Search Results - "Folkert Reck"

Challenges of antibacterial drug discovery by Reck, Folkert, Jansen, Johanna M., Moser, Heinz E.

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A Unified Framework for the Incorporation of Bioorthogonal Compound Exposure Probes within Biological Compartments by Spangler, Benjamin, Yang, Shengtian, Baxter Rath, Christopher M, Reck, Folkert, Feng, Brian Y

“…Compartmentalization is a crucial facet of many biological systems, and key aspects of cellular processes rely on spatial segregation within the cell. While…”
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Identification of Mutations in the mrdA Gene Encoding PBP2 That Reduce Carbapenem and Diazabicyclooctane Susceptibility of Escherichia coli Clinical Isolates with Mutations in ftsI (PBP3) and Which Carry blaNDM-1 by Srijan, Ranjitkar, Reck Folkert, Ke Xiaobo, Zhu Qingming, McEnroe, Glenn, Lopez, Sara L, Dean, Charles R

“…ABSTRACTPenicillin-binding proteins (PBPs) are essential for bacterial cell wall biosynthesis, and several are clinically validated antibacterial targets of…”
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Inhibitors of the bacterial cell wall biosynthesis enzyme MurC by Reck, Folkert, Marmor, Stephen, Fisher, Stewart, Wuonola, Mark A.

“…A series of phosphinate transition-state analogues of the l-alanine adding enzyme (MurC) of bacterial peptidoglycan biosynthesis was prepared and tested as…”
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Scale-Up Synthesis of IID572: A New β‑Lactamase Inhibitor by Furegati, Markus, Nocito, Sandro, Reck, Folkert, Casarez, Anthony, Simmons, Robert, Schuetz, Heiner, Koch, Guido

“…The new potentially best-in-class β-lactamase inhibitor IID572 was discovered by a late-stage functionalization approach. An alternative synthesis was…”
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In Vitro Activity of LYS228, a Novel Monobactam Antibiotic, against Multidrug-Resistant Enterobacteriaceae by Blais, Johanne, Lopez, Sara, Li, Cindy, Ruzin, Alexey, Ranjitkar, Srijan, Dean, Charles R, Leeds, Jennifer A, Casarez, Anthony, Simmons, Robert L, Reck, Folkert

“…LYS228 is a novel monobactam with potent activity against LYS228 is stable to metallo-β-lactamases (MBLs) and serine carbapenemases, including carbapenemases…”
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Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae – Identification of LYS228 by Reck, Folkert, Bermingham, Alun, Blais, Johanne, Capka, Vladimir, Cariaga, Taryn, Casarez, Anthony, Colvin, Richard, Dean, Charles R., Fekete, Alex, Gong, Wanben, Growcott, Ellie, Guo, Hongqiu, Jones, Adriana K., Li, Cindy, Li, Fengxia, Lin, Xiaodong, Lindvall, Mika, Lopez, Sara, McKenney, David, Metzger, Louis, Moser, Heinz E., Prathapam, Ramadevi, Rasper, Dita, Rudewicz, Patrick, Sethuraman, Vijay, Shen, Xiaoyu, Shaul, Jacob, Simmons, Robert L., Tashiro, Kyuto, Tang, Dazhi, Tjandra, Meiliana, Turner, Nancy, Uehara, Tsuyoshi, Vitt, Charles, Whitebread, Steven, Yifru, Aregahegn, Zang, Xu, Zhu, Qingming

“…[Display omitted] Metallo-β-lactamases (MBLs), such as New Delhi metallo-β-lactamase (NDM-1) have spread world-wide and present a serious threat. Expression of…”
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Mode of Action of the Monobactam LYS228 and Mechanisms Decreasing In Vitro Susceptibility in Escherichia coli and Klebsiella pneumoniae by Dean, Charles R, Barkan, David T, Bermingham, Alun, Blais, Johanne, Casey, Fergal, Casarez, Anthony, Colvin, Richard, Fuller, John, Jones, Adriana K, Li, Cindy, Lopez, Sara, Metzger, 4th, Louis E, Mostafavi, Mina, Prathapam, Ramadevi, Rasper, Dita, Reck, Folkert, Ruzin, Alexey, Shaul, Jacob, Shen, Xiaoyu, Simmons, Robert L, Skewes-Cox, Peter, Takeoka, Kenneth T, Tamrakar, Pramila, Uehara, Tsuyoshi, Wei, Jun-Rong

“…The monobactam scaffold is attractive for the development of new agents to treat infections caused by drug-resistant Gram-negative bacteria because it is…”
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Novel N-Linked Aminopiperidine Inhibitors of Bacterial Topoisomerase Type II with Reduced p K a : Antibacterial Agents with an Improved Safety Profile by Reck, Folkert, Alm, Richard A., Brassil, Patrick, Newman, Joseph V., Ciaccio, Paul, McNulty, John, Barthlow, Herbert, Goteti, Kosalaram, Breen, John, Comita-Prevoir, Janelle, Cronin, Mark, Ehmann, David E., Geng, Bolin, Godfrey, Andrew Aydon, Fisher, Stewart L.

