Search Results - "Fogarty, Kylie"

A High-Throughput Genetic Complementation Assay in Yeast Cells Identified Selective Inhibitors of Sphingosine Kinase 1 Not Found Using a Cell-Free Enzyme Assay by Kashem, Mohammed A, Kennedy, Charles A, Fogarty, Kylie E, Dimock, Janice R, Zhang, Yunlong, Sanville-Ross, Mary L, Skow, Donna J, Brunette, Steven R, Swantek, Jennifer L, Hummel, Heidi S, Swindle, John, Nelson, Richard M

“…Sphingosine kinase 1 (SphK1) is a lipid kinase that phosphorylates sphingosine to produce the bioactive sphingolipid, sphingosine-1-phosphate (S1P), and…”
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A high-throughput scintillation proximity assay for sphingosine-1-phosphate lyase by Kashem, Mohammed A, Wa, Chunling, Wolak, John P, Grafos, Nicholas S, Ryan, Kelli R, Sanville-Ross, Mary L, Fogarty, Kylie E, Rybina, Irina V, Shoultz, Alycia, Molinaro, Teresa, Desai, Sudha N, Rajan, Anusha, Huber, John D, Nelson, Richard M

“…The emergence of sphingosine-1-phosphate lyase (SPL) as a promising therapeutic target for inflammatory diseases has heightened interest in the identification…”
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Development of Three Orthogonal Assays Suitable for the Identification and Qualification of PIKfyve Inhibitors by Fogarty, Kylie, Kashem, Mohammed, Bauer, Andras, Bernardino, Alexandra, Brennan, Debra, Cook, Brian, Farrow, Neil, Molinaro, Teresa, Nelson, Richard

“…FYVE-type zinc finger-containing phosphoinositide kinase (PIKfyve) catalyzes the formation of phosphatidylinositol 3,5-bisphosphate (PI(3,5)P ) from…”
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Leveraging Automation toward Development of a High-Throughput Gene Expression Profiling Platform by Chen, Jing, Futran, Alan, Crithary, Austin, Li, Sha, Wolicki, Alex, Fogarty, Kylie, Baldick, Joe, Chase, Peter, Arey, Brian J, Lippy, Jonathan

“…We previously developed a panel of one-step real-time quantitative reverse transcription PCR (one-step qRT-PCR; hereafter referred to as qRT-PCR) assays to…”
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