Search Results - "Fok, Kam F"

Employing a superior BACE1 cleavage sequence to probe cellular APP processing by Tomasselli, Alfredo G., Qahwash, Isam, Emmons, Thomas L., Lu, Yifeng, Leone, Joseph W., Lull, June M., Fok, Kam F., Bannow, Carol A., Smith, Clark W., Bienkowski, Michael J., Heinrikson, Robert L., Yan, Riqiang

“…The involvement of β‐secretase (BACE1; β‐site APP‐cleaving enzyme) in producing the β‐amyloid component of plaques found in the brains of Alzheimer's patients,…”
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Purification and Sequence Analysis of Bioactive Atrial Peptides (Atriopeptins) by Currie, Mark G., Geller, David M., Cole, Barbara R., Siegel, Ned R., Fok, Kam F., Adams, Steven P., Eubanks, Shad R., Galluppi, Gerald R., Needleman, Philip

“…Mammalian cardiac atria have several biologically active peptides that exert profound effects on sodium excretion, urine volume, and smooth muscle tone. In the…”
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Guanylin: An Endogenous Activator of Intestinal Guanylate Cyclase by Currie, Mark G., Fok, Kam F., Kato, Johji, Moore, Rosalyn J., Hamra, Franklin K., Duffin, Kevin L., Smith, Christine E.

“…Intestinal guanylate cyclase mediates the action of the heat-stable enterotoxin to cause a decrease in intestinal fluid absorption and to increase chloride…”
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Uroguanylin: Structure and Activity of a Second Endogenous Peptide that Stimulates Intestinal Guanylate Cyclase by Hamra, F. Kent, Forte, Leonard R., Eber, Sammy L., Pidhorodeckyj, Nykolai V., Krause, William J., Freeman, Ronald H., Chin, David T., Tompkins, Jay A., Fok, Kam F., Smith, Christine E., Duffin, Kevin L., Siegel, Ned R., Currie, Mark G.

“…The intestinal hormone guanylin and bacterial heat-stable enterotoxins (STs) are members of a peptide family that activates intestinal membrane guanylate…”
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A high performance liquid chromatography assay for monitoring proprotein convertase activity by Hall, Troii, Fok, Kam F., Liu, Min M., Zobel, James F., Marino, Margaret H., Malfait, Anne-Marie, Tortorella, Micky D., Tomasselli, Alfredo G.

“…A rapid HPLC assay was developed for monitoring the activity of the two proprotein convertases, PACE-4 and furin. Six novel peptide substrates were synthesized…”
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2-Iminopiperidine and Other 2-Iminoazaheterocycles as Potent Inhibitors of Human Nitric Oxide Synthase Isoforms by Moore, William M, Webber, R. Keith, Fok, Kam F, Jerome, Gina M, Connor, Jane R, Manning, Pamela T, Wyatt, Pamela S, Misko, Thomas P, Tjoeng, Foe S, Currie, Mark G

“…A series of 2-iminoazaheterocycles have been prepared and shown to be potent inhibitors of human nitric oxide synthase (NOS) isoforms. This series includes…”
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2-Iminopyrrolidines as Potent and Selective Inhibitors of Human Inducible Nitric Oxide Synthase by Hagen, Timothy J, Bergmanis, Arija A, Kramer, Steven W, Fok, Kam F, Schmelzer, Albert E, Pitzele, Barnett S, Swenton, Lydia, Jerome, Gina M, Kornmeier, Christine M, Moore, William M, Branson, Linda F, Connor, Jane R, Manning, Pamela T, Currie, Mark G, Hallinan, E. Ann

“…A series of substituted 2-iminopyrrolidines has been prepared and shown to be potent and selective inhibitors of the human inducible nitric oxide synthase…”
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Substituted 2-Iminopiperidines as Inhibitors of Human Nitric Oxide Synthase Isoforms by Webber, R. Keith, Metz, Suzanne, Moore, William M, Connor, Jane R, Currie, Mark G, Fok, Kam F, Hagen, Timothy J, Hansen, Donald W, Jerome, Gina M, Manning, Pamela T, Pitzele, Barnett S, Toth, Mihaly V, Trivedi, Mahima, Zupec, Mark E, Tjoeng, F. Siong

“…A series of analogues of 2-iminopiperidine have been prepared and shown to be potent inhibitors of the human nitric oxide synthase (NOS) isoforms. Methyl…”
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Identification of an allatostatin from adult Diploptera punctata by Pratt, G E, Farnsworth, D E, Siegel, N R, Fok, K F, Feyereisen, R

