Search Results - "Fogg, Jonathan M."
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Structural diversity of supercoiled DNA
Published in Nature communications (12-10-2015)“…By regulating access to the genetic code, DNA supercoiling strongly affects DNA metabolism. Despite its importance, however, much about supercoiled DNA…”
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Supercoiling and looping promote DNA base accessibility and coordination among distant sites
Published in Nature communications (28-09-2021)“…DNA in cells is supercoiled and constrained into loops and this supercoiling and looping influence every aspect of DNA activity. We show here that negative…”
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3
Structural basis of DNA crossover capture by Escherichia coli DNA gyrase
Published in Science (American Association for the Advancement of Science) (12-04-2024)“…DNA supercoiling must be precisely regulated by topoisomerases to prevent DNA entanglement. The interaction of type IIA DNA topoisomerases with two DNA…”
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4
DNA supercoiling-induced shapes alter minicircle hydrodynamic properties
Published in Nucleic acids research (08-05-2023)“…Abstract DNA in cells is organized in negatively supercoiled loops. The resulting torsional and bending strain allows DNA to adopt a surprisingly wide variety…”
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Suitability of double-stranded DNA as a molecular standard for the validation of analytical ultracentrifugation instruments
Published in European biophysics journal (01-07-2023)“…To address the current lack of validated molecular standards for analytical ultracentrifugation (AUC), we investigated the suitability of double-stranded DNA…”
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Influence of DNA sequence on the structure of minicircles under torsional stress
Published in Nucleic acids research (27-07-2017)“…The sequence dependence of the conformational distribution of DNA under various levels of torsional stress is an important unsolved problem. Combining theory…”
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TopA, the Sulfolobus solfataricus topoisomerase III, is a decatenase
Published in Nucleic acids research (25-01-2018)“…Abstract DNA topoisomerases are essential enzymes involved in all the DNA processes and among them, type IA topoisomerases emerged as a key actor in the…”
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Ensuring Productive Resolution by the Junction-Resolving Enzyme RuvC: Large Enhancement of the Second-Strand Cleavage Rate
Published in Biochemistry (Easton) (26-12-2000)“…RuvC is the principal junction-resolving enzyme of Escherichia coli, cleaving four-way DNA junctions created in homologous recombination. It binds with…”
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Bullied no more: when and how DNA shoves proteins around
Published in Quarterly reviews of biophysics (01-08-2012)“…The predominant protein-centric perspective in protein-DNA-binding studies assumes that the protein drives the interaction. Research focuses on protein…”
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Erratum: Structural diversity of supercoiled DNA
Published in Nature communications (29-10-2015)“…Nature Communications, 6: Article number: 8440 (2015); Published: 12 October 2015; Updated: 29 October 2015 The original version of this Article contained an…”
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11
Holliday Junction Resolution Is Modulated by Archaeal Chromatin Components in Vitro
Published in The Journal of biological chemistry (25-01-2002)“…The Holliday junction-resolving enzyme Hjc is conserved in the archaea and probably plays a role analogous to that ofEscherichia coli RuvC in the pathway of…”
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12
The complex between a four-way DNA junction and T7 endonuclease I
Published in The EMBO journal (17-03-2003)“…The junction‐resolving enzyme endonuclease I is selective for the structure of the DNA four‐way (Holliday) junction. The enzyme binds to a four‐way junction in…”
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13
Distortion of DNA junctions imposed by the binding of resolving enzymes: a fluorescence study
Published in Journal of molecular biology (02-11-2001)“…Junction-resolving enzymes are nucleases that are specific for the structure of the four-way DNA junction. The binding of RuvC of Escherichia coli and Hjc of…”
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14
Simultaneous DNA Binding and Bending by EcoRV Endonuclease Observed by Real-Time Fluorescence
Published in Biochemistry (Easton) (16-12-2003)“…The complete catalytic cycle of EcoRV endonuclease has been observed by combining fluorescence anisotropy with fluorescence resonance energy transfer (FRET)…”
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15
Yeast Resolving Enzyme CCE1 Makes Sequential Cleavages in DNA Junctions within the Lifetime of the Complex
Published in Biochemistry (Easton) (11-04-2000)“…CCE1 is a DNA junction-resolving enzyme of Saccharomyces cerevisiae. Such enzymes are required to make two symmetrically paired cleavages in order to resolve…”
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16
Supercoiling and Looping Promote DNA Base Accessibility and Coordination among Distant Sites
Published in Biophysical journal (12-02-2021)Get full text
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17
Sequence and Functional-Group Specificity for Cleavage of DNA Junctions by RuvC of Escherichia coli
Published in Biochemistry (Easton) (31-08-1999)“…RuvC is the DNA junction-resolving enzyme of Escherichia coli. While the enzyme binds to DNA junctions independently of base sequence, it exhibits considerable…”
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18
DNA Shape Shifting as a Gene Therapy Tool
Published in Biophysical journal (15-02-2019)Get full text
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