Search Results - "Foley, Jason"

Interleukin-2 Activity Can Be Fine Tuned with Engineered Receptor Signaling Clamps by Mitra, Suman, Ring, Aaron M., Amarnath, Shoba, Spangler, Jamie B., Li, Peng, Ju, Wei, Fischer, Suzanne, Oh, Jangsuk, Spolski, Rosanne, Weiskopf, Kipp, Kohrt, Holbrook, Foley, Jason E., Rajagopalan, Sumati, Long, Eric O., Fowler, Daniel H., Waldmann, Thomas A., Garcia, K. Christopher, Leonard, Warren J.

“…Interleukin-2 (IL-2) regulates lymphocyte function by signaling through heterodimerization of the IL-2Rβ and γc receptor subunits. IL-2 is of considerable…”
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Bone Marrow‐Derived Mesenchymal Stromal Cells Harness Purinergenic Signaling to Tolerize Human Th1 Cells In Vivo by Amarnath, Shoba, Foley, Jason E., Farthing, Don E., Gress, Ronald E., Laurence, Arian, Eckhaus, Michael A., Métais, Jean‐Yves, Rose, Jeremy J., Hakim, Frances T., Felizardo, Tania C., Cheng, Austin V., Robey, Pamela G., Stroncek, David E., Sabatino, Marianna, Battiwalla, Minoo, Ito, Sawa, Fowler, Daniel H., Barrett, Austin J.

“…The use of bone marrow‐derived mesenchymal stromal cells (BMSC) in the treatment of alloimmune and autoimmune conditions has generated much interest, yet an…”
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STAT3 Transcription Factor Promotes Instability of nTreg Cells and Limits Generation of iTreg Cells during Acute Murine Graft-versus-Host Disease by Laurence, Arian, Amarnath, Shoba, Mariotti, Jacopo, Kim, Yong Chan, Foley, Jason, Eckhaus, Michael, O'Shea, John J., Fowler, Daniel H.

“…Acute graft-versus-host disease (GvHD) is a major cause of mortality in allogeneic bone marrow transplantation (BMT), for which administration of FoxP3+…”
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Practical high-fidelity frequency-domain force and location identification by Ghaderi, Pooya, Dick, Andrew J., Foley, Jason R., Falbo, Gregory

“…•High fidelity scheme for impact force characterization is presented.•Practical approach using local response behavior and a model of a segment of the…”
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Tbet is a critical modulator of FoxP3 expression in autoimmune graft- versus -host disease by Amarnath, Shoba, Laurence, Arian, Zhu, Nathaniel, Cunha, Renato, Eckhaus, Michael A, Taylor, Samuel, Foley, Jason E, Ghosh, Monalisa, Felizardo, Tania C, Fowler, Daniel H

“…CD4 T-helper subsets drive autoimmune chronic graft- -host disease, a major complication after allogeneic bone marrow transplantation. However, it remains…”
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Mechanical properties of Epon 826/DEA epoxy by Jordan, Jennifer L., Foley, Jason R., Siviour, Clive R.

“…Polymers are becoming increasingly used in aerospace structural applications, where they experience complex, non-static loads. Correspondingly, the mechanical…”
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Compressive properties of extruded polytetrafluoroethylene by Jordan, Jennifer L., Siviour, Clive R., Foley, Jason R., Brown, Eric N.

“…Polymers are becoming increasingly used in aerospace structural applications, where they experience complex, non-static loads. Correspondingly, the mechanical…”
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Association of Serum Interleukin-7 Levels With the Development of Acute Graft-Versus-Host Disease by DEAN, Robert M, FRY, Terry, MACKALL, Crystal, STEINBERG, Seth M, HAKIM, Fran, FOWLER, Daniel, ODOM, Jeanne, FOLEY, Jason, GRESS, Ronald, BISHOP, Michael R

“…Morbidity from acute graft-versus-host disease (GVHD) limits the success of allogeneic hematopoietic stem-cell transplantation (HSCT) to treat malignancy…”
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Activation of Th1 and Tc1 cell adenosine A2A receptors directly inhibits IL-2 secretion in vitro and IL-2-driven expansion in vivo by Erdmann, Andreas A., Gao, Zhan-Guo, Jung, Unsu, Foley, Jason, Borenstein, Todd, Jacobson, Kenneth A., Fowler, Daniel H.

