Search Results - "Fojo, A T"

Expression of a Multidrug-Resistance Gene in Human Tumors and Tissues by Fojo, A. T., Ueda, K., Slamon, D. J., Poplack, D. G., Gottesman, M. M., Pastan, I.

“…The identification and cloning of a segment of a human multidrug resistance gene (mdr1) was reported recently. To examine the molecular basis of one type of…”
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LYMPH NODE AND SKIN SCORING GROWTH KINETICS PREDICT OUTCOMES IN CUTANEOUS T‐CELL LYMPHOMA: AN INTERIM ANALYSIS by Fahmy, L. M., Yang, H. R., Zhou, M., Beylergil, V., Schreidah, C. M., Kwinta, B. D., Schwartz, L. H., Fojo, A. T., Bates, S. E., Geskin, L. J.

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Rhodamine efflux patterns predict P-glycoprotein substrates in the National Cancer Institute drug screen by Lee, J S, Paull, K, Alvarez, M, Hose, C, Monks, A, Grever, M, Fojo, A T, Bates, S E

“…Fifty-eight cell lines in the National Cancer Institute drug screen were analyzed for their ability to efflux the fluorescent dye rhodamine 123 as a functional…”
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Increased mdr-1/P-glycoprotein expression after treatment of human colon carcinoma cells with P-glycoprotein antagonists by HERZOG, C. E, TSOKOS, M, BATES, S. E, FOJO, A. T

“…We observed increased levels of mdr-1 mRNA and its protein product P-glycoprotein (Pgp) in the human colon carcinoma cell line, LS 180, and its drug-resistant…”
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Modulation of the expression of a multidrug resistance gene (mdr-1/P-glycoprotein) by differentiating agents by Mickley, L A, Bates, S E, Richert, N D, Currier, S, Tanaka, S, Foss, F, Rosen, N, Fojo, A T

“…Acquired resistance to multiple natural products in vitro is mediated by P-glycoprotein (Pgp). Expression of this protein has been demonstrated in some normal…”
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Metallothionein gene expression and resistance to cisplatin in human ovarian cancer by Schilder, R J, Hall, L, Monks, A, Handel, L M, Fornace, Jr, A J, Ozols, R F, Fojo, A T, Hamilton, T C

“…Intracellular thiols have been proposed as mediators of resistance to alkylating agents and cisplatin. As metallothionein is the predominant protein thiol, we…”
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Characterization of adriamycin-resistant human breast cancer cells which display overexpression of a novel resistance-related membrane protein by YI-NAN CHEN, MICKLEY, L. A, SCHWARTZ, A. M, ACTON, E. M, HWANG, J, FOJO, A. T

“…Development of multidrug resistance due to overexpression of P-glycoprotein (Pgp), a cell membrane drug efflux pump, occurs commonly during in vitro selections…”
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Intrinsic drug resistance in human kidney cancer is associated with expression of a human multidrug-resistance gene by Fojo, A T, Shen, D W, Mickley, L A, Pastan, I, Gottesman, M M

“…The cloning of the cDNA for the mdr1 gene, whose expression is associated with the development of multidrug-resistance in cultured cells, has made it possible…”
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Various methods of analysis of mdr-1/P-glycoprotein in human colon cancer cell lines by Herzog, C E, Trepel, J B, Mickley, L A, Bates, S E, Fojo, A T

“…Multidrug resistance (MDR) mediated by high levels of mdr-1 (also known as PGY1)/P-glycoprotein (Pgp) has been studied in tissue culture systems; however, most…”
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Amplification of DNA Sequences in Human Multidrug-Resistant KB Carcinoma Cells by Fojo, A. T., Whang-Peng, J., Gottesman, M. M., Pastan, I.

