Search Results - "Fogaca, Manoela V."

Cortical GABAergic Dysfunction in Stress and Depression: New Insights for Therapeutic Interventions by Fogaça, Manoela V, Duman, Ronald S

“…Major depressive disorder (MDD) is a debilitating illness characterized by neuroanatomical and functional alterations in limbic structures, notably the…”
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Effects of ketamine on GABAergic and glutamatergic activity in the mPFC: biphasic recruitment of GABA function in antidepressant-like responses by Fogaça, Manoela V, Daher, Fernanda, Picciotto, Marina R

“…Major depressive disorder (MDD) is associated with disruptions in glutamatergic and GABAergic activity in the medial prefrontal cortex (mPFC), leading to…”
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Ketamine rapidly reverses stress-induced impairments in GABAergic transmission in the prefrontal cortex in male rodents by Ghosal, Sriparna, Duman, Catharine H., Liu, Rong-Jian, Wu, Min, Terwilliger, Rosemarie, Girgenti, Matthew J., Wohleb, Eric, Fogaca, Manoela V., Teichman, Emily M., Hare, Brendan, Duman, Ronald S.

“…Dysfunction of medial prefrontal cortex (mPFC) in association with imbalance of inhibitory and excitatory neurotransmission has been implicated in depression…”
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Fluorinated Cannabidiol Derivatives: Enhancement of Activity in Mice Models Predictive of Anxiolytic, Antidepressant and Antipsychotic Effects by Breuer, Aviva, Haj, Christeene G, Fogaça, Manoela V, Gomes, Felipe V, Silva, Nicole Rodrigues, Pedrazzi, João Francisco, Del Bel, Elaine A, Hallak, Jaime C, Crippa, José A, Zuardi, Antonio W, Mechoulam, Raphael, Guimarães, Francisco S

“…Cannabidiol (CBD) is a major Cannabis sativa constituent, which does not cause the typical marijuana psychoactivity. However, it has been shown to be active in…”
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Neurobiology of rapid-acting antidepressants: convergent effects on GluA1-synaptic function by Duman, Ronald S., Shinohara, Ryota, Fogaça, Manoela V., Hare, Brendan

“…Efforts to develop efficacious antidepressant agents with novel mechanisms have been largely unsuccessful since the 1950’s until the discovery of ketamine, an…”
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Activity-dependent brain-derived neurotrophic factor signaling is required for the antidepressant actions of (2R,6R)-hydroxynorketamine by Fukumoto, Kenichi, Fogaça, Manoela V., Liu, Rong-Jian, Duman, Catharine, Kato, Taro, Li, Xiao-Yuan, Duman, Ronald S.

“…Ketamine, a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, produces rapid and long-lasting antidepressant effects in major depressive disorder…”
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Inhibition of GABA interneurons in the mPFC is sufficient and necessary for rapid antidepressant responses by Fogaça, Manoela V., Wu, Min, Li, Chan, Li, Xiao-Yuan, Picciotto, Marina R., Duman, Ronald S.

“…Major depressive disorder (MDD) is associated with alterations of GABAergic interneurons, notably somatostatin (Sst) as well as parvalbumin (Pvalb), in…”
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The anxiolytic effects of cannabidiol in chronically stressed mice are mediated by the endocannabinoid system: Role of neurogenesis and dendritic remodeling by Fogaça, Manoela V., Campos, Alline C., Coelho, Ludmila D., Duman, Ronald S., Guimarães, Francisco S.

“…Repeated injections of cannabidiol (CBD), the major non-psychotomimetic compound present in the Cannabis sativa plant, attenuate the anxiogenic effects induced…”
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Cannabidiol, neuroprotection and neuropsychiatric disorders by Campos, Alline C., Fogaça, Manoela V., Sonego, Andreza B., Guimarães, Francisco S.

“…[Display omitted] Cannabidiol (CBD) is a non-psychotomimetic phytocannabinoid derived from Cannabis sativa. It has possible therapeutic effects over a broad…”
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N-Methyl-D-aspartate receptor antagonist d-methadone produces rapid, mTORC1-dependent antidepressant effects by Fogaça, Manoela V, Fukumoto, Kenichi, Franklin, Tina, Liu, Rong-Jian, Duman, Catharine H, Vitolo, Ottavio V, Duman, Ronald S

