Search Results - "Foley, JJ"

Identification of a Potent, Selective Non-peptide CXCR2 Antagonist That Inhibits Interleukin-8-induced Neutrophil Migration by White, John R., Lee, Judithann M., Young, Peter R., Hertzberg, Robert P., Jurewicz, Anthony J., Chaikin, Margery A., Widdowson, Katherine, Foley, James J., Martin, Lenox D., Griswold, Don E., Sarau, Henry M.

“…Interleukin-8 (IL-8) and closely related Glu-Leu-Arg (ELR) containing CXC chemokines, including growth-related oncogene (GRO)α, GROβ, GROγ, and epithelial…”
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Cloning and functional characterization of a novel human CC chemokine that binds to the CCR3 receptor and activates human eosinophils by White, John R., Imburgia, Christina, Dul, Edward, Appelbaum, Edward, O'Donnell, Kevin, O'Shannessy, Daniel J., Brawner, Mary, Fornwald, Jim, Adamou, John, Elshourbagy, Nabil A., Kaiser, Kate, Foley, James J., Schmidt, Dulcie B., Johanson, Kyung, Macphee, Colin, Moores, Kitty, McNulty, Dean, Scott, Gilbert F., Schleimer, Robert P., Sarau, Henry M.

“…Eotaxin has been found to bind exclusively to a single chemokine receptor, CCR3. Using expression sequence tag screening of an activated monocyte library, a…”
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Cloning, in Vitro Expression, and Functional Characterization of a Novel Human CC Chemokine of the Monocyte Chemotactic Protein (MCP) Family (MCP-4) That Binds and Signals through the CC Chemokine Receptor 2B by Berkhout, Theo A., Sarau, Henry M., Moores, Kitty, White, John R, Elshourbagy, Nabil, Appelbaum, Edward, Brawner, Theresa J., Reape, Mary, Makwana, Jayneeta, Foley, James J., Schmidt, Dulcie B, Imburgia, Christine, McNulty, Dean, Matthews, Jane, O'Donnell, Kevin, O'Shannessy, Daniel, Scott, Miller, Groot, Pieter H.E., Macphee, Colin

“…Here we describe the characterization of a novel human CC chemokine, tentatively named monocyte chemotactic protein (MCP-4). This chemokine was detected by…”
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Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14 by Ames, Robert S, Sarau, Henry M, Chambers, Johathan K, Willette, Robert N, Aiyar, Nambi V, Romanic, Anne M, Louden, Calvert S, Foley, James J, Sauermelch, Charles F, Coatney, Robert W, Ao, Zhaohui, Disa, Jyoti, Holmes, Stephen D, Stadel, Jeffrey M, Martin, John D, Liu, Wu-Schyong, Glover, George I, Wilson, Shelagh, McNulty, Dean E, Ellis, Catherine E, Elshourbagy, Nabil A, Shabon, Usman, Trill, John J, Hay, Douglas W. P, Ohlstein, Eliot H, Bergsma, Derk J, Douglas, Stephen A

“…Urotensin-II (U-II) is a vasoactive 'somatostatin-like' cyclic peptide which was originally isolated from fish spinal cords, and which has recently been cloned…”
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Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1 by Chambers, Jon, Ames, Robert S, Bergsma, Derk, Muir, Alison, Fitzgerald, Laura R, Hervieu, Guillaume, Dytko, George M, Foley, James J, Martin, John, Liu, Wu-Schyong, Park, Janet, Ellis, Catherine, Ganguly, Subinay, Konchar, Susan, Cluderay, Jane, Leslie, Ron, Wilson, Shelagh, Sarau, Henry M

“…The underlying causes of obesity are poorly understood but probably involve complex interactions between many neurotransmitter and neuropeptide systems…”
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Regulation of TNF‐α and IFN‐γ induced CXCL10 expression: participation of the airway smooth muscle in the pulmonary inflammatory response in chronic obstructive pulmonary disease by Hardaker, Elizabeth L., Bacon, Alicia M., Carlson, Karey, Roshak, Amy K., Foley, James J., Schmidt, Dulcie B., Buckley, Peter T., Comegys, Meghan, Panettieri, Reynold A., Sarau, Henry M., Belmonte, Kristen E.