“…Four KB carcinoma cell lines selected independently for resistance to either colchicine, adriamycin, or vinblastine were studied. All cell lines showed high…”
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Cellular control of human multidrug resistance 1 (mdr-1) gene expression in absence and presence of gene amplification in human cancer cells by KOHNO, K, TANIMURA, H, SATO, S, NAKAYAMA, Y, MAKINO, Y, WADA, M, FOJO, A. T, KUWANO, M

“…The Kst-6 cell line is a human KB carcinoma cell line that has a stably integrated chloramphenicol acetyl-transferase (CAT) reporter gene under the control of…”
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Expression of a drug resistance gene in human neuroblastoma cell lines: modulation by retinoic acid-induced differentiation by Bates, S E, Mickley, L A, Chen, Y N, Richert, N, Rudick, J, Biedler, J L, Fojo, A T

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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P-glycoprotein expression and schedule dependence of adriamycin cytotoxicity in human colon carcinoma cell lines by Lai, G M, Chen, Y N, Mickley, L A, Fojo, A T, Bates, S E

“…Four human colon cancer cell lines (SW620, LS 180, DLD-I, and HCT-15) and Adriamycin-resistant sub-lines with varying degrees of P-glycoprotein expression were…”
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Identification of mutations at DNA topoisomerase I responsible for camptothecin resistance by WANG, L.-F, TING, C.-Y, LO, C.-K, SU, J.-S, MICKLEY, L. A, FOJO, A. T, WHANG-PENG, J, HWANG, J

“…A camptothecin-resistant cell line that exhibits more than 600-fold resistance to camptothecin, designated CPT(R)-2000, was established from mutagen-treated…”
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Methods to detect P-glycoprotein-associated multidrug resistance in patients tumors : Consensus recommendations by BECK, W. T, GROGAN, T. M, BROPHY, N. A, BROXTERMAN, H. J, CHAN, H. S. L, DALTON, W. S, DIETEL, M, FOJO, A. T, GASCOYNE, R. D, HEAD, D, HOUGHTON, P. J, SRIVASTAVA, D. K, WILLMAN, C. L, LEHNERT, M, LEITH, C. P, PAIETTA, E, PAVELIC, Z. P, RIMSZA, L, RONINSON, I. B, SIKIC, B. I, TWENTYMAN, P. R, WARNKE, R, WEINSTEIN, R, CORDON-CARDO, C, PARHAM, D. M, KUTTESCH, J. F, ANDREEFF, M, BATES, S. E, BERARD, C. W, BOYETT, J. M

“…Multidrug resistance (MDR), especially that associated with overexpression of MDR1 and its product, P-glycoprotein (Pgp), is thought to play a role in the…”
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Expression of the mdr-1/P-170 Gene in Patients With Acute Lymphoblastic Leukemia by Rothenberg, Mace L., Mickley, Lyn A., Cole, Diane E., Balis, Frank M., Tsuruo, Takashi, Poplack, David G., Fojo, Antonio T.

“…Increased expression of the multidrug resistance gene (mdr-1/P-170) and the dihydrofolate reductase (DHFR) gene have been implicated in the development of in…”
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Expression of the multidrug resistance, MDR1, gene in neuroblastomas by Goldstein, L J, Fojo, A T, Ueda, K, Crist, W, Green, A, Brodeur, G, Pastan, I, Gottesman, M M

“…Metastatic neuroblastoma is a childhood malignancy that is frequently responsive to chemotherapy with doxorubicin, vincristine, and teniposide (VM26), among…”
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Mitotane enhances cytotoxicity of chemotherapy in cell lines expressing a multidrug resistance gene (mdr-1/P-glycoprotein) which is also expressed by adrenocortical carcinomas by Bates, S E, Shieh, C Y, Mickley, L A, Dichek, H L, Gazdar, A, Loriaux, D L, Fojo, A T

“…P-Glycoprotein (Pgp), product of the mdr-1 gene, is a 130- to 180-kDa plasma membrane phosphoglycoprotein which mediates multidrug resistance in cell culture…”
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Contribution of glutathione and glutathione-dependent enzymes in the reversal of adriamycin resistance in colon carcinoma cell lines by Lai, G M, Moscow, J A, Alvarez, M G, Fojo, A T, Bates, S E

“…Four human colon cancer cell lines (SW620, LS 180, DLD-I, and HCT-15) and sub-lines isolated in vitro by selection with Adriamycin were studied for reversal of…”
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Molecular targets in the National Cancer Institute drug screen by BATES, S. E, FOJO, A. T, WEINSTEIN, J. N, MYERS, T. G, ALVAREZ, M, PAULI, K. D, CHABNER, B. A

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