developmentally downregulated protein…”
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Mitochondrial antiviral signaling protein enhances MASLD progression through the ERK/TNFα/NFκβ pathway by Nóvoa, Eva, da Silva Lima, Natália, Gonzalez-Rellan, Maria J., Chantada-Vazquez, Maria D.P., Verheij, Joanne, Rodriguez, Amaia, Esquinas-Roman, Eva M., Fondevila, Marcos F., Koning, Mirja, Fernandez, Uxia, Cabaleiro, Alba, Parracho, Tamara, Iglesias-Moure, Jose, Seoane, Samuel, Porteiro, Begoña, Escudero, Adriana, Senra, Ana, Perez-Fernandez, Roman, López, Miguel, Fidalgo, Miguel, Guallar, Diana, Martinez-Chantar, Maria L., Dieguez, Carlos, Varela-Rey, Marta, Prevot, Vincent, Schwaninger, Markus, Meijnikman, Abraham, Bravo, Susana B., Frühbeck, Gema, Nogueiras, Ruben

“…Background and Aims: Mitochondrial antiviral signaling protein (MAVS) is a critical regulator that activates the host’s innate immunity against RNA viruses,…”
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Mitochondrial antiviral signaling protein enhances MASLD progression via the ERK/TNFα/NFκβ pathway by Nóvoa, Eva, da Silva Lima, Natália, Gonzalez-Rellan, Maria J, Chantada-Vazquez, Maria D P, Verheij, Joanne, Rodriguez, Amaia, Esquinas-Roman, Eva M, Fondevila, Marcos F, Koning, Mirja, Fernandez, Uxia, Cabaleiro, Alba, Parracho, Tamara, Iglesias-Moure, Jose, Seoane, Samuel, Porteiro, Begoña, Escudero, Adriana, Senra, Ana, Perez-Fernandez, Roman, López, Miguel, Fidalgo, Miguel, Guallar, Diana, Martinez-Chantar, Maria L, Dieguez, Carlos, Varela-Rey, Marta, Prevot, Vincent, Schwaninger, Markus, Meijnikman, Abraham, Bravo, Susana B, Frühbeck, Gema, Nogueiras, Ruben

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p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1 by Quiñones, Mar, Al-Massadi, Omar, Folgueira, Cintia, Bremser, Stephan, Gallego, Rosalía, Torres-Leal, Leonardo, Haddad-Tóvolli, Roberta, García-Caceres, Cristina, Hernandez-Bautista, Rene, Lam, Brian Y. H., Beiroa, Daniel, Sanchez-Rebordelo, Estrella, Senra, Ana, Malagon, Jose A., Valerio, Patricia, Fondevila, Marcos F., Fernø, Johan, Malagon, Maria M., Contreras, Raian, Pfluger, Paul, Brüning, Jens C., Yeo, Giles, Tschöp, Matthias, Diéguez, Carlos, López, Miguel, Claret, Marc, Kloppenburg, Peter, Sabio, Guadalupe, Nogueiras, Ruben

“…p53 is a well-known tumor suppressor that has emerged as an important player in energy balance. However, its metabolic role in the hypothalamus remains…”
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The lipopolysaccharide-TLR4 axis regulates hepatic glutaminase 1 expression promoting liver ammonia build-up as steatotic liver disease progresses to steatohepatitis by Mercado-Gómez, Maria, Goikoetxea-Usandizaga, Naroa, Kerbert, Annarein J.C., Gracianteparaluceta, Leire Uraga, Serrano-Maciá, Marina, Lachiondo-Ortega, Sofia, Rodriguez-Agudo, Rubén, Gil-Pitarch, Clàudia, Simón, Jorge, González-Recio, Irene, Fondevila, Marcos F., Santamarina-Ojeda, Pablo, Fraga, Mario F., Nogueiras, Rubén, Heras, Javier de las, Jalan, Rajiv, Martínez-Chantar, María Luz, Delgado, Teresa C.

“…Ammonia is a pathogenic factor implicated in the progression of metabolic-associated steatotic liver disease (MASLD). The contribution of the glutaminase 1…”
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Metabolic Landscape of the Mouse Liver by Quantitative 31P Nuclear Magnetic Resonance Analysis of the Phosphorome by Bernardo‐Seisdedos, Ganeko, Bilbao, Jon, Fernández‐Ramos, David, Lopitz‐Otsoa, Fernando, Gutierrez de Juan, Virginia, Bizkarguenaga, Maider, Mateos, Borja, Fondevila, Marcos F., Abril‐Fornaguera, Jordi, Diercks, Tammo, Lu, Shelly C., Nogueiras, Rubén, Mato, José M., Millet, Oscar

“…Background and Aims The liver plays a central role in all metabolic processes in the body. However, precise characterization of liver metabolism is often…”
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Hepatic p63 regulates steatosis via IKKβ/ER stress by Porteiro, Begoña, Fondevila, Marcos F., Delgado, Teresa C., Iglesias, Cristina, Imbernon, Monica, Iruzubieta, Paula, Crespo, Javier, Zabala-Letona, Amaia, Fernø, Johan, González-Terán, Bárbara, Matesanz, Nuria, Hernández-Cosido, Lourdes, Marcos, Miguel, Tovar, Sulay, Vidal, Anxo, Sánchez-Ceinos, Julia, Malagon, Maria M., Pombo, Celia, Zalvide, Juan, Carracedo, Arkaitz, Buque, Xabier, Dieguez, Carlos, Sabio, Guadalupe, López, Miguel, Aspichueta, Patricia, Martínez-Chantar, María L., Nogueiras, Ruben

“…p53 family members control several metabolic and cellular functions. The p53 ortholog p63 modulates cellular adaptations to stress and has a major role in cell…”
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Hypothalamic dopamine signalling regulates brown fat thermogenesis by Folgueira, Cintia, Beiroa, Daniel, Porteiro, Begoña, Duquenne, Manon, Puighermanal, Emma, Fondevila, Marcos F., Barja-Fernández, Silvia, Gallego, Rosalia, Hernández-Bautista, René, Castelao, Cecilia, Senra, Ana, Seoane-Collazo, Patricia, Gómez-Lado, Noemi, Aguiar, Pablo, Guallar, Diana, Fidalgo, Miguel, Romero-Pico, Amparo, Adan, Roger, Blouet, Clemence, Labandeira-García, Jose Luís, Jeanrenaud, Françoise, Kallo, Imre, Liposits, Zsolt, Salvador, Javier, Prevot, Vincent, Dieguez, Carlos, López, Miguel, Valjent, Emmanuel, Frühbeck, Gema, Seoane, Luisa M., Nogueiras, Ruben

“…Dopamine signalling is a crucial part of the brain reward system and can affect feeding behaviour. Dopamine receptors are also expressed in the hypothalamus,…”
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