Search Results - "Foell, Juergen"

CRISPR-Cas9 Gene Editing for Sickle Cell Disease and β-Thalassemia by Frangoul, Haydar, Altshuler, David, Cappellini, M. Domenica, Chen, Yi-Shan, Domm, Jennifer, Eustace, Brenda K, Foell, Juergen, de la Fuente, Josu, Grupp, Stephan, Handgretinger, Rupert, Ho, Tony W, Kattamis, Antonis, Kernytsky, Andrew, Lekstrom-Himes, Julie, Li, Amanda M, Locatelli, Franco, Mapara, Markus Y, de Montalembert, Mariane, Rondelli, Damiano, Sharma, Akshay, Sheth, Sujit, Soni, Sandeep, Steinberg, Martin H, Wall, Donna, Yen, Angela, Corbacioglu, Selim

“…Two patients, one with transfusion-dependent β-thalassemia and the other with sickle cell disease, received autologous CD34+ cells edited with CRISPR-Cas9…”
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Haploidentical CD3 or α/β T-cell depleted HSCT in advanced stage sickle cell disease by Foell, Juergen, Schulte, Johannes H, Pfirstinger, Beatrix, Troeger, Anja, Wolff, Daniel, Edinger, Matthias, Hofmann, Petra, Aslanidis, Charalampos, Lang, Peter, Holler, Ernst, Eggert, Angelika, Corbacioglu, Selim

“…Despite significant improvements in the supportive care, sickle cell disease (SCD) leads to significant morbidity and mortality. Allogeneic hematopoietic stem…”
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Automated production of specific T cells for treatment of refractory viral infections after allogeneic stem cell transplantation by Heinz, Amadeus T, Calkoen, Friso G J, Derbich, Alexander, Miltner, Lea, Seitz, Christian, Doering, Michaela, Braun, Christiane, Atar, Daniel, Schumm, Michael, Heubach, Florian, Arendt, Anne-Marie, Schulz, Ansgar, Schuster, Friedhelm R, Meisel, Roland, Strahm, Brigitte, Finke, Juergen, Heineking, Beatrice, Stetter, Susanne, Silling, Gerda, Stachel, Daniel, Gruhn, Bernd, Debatin, Klaus-Michael, Foell, Juergen, Schulte, Johannes H, Woessmann, Wilhelm, Mauz-Körholz, Christine, Tischer, Johanna, Feuchtinger, Tobias, Handgretinger, Rupert, Lang, Peter

“…Therapy-resistant viral reactivations contribute significantly to mortality after hematopoietic stem cell transplantation. Adoptive cellular therapy with…”
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Membrane-associated phospholipase A1 beta (LIPI) Is an Ewing tumour-associated cancer/testis antigen by Foell, Juergen L., Hesse, Manuela, Volkmer, Ines, Schmiedel, Benjamin J., Neumann, Ingo, Staege, Martin S.

“…Background Cancer/testis antigens (CTA) represent a heterogeneous group of antigens expressed nearly exclusively in tumour cells and testis. Recently, we…”
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Loss of detectability of Charcot–Leyden crystal protein transcripts in blood cells after treatment with dimethyl sulfoxide by Foell, Juergen L., Volkmer, Ines, Giersberg, Corinna, Kornhuber, Malte, Horneff, Gerd, Staege, Martin S.

“…Charcot–Leyden crystal protein (CLC) is a major secretory effector protein of eosinophils. In addition, CLC has been identified as marker for regulatory…”
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Sensitivity of Hodgkin's Lymphoma Cell Lines to the Cell Cycle Inhibitor Roscovitine by FOELL, Juergen L, MAX, Daniela, GIERSBERG, Corinna, KORHOLZ, Dieter, STAEGE, Martin S

“…Background: The prognosis of patients with Hodgkin's lymphoma (HL) has improved in recent decades. However, not all patients can be cured and the development…”
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Engagement of the CD137 (4‐1BB) costimulatory molecule inhibits and reverses the autoimmune process in collagen‐induced arthritis and establishes lasting disease resistance by Foell, Juergen L., Diez‐Mendiondo, Belkis I., Diez, Oliver H., Holzer, Ursula, Ruck, Peter, Bapat, Abhijit S., Hoffmann, Michael K., Mittler, Robert S., Dannecker, Guenther E.