“…A peptide (allatostatin) causing strong and rapid inhibition of juvenile hormone synthesis in vitro by corpora allata from reproductively active females has…”
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Examination of the kinetic mechanism of mitogen-activated protein kinase activated protein kinase-2 by Schindler, John F, Godbey, Andrew, Hood, William F, Bolten, Suzanne L, Broadus, Richard M, Kasten, Thomas P, Cassely, Aaron J, Hirsch, Jeffery L, Merwood, Michelle A, Nagy, Mark A, Fok, Kam F, Saabye, Matthew J, Morgan, Heidi M, Compton, Robert P, Mourey, Robert J, Wittwer, Arthur J, Monahan, Joseph B

“…The kinetic mechanism of mitogen-activated protein kinase activated protein kinase-2 (MAPKAPK2) was investigated using a peptide (LKRSLSEM) based on the…”
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Human guanylin: cDNA isolation, structure, and activity by Wiegand, Roger C., Kato, Johji, Huang, Margaret D., Fok, Kam F., Kachur, James F., Currie, Mark G.

“…Guanylin is a mammalian peptide homologue of heat-stable enterotoxins that acts on intestinal guanylate cyclase to elicit an increase in cyclic GMP. We have…”
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Ser-Leu-Arg-Arg--Atriopeptin III: The Major Circulating Form of Atrial Peptide by Schwartz, David, Geller, David M., Manning, Pamela T., Siegel, Ned R., Fok, Kam F., Smith, Christine E., Needleman, Philip

“…Vasopressin induces a concentration-dependent increase in atriopeptin immunoreactivity in plasma. Rat plasma, rat atrial extract, and synthetic atriopeptin III…”
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Structure–activity studies reveal two allatostatin receptor types in corpora allata of Diploptera punctata by Pratt, Grahame E, Chandran Unnithan, G, Fok, Kam F, Siegel, Ned R, Feyereisen, R

“…Synthetic variants of the octadecapeptide amide ASB2 (AYSYVSEYKRLPVYNFGL-NH 2), a cockroach allatostatin, were assayed in vitro on corpora allata (CA) from…”
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Identification of a tetrapeptide recognition sequence for the α2β1 integrin in collagen by STAATZ, W. D, FOK, K. F, ZUTTER, M. M, ADAMS, S. P, RODRIGUEZ, B. A, SANTORO, S. A

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Guanylin stimulation of Cl- secretion in human intestinal T84 cells via cyclic guanosine monophosphate by FORTE, L. R, EBER, S. L, TURNER, J. T, FREEMAN, R. H, FOK, K. F, CURRIE, M. G

“…Intestinal salt and fluid secretion is stimulated by Escherichia coli heat-stable enterotoxins (ST) through activation of a membrane guanylate cyclase found in…”
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Characterization of human uroguanylin: a member of the guanylin peptide family by Kita, T, Smith, C E, Fok, K F, Duffin, K L, Moore, W M, Karabatsos, P J, Kachur, J F, Hamra, F K, Pidhorodeckyj, N V, Forte, L R

“…Guanylin, a peptide homologue of the bacterial heat-stable enterotoxins (ST), is an endogenous activator of guanylate cyclase C (GC-C). We have initiated a…”
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Inhibitors of human nitric oxide synthase isoforms with the carbamidine moiety as a common structural element by Moore, William M., Keith Webber, R., Fok, Kam F., Jerome, Gina M., Kornmeier, Christine M., Tjoeng, Foe S., Currie, Mark G.

“…Identification of potent and selective inhibitors of inducible nitric oxide synthase (NOS) is of great interest because of their therapeutic potential for…”
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Effects of endothelin on regional hemodynamics in conscious rats by Han, S P, Trapani, A J, Fok, K F, Westfall, T C, Knuepfer, M M

“…Endothelin is a potent vasoactive peptide in anesthetized rats and isolated vascular smooth muscle. This study was performed to describe the hemodynamic…”
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Alpha 2-antiplasmin's carboxy-terminal lysine residue is a major site of interaction with plasmin by Hortin, G L, Gibson, B L, Fok, K F

“…alpha 2-Antiplasmin (AP) inhibits plasmin in a two-step reaction in which AP reversibly binds to lysine-binding sites of plasmin and, then, more slowly…”
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Comparative Vascular Pharmacology of the Atriopeptins by Wakitani, Korekiyo, Oshima, Takeshi, Loewy, Arthur D, Holmberg, Sandra W, Cole, Barbara R, Adams, Steven P, Fok, Kam F, Currie, Mark G, Needleman, Philip

“…The atriopeptins are potent relaxants of norepinephrine-constricted aortic strips or are dilators of renal blood vessels in isolated perfused rat kidneys that…”
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