Search Results - "Folkes, Lisa K."

The anti-malarial atovaquone increases radiosensitivity by alleviating tumour hypoxia by Ashton, Thomas M., Fokas, Emmanouil, Kunz-Schughart, Leoni A., Folkes, Lisa K., Anbalagan, Selvakumar, Huether, Melanie, Kelly, Catherine J., Pirovano, Giacomo, Buffa, Francesca M., Hammond, Ester M., Stratford, Michael, Muschel, Ruth J., Higgins, Geoff S., McKenna, William Gillies

“…Tumour hypoxia renders cancer cells resistant to cancer therapy, resulting in markedly worse clinical outcomes. To find clinical candidate compounds that…”
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Radiolysis Studies of Oxidation and Nitration of Tyrosine and Some Other Biological Targets by Peroxynitrite-Derived Radicals by Folkes, Lisa K, Bartesaghi, Silvina, Trujillo, Madia, Wardman, Peter, Radi, Rafael

“…The widespread interest in free radicals in biology extends far beyond the effects of ionizing radiation, with recent attention largely focusing on reactions…”
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Development and pre-clinical testing of a novel hypoxia-activated KDAC inhibitor by Skwarska, Anna, Calder, Ewen D D, Sneddon, Deborah, Bolland, Hannah, Odyniec, Maria L, Mistry, Ishna N, Martin, Jennifer, Folkes, Lisa K, Conway, Stuart J, Hammond, Ester M

“…Tumor hypoxia is associated with therapy resistance and poor patient prognosis. Hypoxia-activated prodrugs, designed to selectively target hypoxic cells while…”
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Effects of Acute versus Chronic Hypoxia on DNA Damage Responses and Genomic Instability by PIRES, Isabel M, BENCOKOVA, Zuzana, MILANI, Manuela, FOLKES, Lisa K, LI, Ji-Liang, STRATFORD, Mike R, HARRIS, Adrian L, HAMMOND, Ester M

“…Questions exist concerning the effects of acute versus chronic hypoxic conditions on DNA replication and genomic stability that may influence tumorigenesis…”
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Kinetics of reduction of tyrosine phenoxyl radicals by glutathione by Folkes, Lisa K., Trujillo, Madia, Bartesaghi, Silvina, Radi, Rafael, Wardman, Peter

“…► Glutathione reduces tyrosyl radicals ∼220 × slower than ascorbate at pH 7. ► Reduction potential of the tyrosyl radical is similar to glutathione radical. ►…”
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Phase I Clinical Trial of Weekly Combretastatin A4 Phosphate: Clinical and Pharmacokinetic Results by RUSTIN, Gordon J. S, GALBRAITH, Susan M, ANDERSON, Helen, STRATFORD, Michael, FOLKES, Lisa K, SENA, Luiza, GUMBRELL, Lindsey, PRICE, Patricia M

“…A phase I trial was performed with combretastatin A4 phosphate (CA4P), a novel tubulin-binding agent that has been shown to rapidly reduce blood flow in animal…”
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CYP450 Enzymes Effect Oxygen-Dependent Reduction of Azide-Based Fluorogenic Dyes by O’Connor, Liam J, Mistry, Ishna N, Collins, Sarah L, Folkes, Lisa K, Brown, Graham, Conway, Stuart J, Hammond, Ester M

“…Azide-containing compounds have broad utility in organic synthesis and chemical biology. Their use as powerful tools for the labeling of biological systems in…”
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Identification of vitamin B1 metabolism as a tumor-specific radiosensitizing pathway using a high-throughput colony formation screen by Tiwana, Gaganpreet S, Prevo, Remko, Buffa, Francesca M, Yu, Sheng, Ebner, Daniel V, Howarth, Alison, Folkes, Lisa K, Budwal, Balam, Chu, Kwun-Ye, Durrant, Lisa, Muschel, Ruth J, McKenna, W Gillies, Higgins, Geoff S

“…Colony formation is the gold standard assay for determining reproductive cell death after radiation treatment, since effects on proliferation often do not…”
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Effect of nitric-oxide synthesis on tumour blood volume and vascular activity: a phase I study by Ng, Quan-Sing, MRCP, Goh, Vicky, FRCR, Milner, Jessica, BSc, Stratford, Michael R, PhD, Folkes, Lisa K, BSc, Tozer, Gillian M, Prof, Saunders, Michele I, Prof, Hoskin, Peter J, Prof

“…Summary Background Nitric oxide has been implicated in tumour angiogenesis and in the maintaining of vasodilator tone of tumour blood vessels. The tumour…”
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Radiosensitization by Nitric Oxide at Low Radiation Doses by Wardman, Peter, Rothkamm, Kai, Folkes, Lisa K., Woodcock, Michael, Johnston, Peter J.

