Search Results - "Fominaya, J"

Cellular senescence bypass screen identifies new putative tumor suppressor genes by Leal, J F M, Fominaya, J, Cascón, A, Guijarro, M V, Blanco-Aparicio, C, Lleonart, M, Castro, M E, Ramon y Cajal, S, Robledo, M, Beach, D H, Carnero, A

“…Senescence is a mechanism that limits cellular lifespan and constitutes a barrier against cellular immortalization. To identify new senescence regulatory genes…”
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MAP17 enhances the malignant behavior of tumor cells through ROS increase by Guijarro, Maria V., Leal, Juan F.M., Blanco-Aparicio, Carmen, Alonso, Soledad, Fominaya, Jesús, Lleonart, Matilde, Castellvi, Josep, Ramon y Cajal, Santiago, Carnero, Amancio

“…Tumorigenesis occurs when the mechanisms involved in the control of tissue homeostasis are disrupted and cells stop responding to physiological signals…”
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A chimeric fusion protein containing transforming growth factor-α mediates gene transfer via binding to the EGF receptor by FOMINAYAL, J, UHEREK, C, WELS, W

“…Fusion proteins engineered to incorporate distinct functions which co-operate in mediating the cell-type specific uptake and intracellular delivery of DNA…”
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A shift-and-convolution technique for high-resolution radar images by Perez-Martinez, F., Garcia-Fominaya, J., Calvo-Gallego, J.

“…Theoretical and experimental results of a new method able to obtain images with high-resolution radars (HRRs) are presented in this paper. This algorithm does…”
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134 Biological characterization of ETP-46321 a potent and selective phosphoinositide-3-kinase inhibitor with antitumor activity by Bischoff, J.R, Pastor, J, Cebrián, D, Martínez, S, Lorenzo, M, Merino, T, Fominaya, J, Pizcueta, P, Lopez, A. Rodríguez, Granda, T.G

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177 Amino-carbonyl substituted fused imidazoles: potent, selective and orally bioavailable inhibitors of PI3K by Pastor, J, Martínez, S, Álvarez, R.M, Hernández, A.I, Varela, C, García, A.B, Rabal, O, González-Granda, M.T, Fominaya, J, Bischoff, J.R

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Inactivation of ribonuclease inhibitor by thiol-disulfide exchange by FOMINAYA, J. M, HOFSTEENGE, J

“…Porcine ribonuclease inhibitor (RI) contains 30 1/2-cystinyl residues, all of which occur in the reduced form. Reaction of the native protein with…”
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Oxidation of Sulfhydryl Groups of Ribonuclease Inhibitor in Epithelial Cells Is Sufficient for Its Intracellular Degradation by Blázquez, Montserrat, Fominaya, Jesús M., Hofsteenge, Jan

“…Ribonuclease inhibitor (RI) is a cytoplasmic protein (50 kDa) that inhibits a variety of pancreatic type RNases. The porcine inhibitor contains 30 cysteine…”
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Target cell-specific DNA transfer mediated by a chimeric multidomain protein. Novel non-viral gene delivery system by Fominaya, J, Wels, W

“…Based on the multidomain structure of the bacterial Pseudomonas exotoxin A, a recombinant fusion protein was constructed which serves as a target cell-specific…”
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Theoretical treatment of tight-binding inhibition of an enzyme. Ribonuclease inhibitor as special case by Fominaya, J M, García-Segura, J M, Ferreras, M, Gavilanes, J G

“…A general treatment of very tight-binding inhibition is described. It was applied to purified endogenous RNAase inhibitor from rat testis. This treatment…”
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A Modular DNA Carrier Protein Based on the Structure of Diphtheria Toxin Mediates Target Cell-specific Gene Delivery by Uherek, Christoph, Fominaya, Jesús, Wels, Winfried

“…Modular fusion proteins that combine distinct functions required for cell type-specific uptake and intracellular delivery of DNA present an attractive approach…”
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Effect of different baculovirus inactivation procedures on the integrity and immunogenicity of porcine parvovirus-like particles by Rueda, Paloma, Fominaya, Jesús, Langeveld, Jan P.M, Bruschke, Christianne, Vela, C, Casal, J.Ignacio

“…We have demonstrated earlier the usefulness of recombinant porcine parvovirus (PPV) virus-like particles (VLPs) as an efficient recombinant vaccine for PPV…”
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Inhibition of phosphatidylinositol-3-kinase synergizes with gemcitabine in low-passage tumor cell lines correlating with Bax translocation to the mitochondria by Blanco-Aparicio, Carmen, Pequeño, Belen, Moneo, Victoria, Romero, Lourdes, Leal, Juan F. M, Velasco, Juan, Fominaya, Jesús, Carnero, Amancio

“…Apoptotic pathways, including the phosphatidylinositol-3-kinase (PI3K)/AKT survival pathway, are altered in most cancer cells in relation to their normal…”
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Purification, molecular and enzymic characterization of an acid RNase from the insect Ceratitis capitata by Garcia-Segura, J.M, Orozco, M.M, Fominaya, J.M, Gavilanes, J.G

“…An acid ribonuclease has been purified from the insect Ceratitis capitata. The specific activity of the purified enzyme is 580 units/mg. This enzyme is a…”
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Identification of an immunodominant epitope in the C terminus of glycoprotein 5 of porcine reproductive and respiratory syndrome virus by Rodriguez, Maria Jose, Sarraseca, Javier, Fominaya, Jesus, Cortes, Elena, Sanz, Antonio, Casal, J. Ignacio

“…INGENASA, Hermanos Garcia Noblejas 41, 28037 Madrid, Spain 1 Author for correspondence: J. Ignacio Casal. Fax +34 91 4087598. e-mail icasal{at}ingenasa.es…”
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An optimized amphiphilic cationic peptide as an efficient non-viral gene delivery vector by Fominaya, Jesús, Gasset, María, García, Rosana, Roncal, Fernando, Pablo Albar, Juan, Bernad, Antonio

“…Background Due to their chemical definition and reduced size, the use of peptides as gene delivery systems is gaining interest as compared to the more common…”
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On the degradation of intracellular RNA by ribonucleases by García-Segura, J M, Fominaya, J M, Orozco, M M, Gavilanes, J G

“…The kinetic and the specificity of two RNases purified from the insect. C. capitata have been studied. These two enzymes exhibit preference to degrade large…”
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Residues 287-301 of human ribonuclease inhibitor do not affect ribonuclease activity and inhibitor binding; a reply by Fominaya, J, Neumann, U, Hofsteenge, J

“…Residues 287-301 of human placental ribonuclease inhibitor have been reported to inhibit pancreatic ribonuclease A in a similar way as the entire inhibitor…”
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Ribonuclease-RNAase inhibitor complex from rat testis. Purification of the RNAase inhibitor by Fominaya, J M, García-Segura, J M, Gavilanes, J G

“…The RNAase inhibitor from rat testis has been purified to homogeneity. The purified protein appeared as a single spot after two-dimensional electrophoresis…”
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Experimental results on marine targets classification with surveillance HRR by means of non coherent techniques based on hot spots accurate location by Martinez, F.P., Fominaya, J.G., Gallego, J.C.

“…In this article, the experimental results are presented of applying a new non coherent and non statistic technique that allows us to endow the coastal…”
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