Effects of N, N′-bisdimethyl-1,2-ethanediamine dichloride, a double-chain surfactant, on membrane-related functions in human erythrocytes

The effects of N, N′-bisdimethyl-1,2-ethanediamine dichloride (dioctyldiQAS), a double chain surfactant with two positive charges in the polar head, on the erythrocyte membrane were studied. At sublytic concentrations dioctyldiQAS protected erythrocytes against hypotonic hemolysis, induced the forma...

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Bibliographic Details
Published in:	Chemico-biological interactions Vol. 94; no. 2; pp. 147 - 155
Main Authors:	Fogt, Andrzej, Hägerstrand, Henry, Isomaa, Boris
Format:	Journal Article
Language:	English
Published:	Shannon Elsevier Ireland Ltd 01-02-1995 Elsevier Science
Subjects:	Antihemolysis Biological and medical sciences Cationic surfactant Chemical and industrial products toxicology. Toxic occupational diseases Erythrocyte membrane Erythrocyte Membrane - drug effects Erythrocyte Membrane - metabolism Erythrocytes - cytology Erythrocytes - drug effects Ethylenediamines - chemistry Ethylenediamines - pharmacology Hemolysis Hemolysis - drug effects Humans Hypotension - prevention & control Medical sciences Micelles Microscopy, Phase-Contrast Permeability alteration Phosphates - metabolism Potassium - metabolism Quaternary Ammonium Compounds - pharmacology Shape alteration Sodium-Potassium-Exchanging ATPase - drug effects Surface-Active Agents - pharmacology Toxicology Various organic compounds Hemolysis Cationic surfactant Erythrocyte membrane Shape alteration Antihemolysis Permeability alteration Human Toxicity Plasma membrane Red blood cell Hemopathy Permeability In vitro
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Summary:	The effects of N, N′-bisdimethyl-1,2-ethanediamine dichloride (dioctyldiQAS), a double chain surfactant with two positive charges in the polar head, on the erythrocyte membrane were studied. At sublytic concentrations dioctyldiQAS protected erythrocytes against hypotonic hemolysis, induced the formation of sphero-echinocytes, increased passive fluxes of potassium through the membrane, decreased the activity of the Na +-K +-pump and decreased the efflux of phosphate. The alterations in membrane-connected functions induced by dioctyldiQAS are qualitatively similar to those induced by its single-chain close analogue decyltrimethylammonium bromide. DioctyldiQAS, however, exhibited these effects at considerably lower concentrations than decyltrimethylammonium bromide. This is most likely due to a higher extent of partitioning into the membrane by dioctyldiQAS.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0009-2797 1872-7786
DOI:	10.1016/0009-2797(94)03328-6