“…To evaluate the direct effect of adenosine on cytokine-polarized effector T cells, murine type 1 helper T cells (Th1) and type 1 cytotoxic T lymphocytes (Tc1)…”
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Host-based Th2 cell therapy for prolongation of cardiac allograft viability by Amarnath, Shoba, Chen, Hao, Foley, Jason E, Costanzo, Carliann M, Sennesh, Joel D, Solomon, Michael A, Fowler, Daniel H

“…Donor T cell transfusion, which is a long-standing approach to prevent allograft rejection, operates indirectly by alteration of host T cell immunity. We…”
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A central role for Foxp3+ regulatory T cells in K-Ras-driven lung tumorigenesis by Granville, Courtney A, Memmott, Regan M, Balogh, Andria, Mariotti, Jacopo, Kawabata, Shigeru, Han, Wei, Lopiccolo, Jaclyn, Foley, Jason, Liewehr, David J, Steinberg, Seth M, Fowler, Daniel H, Hollander, M Christine, Dennis, Phillip A

“…K-Ras mutations are characteristic of human lung adenocarcinomas and occur almost exclusively in smokers. In preclinical models, K-Ras mutations are necessary…”
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Rapamycin generates anti-apoptotic human Th1/Tc1 cells via autophagy for induction of xenogeneic GVHD by Amarnath, Shoba, Flomerfelt, Francis A., Costanzo, Carliann M., Foley, Jason E., Mariotti, Jacopo, Konecki, Daniel M., Gangopadhyay, Anu, Eckhaus, Michael, Wong, Susan, Levine, Bruce L., June, Carl H., Fowler, Daniel H.

“…Murine T cells exposed to rapamycin maintain flexibility towards Th1/Tc1 differentiation, thereby indicating that rapamycin promotion of regulatory T cells…”
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Promoting Outdoor Recreation and Adventure Tourism on the Russell Fork: An Academic-Community Partnership Report by Scott, Shaunna L., McSpirit, Stephanie, Foley, Jason

“…This community note describes a five-year academic-community partnership between a community organization and two universities in Kentucky. It also documents…”
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Calculating scaling function coefficients from system response data for new discrete wavelet families by Dick, Andrew J., Phan, Quan M., Foley, Jason R., Spanos, Pol D.

“…In this paper, a formula derived from the wavelet dilation equation is presented as a means to calculate scaling function coefficient values for arbitrary…”
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Ex Vivo Rapamycin Generates Donor Th2 Cells That Potently Inhibit Graft-versus-Host Disease and Graft-versus-Tumor Effects via an IL-4-Dependent Mechanism by Foley, Jason E, Jung, Unsu, Miera, Angel, Borenstein, Todd, Mariotti, Jacopo, Eckhaus, Michael, Bierer, Barbara E, Fowler, Daniel H

“…Rapamycin (sirolimus) inhibits graft-vs-host disease (GVHD) and polarizes T cells toward Th2 cytokine secretion after allogeneic bone marrow transplantation…”
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CD3/CD28-costimulated T1 and T2 subsets: differential in vivo allosensitization generates distinct GVT and GVHD effects by Jung, Unsu, Foley, Jason E., Erdmann, Andreas A., Eckhaus, Michael A., Fowler, Daniel H.

“…Adoptive T-cell therapy using CD3/CD28 co-stimulation likely requires in vivo generation of antigen specificity. Because CD28 promotes TH1/TC1 (T1) or TH2/TC2…”
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Differential gene expression profile of first-generation and second-generation rapamycin-resistant allogeneic T cells by Castiello, Luciano, Mossoba, Miriam, Viterbo, Antonella, Sabatino, Marianna, Fellowes, Vicki, Foley, Jason E, Winterton, Matthew, Halverson, David C, Civini, Sara, Jin, Ping, Fowler, Daniel H, Stroncek, David F

“…Abstract Background aims We completed a phase II clinical trial evaluating rapamycin-resistant allogeneic T cells (T-rapa) and now have evaluated a T-rapa…”
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Potent induction of B- and T-cell immunity against human carcinoembryonic antigen-expressing tumors in human carcinoembryonic antigen transgenic mice mediated by direct lentivector injection by Loisel-Meyer, Severine, Felizardo, Tania, Mariotti, Jacopo, Mossoba, Miriam E, Foley, Jason E, Kammerer, Robert, Mizue, Nobuo, Keefe, Robert, McCart, J Andrea, Zimmermann, Wolfgang, Dropulic, Boro, Fowler, Daniel H, Medin, Jeffrey A

“…The applicability of immunotherapy would be dramatically broadened to a greater number of recipients if direct “off-the-shelf” products could be engineered to…”
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Tumor Protection Following Vaccination With Low Doses of Lentivirally Transduced DCs Expressing the Self-antigen erbB2 by Mossoba, Miriam E, Walia, Jagdeep S, Rasaiah, Vanessa I, Buxhoeveden, Nicole, Head, Renee, Ying, Chuyan, Foley, Jason E, Bramson, Jonathan L, Fowler, Daniel H, Medin, Jeffrey A

“…Gene therapy strategies may accelerate the development of prophylactic immunotherapy against cancer. We synthesized a lentiviral (LV) vector encoding a…”
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The PDL1-PD1 axis converts human TH1 cells into regulatory T cells by Amarnath, Shoba, Mangus, Courtney W, Wang, James C M, Wei, Fang, He, Alice, Kapoor, Veena, Foley, Jason E, Massey, Paul R, Felizardo, Tania C, Riley, James L, Levine, Bruce L, June, Carl H, Medin, Jeffrey A, Fowler, Daniel H

“…Immune surveillance by T helper type 1 (T(H)1) cells is not only critical for the host response to tumors and infection, but also contributes to autoimmunity…”
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