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Novel N-Linked Aminopiperidine Inhibitors of Bacterial Topoisomerase Type II: Broad-Spectrum Antibacterial Agents with Reduced hERG Activity by Reck, Folkert, Alm, Richard, Brassil, Patrick, Newman, Joseph, DeJonge, Boudewijn, Eyermann, Charles J, Breault, Gloria, Breen, John, Comita-Prevoir, Janelle, Cronin, Mark, Davis, Hajnalka, Ehmann, David, Galullo, Vincent, Geng, Bolin, Grebe, Tyler, Morningstar, Marshall, Walker, Phil, Hayter, Barry, Fisher, Stewart

“…Novel non-fluoroquinolone inhibitors of bacterial type II topoisomerases (DNA gyrase and topoisomerase IV) are of interest for the development of new…”
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NBTI 5463 Is a Novel Bacterial Type II Topoisomerase Inhibitor with Activity against Gram-Negative Bacteria and In Vivo Efficacy by DOUGHERTY, Thomas J, NAYAR, Asha, NEWMAN, Joseph V, HOPKINS, Sussie, STONE, Gregory G, JOHNSTONE, Michele, SHAPIRO, Adam B, CRONIN, Mark, RECK, Folkert, EHMANN, David E

“…The need for new antibiotics that address serious Gram-negative infections is well recognized. Our efforts with a series of novel bacterial type II…”
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Topoisomerase Inhibitors Addressing Fluoroquinolone Resistance in Gram-Negative Bacteria by Skepper, Colin K, Armstrong, Duncan, Balibar, Carl J, Bauer, Daniel, Bellamacina, Cornelia, Benton, Bret M, Bussiere, Dirksen, De Pascale, Gianfranco, De Vicente, Javier, Dean, Charles R, Dhumale, Bhavesh, Fisher, L. Mark, Fuller, John, Fulsunder, Mangesh, Holder, Lauren M, Hu, Cheng, Kantariya, Bhavin, Lapointe, Guillaume, Leeds, Jennifer A, Li, Xiaolin, Lu, Peichao, Lvov, Anatoli, Ma, Sylvia, Madhavan, Shravanthi, Malekar, Swapnil, McKenney, David, Mergo, Wosenu, Metzger, Louis, Moser, Heinz E, Mutnick, Daniel, Noeske, Jonas, Osborne, Colin, Patel, Ashish, Patel, Darshit, Patel, Tushar, Prajapati, Krunal, Prosen, Katherine R, Reck, Folkert, Richie, Daryl L, Rico, Alice, Sanderson, Mark R, Satasia, Shailesh, Sawyer, William S, Selvarajah, Jogitha, Shah, Nirav, Shanghavi, Kartik, Shu, Wei, Thompson, Katherine V, Traebert, Martin, Vala, Anand, Vala, Lakhan, Veselkov, Dennis A, Vo, Jason, Wang, Michael, Widya, Marcella, Williams, Sarah L, Xu, Yongjin, Yue, Qin, Zang, Richard, Zhou, Bo, Rivkin, Alexey

“…Since their discovery over 5 decades ago, quinolone antibiotics have found enormous success as broad spectrum agents that exert their activity through dual…”
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Novel N-Linked Aminopiperidine Inhibitors of Bacterial Topoisomerase Type II with Reduced pK a: Antibacterial Agents with an Improved Safety Profile by Reck, Folkert, Alm, Richard A, Brassil, Patrick, Newman, Joseph V, Ciaccio, Paul, McNulty, John, Barthlow, Herbert, Goteti, Kosalaram, Breen, John, Comita-Prevoir, Janelle, Cronin, Mark, Ehmann, David E, Geng, Bolin, Godfrey, Andrew Aydon, Fisher, Stewart L

“…Novel non-fluoroquinolone inhibitors of bacterial type II topoisomerases (DNA gyrase and topoisomerase IV) are of interest for the development of new…”
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Impact of Inducible bla DHA-1 on Susceptibility of Klebsiella pneumoniae Clinical Isolates to LYS228 and Identification of Chromosomal mpl and ampD Mutations Mediating Upregulation of Plasmid-Borne bla DHA-1 Expression by Jones, Adriana K, Ranjitkar, Srijan, Lopez, Sara, Li, Cindy, Blais, Johanne, Reck, Folkert, Dean, Charles R