“…ABSTRACT The chemokine CXCL10 is produced by many inflammatory cells found in the diseased lung and has been implicated in the pathogenesis of chronic…”
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A G Protein-coupled Receptor for UDP-glucose by Chambers, Jon K., Macdonald, Lynn E., Sarau, Henry M., Ames, Robert S., Freeman, Katie, Foley, James J., Zhu, Yuan, McLaughlin, Megan M., Murdock, Paul, McMillan, Lynette, Trill, John, Swift, Ann, Aiyar, Nambi, Taylor, Paul, Vawter, Lisa, Naheed, Sajda, Szekeres, Philip, Hervieu, Guillaume, Scott, Claire, Watson, Jeanette M., Murphy, Andrew J., Duzic, Emir, Klein, Christine, Bergsma, Derk J., Wilson, Shelagh, Livi, George P.

“…Uridine 5′-diphosphoglucose (UDP-glucose) has a well established biochemical role as a glycosyl donor in the enzymatic biosynthesis of carbohydrates. It is…”
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A Potent and Selective Nonpeptide Antagonist of CXCR2 Inhibits Acute and Chronic Models of Arthritis in the Rabbit by Podolin, Patricia L, Bolognese, Brian J, Foley, James J, Schmidt, Dulcie B, Buckley, Peter T, Widdowson, Katherine L, Jin, Qi, White, John R, Lee, Judithann M, Goodman, Richard B, Hagen, Tonja R, Kajikawa, Osamu, Marshall, Lisa A, Hay, Douglas W. P, Sarau, Henry M

“…Much evidence implicates IL-8 as a major mediator of inflammation and joint destruction in rheumatoid arthritis. The effects of IL-8 and its related ligands…”
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Receptor for the Pain Modulatory Neuropeptides FF and AF Is an Orphan G Protein-coupled Receptor by Elshourbagy, N A, Ames, R S, Fitzgerald, L R, Foley, J J, Chambers, J K, Szekeres, P G, Evans, N A, Schmidt, D B, Buckley, P T, Dytko, G M, Murdock, P R, Milligan, G, Groarke, D A, Tan, K B, Shabon, U, Nuthulaganti, P, Wang, D Y, Wilson, S, Bergsma, D J, Sarau, H M

“…Opiate tolerance and dependence are major clinical and social problems. The anti-opiate neuropeptides FF and AF (NPFF and NPAF) have been implicated in pain…”
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Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor by Sarau, H M, Ames, R S, Chambers, J, Ellis, C, Elshourbagy, N, Foley, J J, Schmidt, D B, Muccitelli, R M, Jenkins, O, Murdock, P R, Herrity, N C, Halsey, W, Sathe, G, Muir, A I, Nuthulaganti, P, Dytko, G M, Buckley, P T, Wilson, S, Bergsma, D J, Hay, D W

“…The cysteinyl leukotrienes (CysLTs) have been implicated in the pathophysiology of inflammatory disorders, in particular asthma, for which the CysLT receptor…”
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Identification of a Selective Nonpeptide Antagonist of the Anaphylatoxin C3a Receptor That Demonstrates Antiinflammatory Activity in Animal Models by Ames, Robert S, Lee, Dennis, Foley, James J, Jurewicz, Anthony J, Tornetta, Mark A, Bautsch, Wilfried, Settmacher, Britta, Klos, Andreas, Erhard, Karl F, Cousins, Russell D, Sulpizio, Anthony C, Hieble, J. Paul, McCafferty, Gerald, Ward, Keith W, Adams, Jerry L, Bondinell, William E, Underwood, David C, Osborn, Ruth R, Badger, Alison M, Sarau, Henry M

“…The anaphylatoxin C3a is a potent chemotactic peptide and inflammatory mediator released during complement activation which binds to and activates a…”
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Evaluation of Potent and Selective Small-Molecule Antagonists for the CXCR2 Chemokine Receptor by Widdowson, Katherine L, Elliott, John D, Veber, Daniel F, Nie, Hong, Rutledge, Melvin C, McCleland, Brent W, Xiang, Jia-Ning, Jurewicz, Anthony J, Hertzberg, Robert P, Foley, James J, Griswold, Don E, Martin, Lenox, Lee, Judithann M, White, John R, Sarau, Henry M

“…N,N‘-Diarylureas were prepared, and the structure−activity relationship relative to the CXCR2 receptor was examined. This led to the identification of a potent…”
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Nonpeptidic urotensin‐II receptor antagonists I: in vitro pharmacological characterization of SB‐706375 by Douglas, Stephen A, Behm, David J, Aiyar, Nambi V, Naselsky, Diane, Disa, Jyoti, Brooks, David P, Ohlstein, Eliot H, Gleason, John G, Sarau, Henry M, Foley, James J, Buckley, Peter T, Schmidt, Dulcie B, Wixted, William E, Widdowson, Katherine, Riley, Graham, Jin, Jian, Gallagher, Timothy F, Schmidt, Stanley J, Ridgers, Lance, Christmann, Lisa T, Keenan, Richard M, Knight, Steven D, Dhanak, Dashyant