“…Currently available antidepressants have a delayed onset and limited efficacy, highlighting the need for new, rapid and more efficacious agents. Ketamine, an…”
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Medial PFC AMPA receptor and BDNF signaling are required for the rapid and sustained antidepressant-like effects of 5-HT1A receptor stimulation by Fukumoto Kenichi, Fogaça Manoela V, Rong-Jian, Liu, Duman, Catharine H, Xiao-Yuan, Li, Chaki Shigeyuki, Duman, Ronald S

“…We previously reported that the serotonergic system is important for the antidepressant-like effects of ketamine, a non-competitive N-methyl-D-aspartate…”
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The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system by Campos, Alline C., Ortega, Zaira, Palazuelos, Javier, Fogaça, Manoela V., Aguiar, Daniele C., Díaz-Alonso, Javier, Ortega-Gutiérrez, Silvia, Vázquez-Villa, Henar, Moreira, Fabricio A., Guzmán, Manuel, Galve-Roperh, Ismael, Guimarães, Francisco S.

“…Cannabidiol (CBD), the main non-psychotomimetic component of the plant Cannabis sativa, exerts therapeutically promising effects on human mental health such as…”
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Cannabidiol Induces Rapid and Sustained Antidepressant-Like Effects Through Increased BDNF Signaling and Synaptogenesis in the Prefrontal Cortex by Sales, Amanda J., Fogaça, Manoela V., Sartim, Ariandra G., Pereira, Vitor S., Wegener, Gregers, Guimarães, Francisco S., Joca, Sâmia R. L.

“…Currently available antidepressants have a substantial time lag to induce therapeutic response and a relatively low efficacy. The development of drugs that…”
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Animal models of anxiety disorders and stress by Campos, Alline C, Fogaça, Manoela V, Aguiar, Daniele C, Guimarães, Francisco S

“…Anxiety and stress-related disorders are severe psychiatric conditions that affect performance in daily tasks and represent a high cost to public health. The…”
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Prefrontal cortex interneurons display dynamic sex-specific stress-induced transcriptomes by Girgenti, Matthew J., Wohleb, Eric S., Mehta, Sameet, Ghosal, Sriparna, Fogaca, Manoela V., Duman, Ronald S.

“…γ-aminobutyric acid (GABA) inhibitory interneurons play a key role in efferent and afferent control of principle neuron activity in the prefrontal cortex…”
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M1 acetylcholine receptors in somatostatin interneurons contribute to GABAergic and glutamatergic plasticity in the mPFC and antidepressant-like responses by Fogaça, Manoela V, Wu, Min, Li, Chan, Li, Xiao-Yuan, Duman, Ronald S, Picciotto, Marina R

“…Alterations in glutamatergic and GABAergic function in the medial prefrontal cortex (mPFC) are prevalent in individuals with major depressive disorder,…”
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Plastic and Neuroprotective Mechanisms Involved in the Therapeutic Effects of Cannabidiol in Psychiatric Disorders by Campos, Alline C, Fogaça, Manoela V, Scarante, Franciele F, Joca, Sâmia R L, Sales, Amanda J, Gomes, Felipe V, Sonego, Andreza B, Rodrigues, Naielly S, Galve-Roperh, Ismael, Guimarães, Francisco S

“…Beneficial effects of cannabidiol (CBD) have been described for a wide range of psychiatric disorders, including anxiety, psychosis, and depression. The…”
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The synergistic mechanism of action of Dajianzhong decoction in conjunction with ketamine in the treatment of depression by Li, Chan, Zhang, Jiping, Liu, Hanhe, Yuan, Huijie, Cai, Jianxin, Fogaça, Manoela V., Zhang, Yuan-Wei

“…Depression is a multifactorial syndrome with a variety of underlying pathological mechanisms. While ketamine, an N-methyl-D-aspartate receptor (NMDAR)…”
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The endocannabinoid and endovanilloid systems interact in the rat prelimbic medial prefrontal cortex to control anxiety-like behavior by Fogaça, Manoela V., Aguiar, Daniele C., Moreira, Fabrício A., Guimarães, Francisco S.

“…Cannabinoid receptor 1 (CB1) agonists usually induce dose-dependent biphasic effects on anxiety-related responses. Low doses induce anxiolytic-like effects,…”
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The endocannabinoid, endovanilloid and nitrergic systems could interact in the rat dorsolateral periaqueductal gray matter to control anxiety-like behaviors by Batista, Priscila A., Fogaça, Manoela V., Guimarães, Francisco S.

“…•AEA induces biphasic effects in the modulation of anxiety-like behaviors in the dlPAG.•AEA induces an anxiolytic-like effect in the dlPAG at lower doses.•The…”
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