Search Results - "Follows, George A"

Phosphatidylinositol 3-Kinase Inhibition by Copanlisib in Relapsed or Refractory Indolent Lymphoma by Dreyling, Martin, Santoro, Armando, Mollica, Luigina, Leppä, Sirpa, Follows, George A, Lenz, Georg, Kim, Won Seog, Nagler, Arnon, Panayiotidis, Panayiotis, Demeter, Judit, Özcan, Muhit, Kosinova, Marina, Bouabdallah, Krimo, Morschhauser, Franck, Stevens, Don A, Trevarthen, David, Giurescu, Marius, Cupit, Lisa, Liu, Li, Köchert, Karl, Seidel, Henrik, Peña, Carol, Yin, Shuxin, Hiemeyer, Florian, Garcia-Vargas, Jose, Childs, Barrett H, Zinzani, Pier Luigi

“…Purpose Phosphatidylinositol 3-kinase (PI3K) signaling is critical for the proliferation and survival of malignant B cells. Copanlisib, a pan-class I PI3K…”
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Network properties derived from deep sequencing of human B-cell receptor repertoires delineate B-cell populations by Bashford-Rogers, Rachael J M, Palser, Anne L, Huntly, Brian J, Rance, Richard, Vassiliou, George S, Follows, George A, Kellam, Paul

“…The adaptive immune response selectively expands B- and T-cell clones following antigen recognition by B- and T-cell receptors (BCR and TCR), respectively…”
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Subclonal phylogenetic structures in cancer revealed by ultra-deep sequencing by Campbell, Peter J, Pleasance, Erin D, Stephens, Philip J, Dicks, Ed, Rance, Richard, Goodhead, Ian, Follows, George A, Green, Anthony R, Futreal, P. Andy, Stratton, Michael R

“…During the clonal expansion of cancer from an ancestral cell with an initiating oncogenic mutation to symptomatic neoplasm, the occurrence of somatic mutations…”
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Alemtuzumab in Combination With Methylprednisolone Is a Highly Effective Induction Regimen for Patients With Chronic Lymphocytic Leukemia and Deletion of TP53: Final Results of the National Cancer Research Institute CLL206 Trial by PETTITT, Andrew R, JACKSON, Richard, CATOVSKY, Daniel, RADFORD, John A, BLOOR, Adrian, FOLLOWS, George A, DEVEREUX, Stephen, KRUGER, Anton, BLUNDELL, Julie, AGRAWAL, Samir, ALLSUP, David, PROCTOR, Stephen, CARRUTHERS, Stacey, HEARTIN, Earnest, OSCIER, David, HAMBLIN, Terry J, RAWSTRON, Andrew, HILLMEN, Peter, DODD, James, DODD, Susanna, OATES, Melanie, JOHNSON, Gillian G, SCHUH, Anna, MATUTES, Estella, DEARDEN, Claire E

“…In chronic lymphocytic leukemia (CLL), TP53 deletion/mutation is strongly associated with an adverse outcome and resistance to chemotherapy-based treatment. In…”
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Early detection of T-cell lymphoma with T follicular helper phenotype by RHOA mutation analysis by Dobson, Rachel, Du, Peter Y, Rásó-Barnett, Lívia, Yao, Wen-Qing, Chen, Zi, Casa, Calogero, Ei-Daly, Hesham, Farkas, Lorant, Soilleux, Elizabeth, Wright, Penny, Grant, John W, Rodriguez-Justo, Manuel, Follows, George A, Rashed, Hala, Fabre, Margarete, Baxter, E Joanna, Vassiliou, George, Wotherspoon, Andrew, Attygalle, Ayoma D, Liu, Hongxiang, Du, Ming-Qing

“…Angioimmunoblastic T-cell lymphoma (AITL) and peripheral T-cell lymphoma with T follicular helper phenotype (PTCL-TFH) are a group of complex…”
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Guidelines for the first line management of classical Hodgkin lymphoma by Follows, George A., Ardeshna, Kirit M., Barrington, Sally F., Culligan, Dominic J., Hoskin, Peter J., Linch, David, Sadullah, Shalal, Williams, Michael V., Wimperis, Jennifer Z.

