Search Results - "Foley, Briana E"

Discovery of benzamide tetrahydro-4H-carbazol-4-ones as novel small molecule inhibitors of Hsp90 by BARTA, Thomas E, VEAL, James M, BARABASZ, Amy F, FOLEY, Briana E, OTTO, James, HALL, Steven E, RICE, John W, PARTRIDGE, Jeffrey M, FADDEN, R. Patrick, WEI MA, JENKS, Matthew, LIFENG GENG, HANSON, Gunnar J, HUANG, Kenneth H

“…Hsp90 maintains the conformational stability of multiple proteins implicated in oncogenesis and has emerged as a target for chemotherapy. We report here the…”
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Discovery of novel aminoquinazolin-7-yl 6,7-dihydro-indol-4-ones as potent, selective inhibitors of heat shock protein 90 by Huang, Kenneth H., Barta, Thomas E., Rice, John W., Smith, Emilie D., Ommen, Andy J., Ma, Wei, Veal, James M., Fadden, R. Patrick, Barabasz, Amy F., Foley, Briana E., Hughes, Philip F., Hanson, Gunnar J., Markworth, Christopher J., Silinski, Melanie, Partridge, Jeffrey M., Steed, Paul M., Hall, Steven E.

“…Compound affinity to Hsp90 in Kd and cellular activities in IC50. A novel class of Hsp90 inhibitors, structurally distinct from previously reported scaffolds,…”
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Novel carbazole and acyl-indole antimitotics by Barta, Thomas E., Barabasz, Amy F., Foley, Briana E., Geng, Lifeng, Hall, Steven E., Hanson, Gunnar J., Jenks, Matthew, Ma, Wei, Rice, John W., Veal, James

“…In the course of our Heat Shock 90 program, certain carbazole compounds were identified which had an off-target antiproliferative activity. To understand the…”
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Discovery of Novel 2-Aminobenzamide Inhibitors of Heat Shock Protein 90 as Potent, Selective and Orally Active Antitumor Agents by Huang, Kenneth H, Veal, James M, Fadden, R. Patrick, Rice, John W, Eaves, Jeron, Strachan, Jon-Paul, Barabasz, Amy F, Foley, Briana E, Barta, Thomas E, Ma, Wei, Silinski, Melanie A, Hu, Mei, Partridge, Jeffrey M, Scott, Anisa, DuBois, Laura G, Freed, Tiffany, Steed, Paul M, Ommen, Andy J, Smith, Emilie D, Hughes, Philip F, Woodward, Angela R, Hanson, Gunnar J, McCall, W. Stephen, Markworth, Christopher J, Hinkley, Lindsay, Jenks, Matthew, Geng, Lifeng, Lewis, Meredith, Otto, James, Pronk, Bert, Verleysen, Katleen, Hall, Steven E

“…A novel class of heat shock protein 90 (Hsp90) inhibitors was developed from an unbiased screen to identify protein targets for a diverse compound library…”
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Discovery of benzamide tetrahydro-4 H-carbazol-4-ones as novel small molecule inhibitors of Hsp90 by Barta, Thomas E., Veal, James M., Rice, John W., Partridge, Jeffrey M., Fadden, R. Patrick, Ma, Wei, Jenks, Matthew, Geng, Lifeng, Hanson, Gunnar J., Huang, Kenneth H., Barabasz, Amy F., Foley, Briana E., Otto, James, Hall, Steven E.

“…Hsp90 maintains the conformational stability of multiple proteins implicated in oncogenesis and has emerged as a target for chemotherapy. We report here the…”
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