Search Results - "Fogliatto, Gianpaolo"

WaterLOGSY as a method for primary NMR screening: practical aspects and range of applicability by Dalvit, C, Fogliatto, G, Stewart, A, Veronesi, M, Stockman, B

“…WaterLOGSY represents a powerful method for primary NMR screening in the identification of compounds interacting with macromolecules, including proteins and…”
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3-Aminopyrazole Inhibitors of CDK2/Cyclin A as Antitumor Agents. 1. Lead Finding by Pevarello, Paolo, Brasca, Maria Gabriella, Amici, Raffaella, Orsini, Paolo, Traquandi, Gabriella, Corti, Luca, Piutti, Claudia, Sansonna, Pietro, Villa, Manuela, Pierce, Betsy S, Pulici, Maurizio, Giordano, Patrizia, Martina, Katia, Fritzen, Edward L, Nugent, Richard A, Casale, Elena, Cameron, Alexander, Ciomei, Marina, Roletto, Fulvia, Isacchi, Antonella, Fogliatto, GianPaolo, Pesenti, Enrico, Pastori, Wilma, Marsiglio, Aurelio, Leach, Karen L, Clare, Paula M, Fiorentini, Francesco, Varasi, Mario, Vulpetti, Anna, Warpehoski, Martha A

“…Abnormal proliferation mediated by disruption of the normal cell cycle mechanisms is a hallmark of virtually all cancer cells. Compounds targeting complexes…”
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Crystal Structures of Anaplastic Lymphoma Kinase in Complex with ATP Competitive Inhibitors by Bossi, Roberto T, Saccardo, M. Beatrice, Ardini, Elena, Menichincheri, Maria, Rusconi, Luisa, Magnaghi, Paola, Orsini, Paolo, Avanzi, Nilla, Borgia, Andrea Lombardi, Nesi, Marcella, Bandiera, Tiziano, Fogliatto, Gianpaolo, Bertrand, Jay A

“…Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase involved in the development of several human cancers and, as a result, is a recognized target…”
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Effective immuno-targeting of the IDH1 mutation R132H in a murine model of intracranial glioma by Pellegatta, Serena, Valletta, Lorella, Corbetta, Cristina, Patanè, Monica, Zucca, Ileana, Riccardi Sirtori, Federico, Bruzzone, Maria Grazia, Fogliatto, Gianpaolo, Isacchi, Antonella, Pollo, Bianca, Finocchiaro, Gaetano

“…The R132H mutation of cytosolic isocitrate dehydrogenase (IDH1) is present in the majority of low grade gliomas.Immunotherapy in these tumors has an…”
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Establish an automated flow injection ESI-MS method for the screening of fragment based libraries: Application to Hsp90 by Riccardi Sirtori, Federico, Caronni, Dannica, Colombo, Maristella, Dalvit, Claudio, Paolucci, Mauro, Regazzoni, Luca, Visco, Carlo, Fogliatto, Gianpaolo

“…[Display omitted] ESI-MS is a well established technique for the study of biopolymers (nucleic acids, proteins) and their non covalent adducts, due to its…”
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Fragment-based hit discovery and structure-based optimization of aminotriazoloquinazolines as novel Hsp90 inhibitors by Casale, Elena, Amboldi, Nadia, Brasca, Maria Gabriella, Caronni, Dannica, Colombo, Nicoletta, Dalvit, Claudio, Felder, Eduard R., Fogliatto, Gianpaolo, Galvani, Arturo, Isacchi, Antonella, Polucci, Paolo, Riceputi, Laura, Sola, Francesco, Visco, Carlo, Zuccotto, Fabio, Casuscelli, Francesco

“…[Display omitted] In the last decade the heat shock protein 90 (Hsp90) has emerged as a major therapeutic target and many efforts have been dedicated to the…”
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Discovery and optimization of pyrrolo[1,2-a]pyrazinones leads to novel and selective inhibitors of PIM kinases by Casuscelli, Francesco, Ardini, Elena, Avanzi, Nilla, Casale, Elena, Cervi, Giovanni, D’Anello, Matteo, Donati, Daniele, Faiardi, Daniela, Ferguson, Ronald D., Fogliatto, Gianpaolo, Galvani, Arturo, Marsiglio, Aurelio, Mirizzi, Danilo G., Montemartini, Marisa, Orrenius, Christian, Papeo, Gianluca, Piutti, Claudia, Salom, Barbara, Felder, Eduard R.