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Relapsed mantle cell lymphoma presenting with lactic acidosis and hypoglycemia: A case report by Carson, Lucy, Johnston, Andrew, Follows, George A., Santarsieri, Anna

“…Lactic acidosis and hypoglycemia are rare presentations of malignancy with a poor prognosis. We present the case of a mantle cell lymphoma patient who relapsed…”
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Managing relapsed refractory lymphoma with palliative oral chemotherapy: A multicentre retrospective study by Bulley, Simon J., Santarsieri, Anna, Lentell, Isabel C., O'Sullivan, Brendan, Hodson, Andrew, Firth, Oliver, Sadullah, Shalal, Follows, Annabel M., Karanth, Mamatha, Min, Sandra Young, Fowler, Alexis, Russell, James, Uttenthal, Benjamin J., Hodson, Daniel J., Follows, George A.

“…PEP‐C (prednisolone, etoposide, procarbazine and cyclophosphamide) is an orally administered daily chemotherapy regimen used with palliative intent in relapsed…”
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Mapping long-range promoter contacts in human cells with high-resolution capture Hi-C by Mifsud, Borbala, Tavares-Cadete, Filipe, Young, Alice N, Sugar, Robert, Schoenfelder, Stefan, Ferreira, Lauren, Wingett, Steven W, Andrews, Simon, Grey, William, Ewels, Philip A, Herman, Bram, Happe, Scott, Higgs, Andy, LeProust, Emily, Follows, George A, Fraser, Peter, Luscombe, Nicholas M, Osborne, Cameron S

“…Nicholas Luscombe, Cameron Osborne and colleagues report the use of Capture Hi-C (CHi-C) to detect the long-range interactions of almost 22,000 promoters in 2…”
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Transverse Leukonychia (Mees’ Lines) by Follows, Annabel M., Follows, George A.

“…Transverse Leukonychia (Mees’ Lines)A 30-year-old man presented with a 4-month history of white lines across his fingernails. The nail changes had first…”
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The prognosis of MYC translocation positive diffuse large B‐cell lymphoma depends on the second hit by Clipson, Alexandra, Barrans, Sharon, Zeng, Naiyan, Crouch, Simon, Grigoropoulos, Nicholas F, Liu, Hongxiang, Kocialkowski, Sylvia, Wang, Ming, Huang, Yuanxue, Worrillow, Lisa, Goodlad, John, Buxton, Jenny, Neat, Michael, Fields, Paul, Wilkins, Bridget, Grant, John W, Wright, Penny, EI‐Daly, Hesham, Follows, George A, Roman, Eve, Watkins, A James, Johnson, Peter W M, Jack, Andrew, Du, Ming‐Qing

“…A proportion of MYC translocation positive diffuse large B‐cell lymphomas (DLBCL) harbour a BCL2 and/or BCL6 translocation, known as double‐hit DLBCL, and are…”
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DNA damage-induced Bcl-xL deamidation is mediated by NHE-1 antiport regulated intracellular pH by Zhao, Rui, Oxley, David, Smith, Trevor S, Follows, George A, Green, Anthony R, Alexander, Denis R

“…The pro-survival protein Bcl-xL is critical for the resistance of tumour cells to DNA damage. We have previously demonstrated, using a mouse cancer model, that…”
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Fixed-duration ibrutinib–venetoclax versus chlorambucil–obinutuzumab in previously untreated chronic lymphocytic leukaemia (GLOW): 4-year follow-up from a multicentre, open-label, randomised, phase 3 trial by Niemann, Carsten U, Munir, Talha, Moreno, Carol, Owen, Carolyn, Follows, George A, Benjamini, Ohad, Janssens, Ann, Levin, Mark-David, Robak, Tadeusz, Simkovic, Martin, Voloshin, Sergey, Vorobyev, Vladimir, Yagci, Munci, Ysebaert, Loic, Qi, Keqin, Qi, Qianya, Sinet, Pierre, Parisi, Lori, Srinivasan, Srimathi, Schuier, Natasha, Baeten, Kurt, Howes, Angela, Caces, Donne Bennett, Kater, Arnon P

