Search Results - "Foley, Caroline A"

Assessing the Cell Permeability of Bivalent Chemical Degraders Using the Chloroalkane Penetration Assay by Foley, Caroline A, Potjewyd, Frances, Lamb, Kelsey N, James, Lindsey I, Frye, Stephen V

“…Bivalent chemical degraders provide a catalytic route to selectively degrade disease-associated proteins. By linking target-specific ligands with E3 ubiquitin…”
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Cdyl Deficiency Brakes Neuronal Excitability and Nociception through Promoting Kcnb1 Transcription in Peripheral Sensory Neurons by Sun, Zhao‐Wei, Waybright, Jarod M., Beldar, Serap, Chen, Lu, Foley, Caroline A., Norris‐Drouin, Jacqueline L., Lyu, Tian‐Jie, Dong, Aiping, Min, Jinrong, Wang, Yu‐Pu, James, Lindsey I., Wang, Yun

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Cdyl Deficiency Brakes Neuronal Excitability and Nociception through Promoting Kcnb1 Transcription in Peripheral Sensory Neurons by Sun, Zhao‐Wei, Waybright, Jarod M., Beldar, Serap, Chen, Lu, Foley, Caroline A., Norris‐Drouin, Jacqueline L., Lyu, Tian‐Jie, Dong, Aiping, Min, Jinrong, Wang, Yu‐Pu, James, Lindsey I., Wang, Yun

“…Epigenetic modifications are involved in the onset, development, and maintenance of pain; however, the precise epigenetic mechanism underlying pain regulation…”
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Synthesis and Structure–Activity Relationships of 1‑Aryl-β-carbolines as Affinity Probes for the 5‑Hydroxytryptamine Receptor by Foley, Caroline A, Al-Issa, Yazan A, Hiller, Kathryn P, Mulcahy, Seann P

“…Simple β-carbolines have been shown to bind several protein receptors that are important for signaling in the central nervous system. Herein, we expand our…”
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The histone and non-histone methyllysine reader activities of the UHRF1 tandem Tudor domain are dispensable for the propagation of aberrant DNA methylation patterning in cancer cells by Vaughan, Robert M, Kupai, Ariana, Foley, Caroline A, Sagum, Cari A, Tibben, Bailey M, Eden, Hope E, Tiedemann, Rochelle L, Berryhill, Christine A, Patel, Varun, Shaw, Kevin M, Krajewski, Krzysztof, Strahl, Brian D, Bedford, Mark T, Frye, Stephen V, Dickson, Bradley M, Rothbart, Scott B

“…The chromatin-binding E3 ubiquitin ligase ubiquitin-like with PHD and RING finger domains 1 (UHRF1) contributes to the maintenance of aberrant DNA methylation…”
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Discovery of hit compounds for methyl-lysine reader proteins from a target class DNA-encoded library by Shell, Devan J., Rectenwald, Justin M., Buttery, Peter H., Johnson, Rebecca L., Foley, Caroline A., Guduru, Shiva K.R., Uguen, Mélanie, Rubiano, Juanita Sanchez, Zhang, Xindi, Li, Fengling, Norris-Drouin, Jacqueline L., Axtman, Matthew, Brian Hardy, P., Vedadi, Masoud, Frye, Stephen V., James, Lindsey I., Pearce, Kenneth H.

“…•Focused DNA-encoded libraries (DELs) are effective in target class hit discovery.•Reader domains of five methyl-lysine reader proteins screened using a…”
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Improved methods for targeting epigenetic reader domains of acetylated and methylated lysine by Engelberg, Isabelle A., Foley, Caroline A., James, Lindsey I., Frye, Stephen V.

“…Responsible for interpreting histone post-translational modifications, epigenetic reader proteins have emerged as novel therapeutic targets for a wide range of…”
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Discovery of a 53BP1 Small Molecule Antagonist Using a Focused DNA-Encoded Library Screen by Shell, Devan J., Foley, Caroline A., Wang, Qinhong, Smith, Chelsea M., Guduru, Shiva K. R., Zeng, Hong, Dong, Aiping, Norris-Drouin, Jacqueline L., Axtman, Matthew, Hardy, P. Brian, Gupta, Gaorav, Halabelian, Levon, Frye, Stephen V., James, Lindsey I., Pearce, Kenneth H.

“…Methyl-lysine reader p53 binding protein 1 (53BP1) is a central mediator of DNA break repair and is associated with various human diseases, including cancer…”
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Structural basis of paralog-specific KDM2A/B nucleosome recognition by Spangler, Cathy J., Skrajna, Aleksandra, Foley, Caroline A., Nguyen, Anh, Budziszewski, Gabrielle R., Azzam, Dalal N., Arteaga, Eyla C., Simmons, Holly C., Smith, Charlotte B., Wesley, Nathaniel A., Wilkerson, Emily M., McPherson, Jeanne-Marie E., Kireev, Dmitri, James, Lindsey I., Frye, Stephen V., Goldfarb, Dennis, McGinty, Robert K.

“…The nucleosome acidic patch is a major interaction hub for chromatin, providing a platform for enzymes to dock and orient for nucleosome-targeted activities…”
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PROTAC Linkerology Leads to an Optimized Bivalent Chemical Degrader of Polycomb Repressive Complex 2 (PRC2) Components by Bashore, Frances M., Foley, Caroline A., Ong, Han Wee, Rectenwald, Justin M., Hanley, Ronan P., Norris-Drouin, Jacqueline L., Cholensky, Stephanie H., Mills, Christine A., Pearce, Kenneth H., Herring, Laura E., Kireev, Dmitri, Frye, Stephen V., James, Lindsey I.

“…Bivalent chemical degraders, otherwise known as proteolysis-targeting chimeras (PROTACs), have proven to be an efficient strategy for targeting overexpressed…”
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Bioorthogonal Chemical Epigenetic Modifiers Enable Dose-Dependent CRISPR Targeted Gene Activation in Mammalian Cells by Lu, Dongbo, Foley, Caroline A, Birla, Shama V, Hepperla, Austin J, Simon, Jeremy M, James, Lindsey I, Hathaway, Nathaniel A

“…CRISPR-Cas9 systems have been developed to regulate gene expression by using either fusions to epigenetic regulators or, more recently, through the use of…”
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Royal Commission on Labour. The Employment of Women by Foley, Caroline A.

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The Vedalla Sutta, as Illustrating the Psychological Basis of Buddhist Ethics by Foley, Caroline A.

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Fashion by Foley, Caroline A.

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Fashion by Foley, Caroline A.

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Fashion by Foley, Caroline A

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Art. XII.—The Vedalla Sutta, as illustrating the Psychological Basis of Buddhist Ethics by Foley, Caroline A.

“…The two Suttas entitled Mahāvedalla and Cūḷavedalla are the 43rd and 44th in the Mūlapaṇṇāsaṁ, or first division of the Majjhima Nikāya, the second book of the…”
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4. Correspondence by Foley, Caroline A.

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Letter from Caroline A. Foley by Foley, Caroline A.

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VI.—CRITICAL NOTICES by FOLEY, CAROLINE A.

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