“…1 SB‐706375 potently inhibited [125I]hU‐II binding to both mammalian recombinant and ‘native’ UT receptors (Ki 4.7±1.5 to 20.7±3.6 nM at rodent, feline and…”
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Molecular Cloning and Characterization of the Human Anaphylatoxin C3a Receptor by Ames, Robert S., Li, Yi, Sarau, Henry M., Nuthulaganti, Paru, Foley, James J., Ellis, Catherine, Zeng, Zhizhen, Su, Kui, Jurewicz, Anthony J., Hertzberg, Robert P., Bergsma, Derk J., Kumar, Chandrika

“…In a human neutrophil cDNA library, an orphan G-protein-coupled receptor, HNFAG09, with 37% nucleotide identity to the C5a receptor (C5a-R, CD88) was…”
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Identification of Potent, Selective Non-peptide CC Chemokine Receptor-3 Antagonist That Inhibits Eotaxin-, Eotaxin-2-, and Monocyte Chemotactic Protein-4-induced Eosinophil Migration by White, John R., Lee, Judithann M., Dede, Kimberly, Imburgia, Christina S., Jurewicz, Anthony J., Chan, George, Fornwald, James A., Dhanak, Dashyant, Christmann, Lisa T., Darcy, Michael G., Widdowson, Katherine L., Foley, James J., Schmidt, Dulcie B., Sarau, Henry M.

“…Eosinophils have been implicated in the pathogenesis of asthma and other allergic diseases. Several CC chemokines including eotaxin (CCL-11), eotaxin-2…”
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Neuromedin U elicits cytokine release in murine Th2-type T cell clone D10.G4.1 by Johnson, Eric N, Appelbaum, Edward R, Carpenter, Donald C, Cox, Richard F, Disa, Jyoti, Foley, James J, Ghosh, Sujoy K, Naselsky, Diane P, Pullen, Mark A, Sarau, Henry M, Scheff, Samuel R, Steplewski, Klaudia M, Zaks-Zilberman, Meirav, Aiyar, Nambi

“…Neuromedin U (NmU), originally isolated from porcine spinal cord and later from other species, is a novel peptide that potently contracts smooth muscle. NmU…”
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The neuromedin B receptor antagonist, BIM‐23127, is a potent antagonist at human and rat urotensin‐II receptors by Herold, Christopher L, Behm, David J, Buckley, Peter T, Foley, James J, Wixted, William E, Sarau, Henry M, Douglas, Stephen A

“…The functional activity of the peptidic neuromedin B receptor antagonist BIM‐23127 was investigated at recombinant and native urotensin‐II receptors (UT…”
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Nonpeptide tachykinin receptor antagonists. III. SB 235375, a low central nervous system-penetrant, potent and selective neurokinin-3 receptor antagonist, inhibits citric acid-induced cough and airways hyper-reactivity in guinea pigs by Hay, Douglas W P, Giardina, Giuseppe A M, Griswold, Don E, Underwood, David C, Kotzer, Charles J, Bush, Brian, Potts, William, Sandhu, Punam, Lundberg, Dave, Foley, James J, Schmidt, Dulcie B, Martin, Lenox D, Kilian, David, Legos, Jeffrey J, Barone, Frank C, Luttmann, Mark A, Grugni, Mario, Raveglia, Luca F, Sarau, Henry M

“…In this report the in vitro and in vivo pharmacological and pharmacokinetic profile of…”
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Identification and molecular characterization of rat CXCR3: receptor expression and interferon-inducible protein-10 binding are increased in focal stroke by Wang, X, Li, X, Schmidt, D B, Foley, J J, Barone, F C, Ames, R S, Sarau, H M

“…We describe here the cloning and characterization of a rat homolog of the chemokine receptor CXCR3. The predicted amino acid sequence of rat CXCR3 contains 367…”
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Calmodulin-Binding Peptide PEP-19 Modulates Activation of Calmodulin Kinase II In Situ by Johanson, Roy A, Sarau, Henry M, Foley, James J, Slemmon, J. Randall

“…PEP-19 is a 6 kDa polypeptide that is highly expressed in select populations of neurons that sometimes demonstrate resistance to degeneration. These include…”
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