“…Wardman, P., Rothkamm, K., Folkes, L. K., Woodcock, M. and Johnston, P. J. Radiosensitization by Nitric Oxide at Low Radiation Doses. Radiat. Res. 167, 475–484…”
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Safety and feasibility of ultrasound-triggered targeted drug delivery of doxorubicin from thermosensitive liposomes in liver tumours (TARDOX): a single-centre, open-label, phase 1 trial by Lyon, Paul C, Gray, Michael D, Mannaris, Christophoros, Folkes, Lisa K, Stratford, Michael, Campo, Leticia, Chung, Daniel Y F, Scott, Shaun, Anderson, Mark, Goldin, Robert, Carlisle, Robert, Wu, Feng, Middleton, Mark R, Gleeson, Fergus V, Coussios, Constantin C

“…Previous preclinical research has shown that extracorporeal devices can be used to enhance the delivery and distribution of systemically administered…”
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Focused Ultrasound Hyperthermia for Targeted Drug Release from Thermosensitive Liposomes: Results from a Phase I Trial by Gray, Michael D, Lyon, Paul C, Mannaris, Christophoros, Folkes, Lisa K, Stratford, Michael, Campo, Leticia, Chung, Daniel Y F, Scott, Shaun, Anderson, Mark, Goldin, Robert, Carlisle, Robert, Wu, Feng, Middleton, Mark R, Gleeson, Fergus V, Coussios, Constantin C

“…Purpose To demonstrate the feasibility and safety of using focused ultrasound planning models to determine the treatment parameters needed to deliver…”
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The effects of nitric oxide or oxygen on the stable products formed from the tyrosine phenoxyl radical by Folkes, Lisa K, Bartesaghi, Silvina, Trujillo, Madia, Wardman, Peter, Radi, Rafael

“…Tyrosine is a critical component of many proteins and can be the subject of oxidative posttranslational modifications. Furthermore, the oxidation of tyrosine…”
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Modification of DNA damage mechanisms by nitric oxide during ionizing radiation by Folkes, Lisa K., O'Neill, Peter

“…Nitric oxide (•NO) is a very effective radiosensitizer of hypoxic mammalian cells. In vivo •NO may have effects on tumor vasculature and hence on tumor…”
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Mitochondrial Inhibitor Atovaquone Increases Tumor Oxygenation and Inhibits Hypoxic Gene Expression in Patients with Non-Small Cell Lung Cancer by Skwarski, Michael, McGowan, Daniel R, Belcher, Elizabeth, Di Chiara, Francesco, Stavroulias, Dionisios, McCole, Mark, Derham, Jennifer L, Chu, Kwun-Ye, Teoh, Eugene, Chauhan, Jagat, O'Reilly, Dawn, Harris, Benjamin H L, Macklin, Philip S, Bull, Joshua A, Green, Marcus, Rodriguez-Berriguete, Gonzalo, Prevo, Remko, Folkes, Lisa K, Campo, Leticia, Ferencz, Petra, Croal, Paula L, Flight, Helen, Qi, Cathy, Holmes, Jane, O'Connor, James P B, Gleeson, Fergus V, McKenna, W Gillies, Harris, Adrian L, Bulte, Daniel, Buffa, Francesca M, Macpherson, Ruth E, Higgins, Geoff S

“…Tumor hypoxia fuels an aggressive tumor phenotype and confers resistance to anticancer treatments. We conducted a clinical trial to determine whether the…”
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Reactivity of hydrogen sulfide with peroxynitrite and other oxidants of biological interest by Carballal, Sebastián, Trujillo, Madia, Cuevasanta, Ernesto, Bartesaghi, Silvina, Möller, Matías N., Folkes, Lisa K., García-Bereguiaín, Miguel A., Gutiérrez-Merino, Carlos, Wardman, Peter, Denicola, Ana, Radi, Rafael, Alvarez, Beatriz

“…Hydrogen sulfide (H 2S) is an endogenously generated gas that can also be administered exogenously. It modulates physiological functions and has reported…”
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Probing the limits of Q-tag bioconjugation of antibodies by Marculescu, Cristina, Lakshminarayanan, Abirami, Gault, Joseph, Knight, James C, Folkes, Lisa K, Spink, Thomas, Robinson, Carol V, Vallis, Katherine, Davis, Benjamin G, Cornelissen, Bart

“…Site-selective labelling of antibodies (Abs) can circumvent problems from heterogeneity of conventional conjugation. Here, we evaluate the industrially-applied…”
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DNA damage induced by nitric oxide during ionizing radiation is enhanced at replication by Folkes, Lisa K., O’Neill, Peter

“…•Nitric oxide reacts with hydroxyl radical-induced adenine radicals to form hypoxanthine and 8-azaadenine.•Radiosensitization of cells by nitric oxide…”
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Results of a phase II clinical trial of 6-mercaptopurine (6MP) and methotrexate in patients with BRCA-defective tumours by Roberts, Corran, Strauss, Victoria Y., Kopijasz, Sylwia, Gourley, Charlie, Hall, Marcia, Montes, Ana, Abraham, Jacinta, Clamp, Andrew, Kennedy, Richard, Banerjee, Susana, Folkes, Lisa K., Stratford, Michael, Nicum, Shibani

“…Background Tumour cells with BRCA1/2 gene mutations demonstrate increased sensitivity to platinum and poly (ADP-ribose) polymerase (PARP) inhibitors…”
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Targeting IGF Perturbs Global Replication through Ribonucleotide Reductase Dysfunction by Rieunier, Guillaume, Wu, Xiaoning, Harris, Letitia E, Mills, Jack V, Nandakumar, Ashwin, Colling, Laura, Seraia, Elena, Hatch, Stephanie B, Ebner, Daniel V, Folkes, Lisa K, Weyer-Czernilofsky, Ulrike, Bogenrieder, Thomas, Ryan, Anderson J, Macaulay, Valentine M

“…Inhibition of IGF receptor (IGF1R) delays repair of radiation-induced DNA double-strand breaks (DSB), prompting us to investigate whether IGF1R influences…”
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