Search Results - "Fokko van Loo, Pieter"

Btk levels set the threshold for B-cell activation and negative selection of autoreactive B cells in mice by Kil, Laurens P., de Bruijn, Marjolein J.W., van Nimwegen, Menno, Corneth, Odilia B.J., van Hamburg, Jan Piet, Dingjan, Gemma M., Thaiss, Friedrich, Rimmelzwaan, Guus F., Elewaut, Dirk, Delsing, Dianne, van Loo, Pieter Fokko, Hendriks, Rudi W.

“…On antigen binding by the B-cell receptor (BCR), B cells up-regulate protein expression of the key downstream signaling molecule Bruton tyrosine kinase (Btk),…”
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Transcription Factor Sp3 Knockout Mice Display Serious Cardiac Malformations by van Loo, Pieter Fokko, Mahtab, Edris A. F., Wisse, Lambertus J., Hou, Jun, Grosveld, Frank, Suske, Guntram, Philipsen, Sjaak, Gittenberger-de Groot, Adriana C.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Bruton's Tyrosine Kinase and SLP-65 Regulate Pre-B Cell Differentiation and the Induction of Ig Light Chain Gene Rearrangement by Kersseboom, Rogier, Ta, Van B. T, Zijlstra, A. J. Esther, Middendorp, Sabine, Jumaa, Hassan, Fokko van Loo, Pieter, Hendriks, Rudolf W

“…Bruton's tyrosine kinase (Btk) and the adapter protein SLP-65 (Src homology 2 domain-containing leukocyte-specific phosphoprotein of 65 kDa) transmit precursor…”
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Impaired hematopoiesis in mice lacking the transcription factor Sp3 by van Loo, Pieter Fokko, Bouwman, Peter, Ling, Kam-Wing, Middendorp, Sabine, Suske, Guntram, Grosveld, Frank, Dzierzak, Elaine, Philipsen, Sjaak, Hendriks, Rudolf W.

“…As the zinc-finger transcription factor specificity protein 3 (Sp3) has been implicated in the regulation of many hematopoietic-specific genes, we analyzed the…”
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A human CD137×PD-L1 bispecific antibody promotes anti-tumor immunity via context-dependent T cell costimulation and checkpoint blockade by Geuijen, Cecile, Tacken, Paul, Wang, Liang-Chuan, Klooster, Rinse, van Loo, Pieter Fokko, Zhou, Jing, Mondal, Arpita, Liu, Yao-bin, Kramer, Arjen, Condamine, Thomas, Volgina, Alla, Hendriks, Linda J. A., van der Maaden, Hans, Rovers, Eric, Engels, Steef, Fransen, Floris, den Blanken-Smit, Renate, Zondag-van der Zande, Vanessa, Basmeleh, Abdul, Bartelink, Willem, Kulkarni, Ashwini, Marissen, Wilfred, Huang, Cheng-Yen, Hall, Leslie, Harvey, Shane, Kim, Soyeon, Martinez, Marina, O’Brien, Shaun, Moon, Edmund, Albelda, Steven, Kanellopoulou, Chrysi, Stewart, Shaun, Nastri, Horacio, Bakker, Alexander B. H., Scherle, Peggy, Logtenberg, Ton, Hollis, Gregory, de Kruif, John, Huber, Reid, Mayes, Patrick A., Throsby, Mark

“…Immune checkpoint inhibitors demonstrate clinical activity in many tumor types, however, only a fraction of patients benefit. Combining CD137 agonists with…”
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MCLA-117, a CLEC12AxCD3 bispecific antibody targeting a leukaemic stem cell antigen, induces T cell-mediated AML blast lysis by van Loo, Pieter Fokko, Hangalapura, Basav N, Thordardottir, Soley, Gibbins, John D, Veninga, Henrike, Hendriks, Linda J A, Kramer, Arjen, Roovers, Rob C, Leenders, Marij, de Kruif, John, Doornbos, Robert P, Sirulnik, Andres, Throsby, Mark, Logtenberg, Ton, Dolstra, Harry, Bakker, Alexander B H

“…: We report the characterization of MCLA-117, a novel T cell-redirecting antibody for acute myeloid leukaemia (AML) treatment targeting CD3 on T cells and…”
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Preclinical Evaluation of MCLA117, a CLEC12AxCD3 Bispecific Antibody Efficiently Targeting a Novel Leukemic Stem Cell Associated Antigen in AML by Van Loo, Pieter Fokko, Doornbos, Robert, Dolstra, Harry, Shamsili, Setareh, Bakker, Lex

“…Although chemotherapy regimens induce initial remissions in most acute myeloid leukemia (AML) patients, their long term prognosis is very poor. Novel targeted…”
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Abstract 539: A bispecific Fc-silenced IgG1 antibody (MCLA-145) requires PD-L1 binding to activate CD137 by Mayes, Patrick, Tacken, Paul, Wang, Steve, Loo, Pieter-Fokko van, Condamine, Thomas, Maaden, Hans van der, Rovers, Eric, Engels, Steef, Fransen, Floris, Kulkarni, Ashwini, Liu, Yao-bin, Mondal, Arpita, Hall, Leslie, Kim, Soyeon, Martinez, Marina, O'Brien, Shaun, Moon, Edmund, Albelda, Steven, Scherle, Peggy, Hollis, Gregory, Huber, Reid, Throsby, Mark, Geuijen, Cecile A.