“…In the GLOW study, fixed-duration ibrutinib–venetoclax showed superior progression-free survival versus chlorambucil–obinutuzumab in patients with previously…”
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Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development by Stephens, Philip J., Greenman, Chris D., Fu, Beiyuan, Yang, Fengtang, Bignell, Graham R., Mudie, Laura J., Pleasance, Erin D., Lau, King Wai, Beare, David, Stebbings, Lucy A., McLaren, Stuart, Lin, Meng-Lay, McBride, David J., Varela, Ignacio, Nik-Zainal, Serena, Leroy, Catherine, Jia, Mingming, Menzies, Andrew, Butler, Adam P., Teague, Jon W., Quail, Michael A., Burton, John, Swerdlow, Harold, Carter, Nigel P., Morsberger, Laura A., Iacobuzio-Donahue, Christine, Follows, George A., Green, Anthony R., Flanagan, Adrienne M., Stratton, Michael R., Futreal, P. Andrew, Campbell, Peter J.

“…Cancer is driven by somatically acquired point mutations and chromosomal rearrangements, conventionally thought to accumulate gradually over time. Using…”
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cis-Regulatory Remodeling of the SCL Locus during Vertebrate Evolution by Göttgens, Berthold, Ferreira, Rita, Sanchez, Maria-José, Ishibashi, Shoko, Li, Juan, Spensberger, Dominik, Lefevre, Pascal, Ottersbach, Katrin, Chapman, Michael, Kinston, Sarah, Knezevic, Kathy, Hoogenkamp, Maarten, Follows, George A, Bonifer, Constanze, Amaya, Enrique, Green, Anthony R

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Copanlisib for the Treatment of Malignant Lymphoma: Clinical Experience and Future Perspectives by Munoz, Javier, Follows, George A., Nastoupil, Loretta J.

“…Dysregulation of phosphatidylinositol 3-kinase (PI3K)/protein kinase B/mammalian target of rapamycin signaling is common in both indolent and aggressive forms…”
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Assessment of fitness for bleomycin use and management of bleomycin pulmonary toxicity in patients with classical Hodgkin lymphoma: A British Society for Haematology Good Practice Paper by Barrett, Aisling, Shah, Nimish, Chadwick, Andrew, Burns, David, Burton, Cathy, Cutter, David J., Follows, George A., McKay, Pam, Osborne, Wendy, Phillips, Elizabeth, Wilson, Matthew R., Collins, Graham P.

“…Summary This good practice paper (GPP) is intended to support clinicians in assessing patient fitness for bleomycin and in management of bleomycin pulmonary…”
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Mapping and functional characterisation of a CTCF-dependent insulator element at the 3' border of the murine Scl transcriptional domain by Follows, George A, Ferreira, Rita, Janes, Mary E, Spensberger, Dominik, Cambuli, Francesco, Chaney, Amy F, Kinston, Sarah J, Landry, Josette R, Green, Anthony R, Göttgens, Berthold

“…The Scl gene encodes a transcription factor essential for haematopoietic development. Scl transcription is regulated by a panel of cis-elements spread over 55…”
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Germ line mutations in shelterin complex genes are associated with familial chronic lymphocytic leukemia by Speedy, Helen E., Kinnersley, Ben, Chubb, Daniel, Broderick, Peter, Law, Philip J., Litchfield, Kevin, Jayne, Sandrine, Dyer, Martin J.S., Dearden, Claire, Follows, George A., Catovsky, Daniel, Houlston, Richard S.

“…Chronic lymphocytic leukemia (CLL) can be familial; however, thus far no rare germ line disruptive alleles for CLL have been identified. We performed…”
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Incidence and outcomes of post‐transplant lymphoproliferative disease after 5365 solid‐organ transplants over a 20‐year period at two UK transplant centres by Santarsieri, Anna, Rudge, John F., Amin, Irum, Gelson, Will, Parmar, Jasvir, Pettit, Stephen, Sharkey, Lisa, Uttenthal, Benjamin J., Follows, George A.

“…Summary Post‐transplant lymphoproliferative disease (PTLD) is a life‐threatening complication of solid‐organ transplantation (SOT). We present the incidence…”
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