Search Results - "Foight, Glenna Wink"

Synthetic transcription factor engineering for cell and gene therapy by Bhatt, Bhoomi, García-Díaz, Pablo, Foight, Glenna Wink

“…Synthetic transcription factors (synTFs) that are inducible by exogenous or autonomous inputs are useful in cell and gene therapy for temporal and dosage…”
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Multi-input chemical control of protein dimerization for programming graded cellular responses by Foight, Glenna Wink, Wang, Zhizhi, Wei, Cindy T., Jr Greisen, Per, Warner, Katrina M., Cunningham-Bryant, Daniel, Park, Keunwan, Brunette, T. J., Sheffler, William, Baker, David, Maly, Dustin J.

“…Chemical and optogenetic methods for post-translationally controlling protein function have enabled modulation and engineering of cellular functions. However,…”
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Enriching Peptide Libraries for Binding Affinity and Specificity Through Computationally Directed Library Design by Foight, Glenna Wink, Chen, T Scott, Richman, Daniel, Keating, Amy E

“…Peptide reagents with high affinity or specificity for their target protein interaction partner are of utility for many important applications. Optimization of…”
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Comparison of the peptide binding preferences of three closely related TRAF paralogs: TRAF2, TRAF3, and TRAF5 by Foight, Glenna Wink, Keating, Amy E.

“…Tumor necrosis factor receptor‐associated factors (TRAFs) constitute a family of adapter proteins that act in numerous signaling pathways important in human…”
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Locating Herpesvirus Bcl-2 Homologs in the Specificity Landscape of Anti-Apoptotic Bcl-2 Proteins by Foight, Glenna Wink, Keating, Amy E.

“…Viral homologs of the anti-apoptotic Bcl-2 proteins are highly diverged from their mammalian counterparts, yet they perform overlapping functions by binding…”
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Designed BH3 Peptides with High Affinity and Specificity for Targeting Mcl‑1 in Cells by Foight, Glenna Wink, Ryan, Jeremy A, Gullá, Stefano V, Letai, Anthony, Keating, Amy E

“…Mcl-1 is overexpressed in many cancers and can confer resistance to cell-death signaling in refractory disease. Molecules that specifically inhibit Mcl-1 hold…”
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