“…CD137 (4-1BB) is a transmembrane costimulatory receptor on T and NK cells that enhances adaptive immune responses and is a critical mediator of antitumor…”
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Surrogate-Light-Chain Silencing Is Not Critical for the Limitation of Pre-B Cell Expansion but Is for the Termination of Constitutive Signaling by van Loo, Pieter Fokko, Dingjan, Gemma M., Maas, Alex, Hendriks, Rudi W.

“…The pre-B cell receptor (pre-BCR), composed of immunoglobulin μ heavy chain and the surrogate light chain (SLC) proteins λ5 and Vpreb, signals for…”
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Abstract LB-261: Mechanism of action of MCLA-128, a humanized bispecific IgG1 antibody targeting the HER2:HER3 heterodimer by Geuijen, Cecile, Rovers, Eric, Gallenne, Tristan, Maussang-Detaille, David, Kramer, Arjen, Nieuwenhuizen, Nellie, Clements, Carina, van Zoest, Katinka, Nijhuis, Roy, Visser, Therese, Den Blanken-Smit, Renate, Bartelink, Willem, Zondag-van der Zande, Vanessa, Kaldenberg, Linda, van Loo, Pieter-Fokko, Roovers, Rob, Doornbos, Robert, Price, Leo, Braam, Stefan, van Driel, Setareh, Bakker, Lex, Logtenberg, Ton, de Kruif, John, Throsby, Mark

“…Background: MCLA-128 is an ADCC-enhanced humanized common light chain bispecific IgG1 antibody that targets the HER2:HER3 dimer with nanomolar affinity,…”
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Preclinical activity of MCLA-128, an ADCC enhanced bispecific IgG1 antibody targeting the HER2:HER3 heterodimer by Geuijen, Cecile, Rovers, Eric, Nijhuis, Roy, den Blanken-Smit, Renate, Visser, Therese, Bartelink, Willem, Kramer, Arjen, Zondag-van der Zande, Vanessa, Clements, Carina, Kaldenberg, Linda, Nieuwenhuizen, Nellie, van Loo, Pieter Fokko, Roovers, Rob, Gallenne, Tristan, Price, Leo, Van Driel Shamsili, Setareh, Bakker, Lex, Logtenberg, Ton, de Kruif, John, Throsby, Mark

“…Abstract only…”
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Surrogate light chain expression beyond the pre-B cell stage promotes tolerance in a dose-dependent fashion by Kil, Laurens P, Corneth, Odilia B.J, de Bruijn, Marjolein J.W, Asmawidjaja, Patrick S, Krause, Arndt, Lubberts, Erik, van Loo, Pieter Fokko, Hendriks, Rudi W

“…Abstract While surrogate light chain (SLC) expression is normally terminated in differentiating pre-B cells, co-expression of SLC and conventional light chains…”
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820 MCLA-145 is a bispecific IgG1 antibody that inhibits PD-1/PD-L1 signaling while simultaneously activating CD137 signaling on T cells by Tacken, Paul, Wang, Liang-chuan, Klooster, Rinse, Loo, Pieter Fokko Van, Zhou, Jing, Mondal, Arpita, Liu, Yao-Bin, Kramer, Arjen, Condamine, Thomas, Volgina, Alla, Hendriks, Linda, Maaden, Hans van der, Rovers, Eric, Engels, Steef, Fransen, Floris, Blanken-Smit, Renate den, Zande, Vanessa Zondag-van der, Basmeleh, Abdul, Bartelink, Willem, Kulkarni, Ashwini, Marissen, Wilfred, Huang, Cheng-Yen, Hall, Leslie, Harvey, Shane, Kanellopoulou, Chrysi, Stewart, Shaun, Nastri, Horacio, Bakker, Lex, Logtenberg, Ton, Plyte, Simon, Mayes, Patrick, Throsby, Mark, Geuijen, Cecile

“…BackgroundMCLA-145 is a CD137 x PD-L1 bispecific antibody that releases PD-L1 mediated T-cell inhibition and activates and expands T cells through agonism of…”
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Malignant transformation of Slp65-deficient pre-B cells involves disruption of the Arf-Mdm2-p53 tumor suppressor pathway by Ta, Van B.T., de Bruijn, Marjolein J.W., ter Brugge, Petra J., van Hamburg, Jan Piet, Diepstraten, Hans J.A., van Loo, Pieter Fokko, Kersseboom, Rogier, Hendriks, Rudi W.

“…The adapter protein Slp65 is a key component of the precursor-B (pre-B) cell receptor. Slp65-deficient mice spontaneously develop pre-B cell leukemia, but the…”
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Highly B lymphocyte-specific tamoxifen inducible transgene expression of CreER T2 by using the LC-1 locus BAC vector by Boross, Peter, Breukel, Cor, van Loo, Pieter Fokko, van der Kaa, Jos, Claassens, Jill W, Bujard, Hermann, Schönig, Kai, Verbeek, J Sjef

“…The generation of cell type specific inducible Cre transgenic mice is the most challenging and limiting part in the development of spatio-temporally controlled…”
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Highly B lymphocyte-specific tamoxifen inducible transgene expression of CreERT2 by using the LC-1 locus BAC vector by Boross, Peter, Breukel, Cor, van Loo, Pieter Fokko, van der Kaa, Jos, Claassens, Jill W., Bujard, Hermann, Schönig, Kai, Verbeek, J. Sjef

“…The generation of cell type specific inducible Cre transgenic mice is the most challenging and limiting part in the development of spatio‐temporally controlled…”
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