“…Summary Agonistic antibodies against CD137 act as costimulators in the activation of CD8 T cells. They enhance the immune response against syngeneic tumour…”
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Effects of insulin-like growth factors and insulin-like growth factor binding protein-2 on the in vitro proliferation of peripheral blood mononuclear cells by Hettmer, Simone, Dannecker, Luciana, Foell, Juergen, Elmlinger, Martin W., Dannecker, Guenther E.

“…Increasing evidence has implicated that insulin-like growth factors (IGFs), polypeptides structurally related to proinsulin, are involved in the function and…”
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Haploidentical Aß T Cell Depleted HSCT Represents an Alternative Treatment Option in Pediatric and Adult Patients with Sickle Cell Disease (SCD) by Corbacioglu, Selim, Troeger, Anja, Kleinschmidt, Katharina, Hanafee-Alali, Tarek, Brosig, Andreas-Michael, Jakob, Marcus, Kramer, Sonja, Offner, Robert, Wolff, Daniel, Foell, Juergen

“…Background: Sickle cell disease (SCD) is the most prevalent inherited hemoglobinopathy worldwide, which is associated with considerable morbidity and early…”
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Treosulfan Based Haploidentical Αß T Cell Depleted HSCT Represents a Curative Alternative in Pediatric and Adult Patients with Transfusion Dependent Thalassaemia by Troeger, Anja, Kleinschmidt, Katharina, Hanafee-Alali, Tarek, Brosig, Andreas-Michael, Jakob, Marcus, Kramer, Sonja, Offner, Robert, Wolff, Daniel, Foell, Juergen, Corbacioglu, Selim

“…Background: Quality of life remains severely compromised in patients suffering from Transfusion Dependent Thalassemia (TDT) despite optimal supportive care…”
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Alternative donor: αß/CD19 T-cell-depleted haploidentical hematopoietic stem cell transplantation for sickle cell disease by Foell, Juergen, Kleinschmidt, Katharina, Jakob, Marcus, Troeger, Anja, Corbacioglu, Selim

“…Sickle cell disease (SCD) is an inherited disorder; despite significant improvements in supportive care, SCD continues to cause substantial morbidity,…”
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Granulocyte transfusions made with modified fluid gelatin in pediatric and adolescent patients with prolonged neutropenia by Knapp, Selina, Brosig, Andreas, Troeger, Anja, Kleinschmidt, Katharina, Offner, Robert, Corbacioglu, Selim, Burkhardt, Ralph, Foell, Juergen, Ahrens, Norbert

“…Background Granulocyte transfusions (GT) are used to treat progressive systemic or local infections in prolonged neutropenic patients with antibiotic or…”
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Haploidentical CD3 or [alpha]/[beta] T-cell depleted HSCT in advanced stage sickle cell disease by Foell, Juergen, Schulte, Johannes H, Pfirstinger, Beatrix, Troeger, Anja, Wolff, Daniel, Edinger, Matthias, Hofmann, Petra

“…Despite significant improvements in the supportive care, sickle cell disease (SCD) leads to significant morbidity and mortality. Allogeneic hematopoietic stem…”
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Feasibility of Peripheral Blood Stem Cell Collection from Heterozygoussickle Cell Trait Donors by Foell, Juergen, Morez, Morad, Troeger, Anja, Kleinschmidt, Katharina, Pfirstinger, Beatrix, Brosig, Andreas, Burkhardt, Ralph, Corbacioglu, Selim, Ahrens, Norbert

“…Introduction Allogeneic haematopoietic stem cell transplantation (HSCT) is currently the only curative treatment for sickle cell disease (SCD) offered to…”
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Irinotecan and temozolomide combined with dasatinib and rapamycin for patients with relapsed or refractory neuroblastoma: Results of the prospective randomized RIST trial by Corbacioglu, Selim, Lode, Holger N., Jakob, Marcus, Suttorp, Meinolf, Escherich, Gabriele, Gruhn, Bernd, Ellinger, Susanne, Simon, Thorsten, Lang, Peter, Rohde, Marius, Zeman, Florian, Debatin, Klaus-Michael, Beilken, Andreas, Heiss, Peter, Hellwig, Dirk, Riemenschneider, Markus, Ladenstein, Ruth Lydia, Bochennek, Konrad, Eggert, Angelika, Foell, Juergen