“…A novel series of PIM inhibitors was derived from a combined effort in natural product-inspired library generation and screening. The novel…”
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Discovery of NMS-E973 as novel, selective and potent inhibitor of heat shock protein 90 (Hsp90) by Brasca, Maria Gabriella, Mantegani, Sergio, Amboldi, Nadia, Bindi, Simona, Caronni, Dannica, Casale, Elena, Ceccarelli, Walter, Colombo, Nicoletta, De Ponti, Anna, Donati, Daniele, Ermoli, Antonella, Fachin, Gabriele, Felder, Eduard R., Ferguson, Ronald D., Fiorelli, Claudio, Guanci, Marco, Isacchi, Antonella, Pesenti, Enrico, Polucci, Paolo, Riceputi, Laura, Sola, Francesco, Visco, Carlo, Zuccotto, Fabio, Fogliatto, Gianpaolo

“…Fragment based approach and subsequent optimization of the fragment 1 led to the identification of the heat shock protein 90 (Hsp90) inhibitor 18 (NMS-E973),…”
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NMS-E973, a Novel Synthetic Inhibitor of Hsp90 with Activity against Multiple Models of Drug Resistance to Targeted Agents, Including Intracranial Metastases by FOGLIATTO, Gianpaolo, GIANELLINI, Laura, PAOLUCCI, Mauro, POLUCCI, Paolo, RUSSO, Micaela, SOLA, Francesco, VALSASINA, Barbara, VISCO, Carlo, ZUCCOTTO, Fabio, DONATI, Daniele, FELDER, Eduard, PESENTI, Enrico, BRASCA, Maria G, GALVANI, Arturo, MANTEGANI, Sergio, ISACCHI, Antonella, CASALE, Elena, BALLINARI, Dario, CIOMEI, Marina, DEGRASSI, Anna, DE PONTI, Anna, GERMANI, Massimiliano, GUANCI, Marco

“…Recent developments of second generation Hsp90 inhibitors suggested a potential for development of this class of molecules also in tumors that have become…”
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Corrigendum to “Discovery of NMS-E973 as novel, selective and potent inhibitor of heat shock protein 90 (Hsp90)” [Bioorg. Med. Chem. 21 (2013) 7047–7063] by Brasca, Maria Gabriella, Mantegani, Sergio, Amboldi, Nadia, Bindi, Simona, Caronni, Dannica, Casale, Elena, Ceccarelli, Walter, Colombo, Nicoletta, De Ponti, Anna, Donati, Daniele, Ermoli, Antonella, Fachin, Gabriele, Felder, Eduard R., Ferguson, Ronald D., Fiorelli, Claudio, Guanci, Marco, Isacchi, Antonella, Pesenti, Enrico, Polucci, Paolo, Riceputi, Laura, Sola, Francesco, Visco, Carlo, Zuccotto, Fabio, Fogliatto, Gianpaolo

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Abstract A213: Potent anticancer activity in vitro and in vivo by NMS-E973, a novel synthetic inhibitor of HSP90 by Fogliatto, Gianpaolo, Mantegani, Sergio, Amboldi, Nadia, Ballinari, Dario, Brasca, Maria Gabriella, Caprera, Francesco, Cappella, Paolo, Casale, Elena, De Ponti, Anna, Guanci, Marco, Paolucci, Mauro, Sola, Francesco, Valsasina, Barbara, Visco, Carlo, Zuccotto, Fabio, Colotta, Francesco, Felder, Eduard, Donati, Daniele, Moll, Juergen, Galvani, Arturo, Pesenti, Enrico, Isacchi, Antonella

“…Abstract The molecular chaperone heat shock protein 90 (HSP90) is essential for the conformational maturation and stability of a variety of proteins, including…”
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3-aminopyrazole inhibitors of CDK/cyclin A as antitumor agents. 1. Lead finding by PEVARELLO, Paolo, BRASCA, Maria Gabriella, PULICI, Maurizio, GIORDANO, Patrizia, MARTINA, Katia, FRITZEN, Edward L, NUGENT, Richard A, CASALE, Elena, CAMERON, Alexander, CIOMEI, Marina, ROLETTO, Fulvia, ISACCHI, Antonella, AMICI, Raffaella, FOGLIATTO, Gianpaolo, PESENTI, Enrico, PASTORI, Wilma, MARSIGLIO, Aurelio, LEACH, Karen L, CLARE, Paula M, FIORENTINI, Francesco, VARASI, Mario, VULPETTI, Anna, WARPEHOSKI, Martha A, ORSINI, Paolo, TRAQUANDI, Gabriella, CORTI, Luca, PIUTTI, Claudia, SANSONNA, Pietro, VILLA, Manuela, PIERCE, Betsy S

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CORRECTION OF DYSLIPOPROTEINAEMIA OF CASEIN-FED RABBIT BY FCE 27677, A POTENT NOVEL ACAT INHIBITOR by CHIARI, AUGUSTO, LOVISOLO, PIERPAOLO, FOGLIATTO, GIANPAOLO, FANCELLI, DANIELE, GHISELLI, GIANCARLO

“…Rabbits fed a wheat starch casein diet develop hypercholesterolaemia characterized by the plasma elevation of low density lipoprotein (LDL) that is caused by…”
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Oxidized lipoproteins induce long-lasting inhibition of nitric oxide synthase from a murine endothelioma cell line (bEnd.4) by Fogliatto, G, Musanti, R, Pirillo, A, Ghiselli, G

“…The vascular endothelium produces nitric oxide, which has vasodilatory properties. It has been postulated that some lipoproteins may increase arterial vascular…”
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