“…Twenty-three ( ) clinical isolates exhibited a range of susceptibilities to LYS228, with MICs of ≥8 μg/ml for 9 of these. Mutants with decreased susceptibility…”
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Impact of Inducible blaDHA-1 on Susceptibility of Klebsiella pneumoniae Clinical Isolates to LYS228 and Identification of Chromosomal mpl and ampD Mutations Mediating Upregulation of Plasmid-Borne blaDHA-1 Expression by Jones, Adriana K, Ranjitkar, Srijan, Lopez, Sara, Li, Cindy, Blais, Johanne, Reck, Folkert, Dean, Charles R

“…Twenty-three Klebsiella pneumoniae (blaDHA-1) clinical isolates exhibited a range of susceptibilities to LYS228, with MICs of ≥8 μg/ml for 9 of these. Mutants…”
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Discovery and Optimization of DNA Gyrase and Topoisomerase IV Inhibitors with Potent Activity against Fluoroquinolone-Resistant Gram-Positive Bacteria by Lapointe, Guillaume, Skepper, Colin K, Holder, Lauren M, Armstrong, Duncan, Bellamacina, Cornelia, Blais, Johanne, Bussiere, Dirksen, Bian, Jianwei, Cepura, Cody, Chan, Helen, Dean, Charles R, De Pascale, Gianfranco, Dhumale, Bhavesh, Fisher, L. Mark, Fulsunder, Mangesh, Kantariya, Bhavin, Kim, Julie, King, Sean, Kossy, Lauren, Kulkarni, Upendra, Lakshman, Jay, Leeds, Jennifer A, Ling, Xiaolan, Lvov, Anatoli, Ma, Sylvia, Malekar, Swapnil, McKenney, David, Mergo, Wosenu, Metzger, Louis, Mhaske, Keshav, Moser, Heinz E, Mostafavi, Mina, Namballa, Sunil, Noeske, Jonas, Osborne, Colin, Patel, Ashish, Patel, Darshit, Patel, Tushar, Piechon, Philippe, Polyakov, Valery, Prajapati, Krunal, Prosen, Katherine R, Reck, Folkert, Richie, Daryl L, Sanderson, Mark R, Satasia, Shailesh, Savani, Bhautik, Selvarajah, Jogitha, Sethuraman, Vijay, Shu, Wei, Tashiro, Kyuto, Thompson, Katherine V, Vaarla, Krishniah, Vala, Lakhan, Veselkov, Dennis A, Vo, Jason, Vora, Bhavesh, Wagner, Trixie, Wedel, Laura, Williams, Sarah L, Yendluri, Satya, Yue, Qin, Yifru, Aregahegn, Zhang, Yong, Rivkin, Alexey

“…Herein, we describe the discovery and optimization of a novel series that inhibits bacterial DNA gyrase and topoisomerase IV via binding to, and stabilization…”
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Synthesis of ciprofloxacin dimers for evaluation of bacterial permeability in atypical chemical space by Ross, Audrey G., Benton, Bret M., Chin, Donovan, De Pascale, Gianfranco, Fuller, John, Leeds, Jennifer A., Reck, Folkert, Richie, Daryl L., Vo, Jason, LaMarche, Matthew J.

“…[Display omitted] We describe the synthesis and evaluation of a library of variably-linked ciprofloxacin dimers. These structures unify and expand on the use…”
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Identification of 4-Substituted 1,2,3-Triazoles as Novel Oxazolidinone Antibacterial Agents with Reduced Activity against Monoamine Oxidase A by Reck, Folkert, Zhou, Fei, Girardot, Marc, Kern, Gunther, Eyermann, Charles J, Hales, Neil J, Ramsay, Rona R, Gravestock, Michael B

“…Oxazolidinones represent a new and promising class of antibacterial agents. Current research in this area is mainly concentrated on improving the safety…”
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Target-based resistance in Pseudomonas aeruginosa and Escherichia coli to NBTI 5463, a novel bacterial type II topoisomerase inhibitor by Nayar, Asha S, Dougherty, Thomas J, Reck, Folkert, Thresher, Jason, Gao, Ning, Shapiro, Adam B, Ehmann, David E

“…In a previous report (T. J. Dougherty, A. Nayar, J. V. Newman, S. Hopkins, G. G. Stone, M. Johnstone, A. B. Shapiro, M. Cronin, F. Reck, and D. E. Ehmann,…”
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Exploring Left-Hand-Side substitutions in the benzoxazinone series of 4-amino-piperidine bacterial type IIa topoisomerase inhibitors by Geng, Bolin, Comita-Prevoir, Janelle, Eyermann, Charles J., Reck, Folkert, Fisher, Stewart

“…An SAR survey at the C-6 benzoxazinone position of a novel scaffold which inhibits bacterial type IIa topoisomerase demonstrates that a range of small electron…”
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