“…10001 Background: Relapsed or refractory neuroblastoma (r/rNB) are associated with a dismal outcome. RIST is the acronym for irinotecan and temozolomide (I/T)…”
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Feasibility of peripheral blood stem cell collection from sickle cell trait donors with an intensified G‐CSF regimen by Mohrez, Morad, Troeger, Anja, Kleinschmidt, Katharina, Alali, Tarek Hanafee, Jakob, Marcus, Brosig, Andreas, Hähnel, Viola, Kietz, Silke, Offner, Robert, Burkhardt, Ralph, Corbacioglu, Selim, Ahrens, Norbert, Foell, Juergen

“…Objectives Allogeneic hematopoietic stem cell transplantation (HSCT) is the only curative treatment for SCD and bone marrow from an HLA‐matched sibling is…”
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Bone marrow aspirations in oncological patients: experience from an in-house standard in paediatrics by Sauer, Harald, Graeber, Stefan, Lieser, Ulla, Foell, Juergen

“…Summary Background Nearly all paediatric patients require deep sedation when undergoing bone marrow aspiration (BMA). We analyzed the data from our protocols…”
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Irinotecan and temozolomide in combination with dasatinib and rapamycin versus irinotecan and temozolomide for patients with relapsed or refractory neuroblastoma (RIST-rNB-2011): a multicentre, open-label, randomised, controlled, phase 2 trial by Corbacioglu, Selim, Lode, Holger, Ellinger, Susanne, Zeman, Florian, Suttorp, Meinolf, Escherich, Gabriele, Bochennek, Konrad, Gruhn, Bernd, Lang, Peter, Rohde, Marius, Debatin, Klaus Michael, Steinbach, Daniel, Beilken, Andreas, Ladenstein, Ruth, Spachtholz, Rainer, Heiss, Peter, Hellwig, Dirk, Tröger, Anja, Koller, Michael, Menhart, Karin, Riemenschneider, Markus J, Zoubaa, Saida, Kietz, Silke, Jakob, Marcus, Sommer, Gunhild, Heise, Tilman, Hundsdörfer, Patrick, Kühnle, Ingrid, Dilloo, Dagmar, Schönberger, Stefan, Schwabe, Georg, von Luettichau, Irene, Graf, Norbert, Schlegel, Paul-Gerhardt, Frühwald, Michael, Jorch, Norbert, Paulussen, Michael, Schneider, Dominik T, Metzler, Markus, Leipold, Alfred, Nathrath, Michaela, Imschweiler, Thomas, Christiansen, Holger, Schmid, Irene, Crazzolara, Roman, Niktoreh, Naghmeh, Cario, Gunnar, Faber, Joerg, Demmert, Martin, Babor, Florian, Fröhlich, Birgit, Bielack, Stefan, Bernig, Toralf, Greil, Johann, Eggert, Angelika, Simon, Thorsten, Foell, Juergen

“…Neuroblastoma is the most common extracranial solid tumour in children. Relapsed or refractory neuroblastoma is associated with a poor outcome. We assessed the…”
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Biomodulatory Metronomic Therapy Shows Remarkable Activity in Chemorefractory Multi-System Langerhans Cell Histiocytosis by Heudobler, Daniel, Rehe, Klaus, Foell, Juergen, Corbacioglu, Selim, Hildebrandt, Gerhard, Herr, Wolfgang, Reichle, Albrecht, Vogelhuber, Martin

“…Background: Langerhans cell histiocytosis (LCH) is a disorder characterized by lesions that include CD207+ dendritic cells along with an inflammatory…”
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Stem Cell Transplantation in Advanced Stage Sickle Cell Disease with Haploidentical T-Cell Depleted PBSC Yields Comparable Outcomes to Matched Sibling Donor Bone Marrow: Results of a Pilot Study by Foell, Juergen, Schulte, Johannes, Troeger, Anja, Pfirstinger, Beatrix, Wolff, Daniel, Edinger, Matthias, Holler, Ernst, Hoffmann, Petra, Aslanidis, Charalampos, Herr, Wolfgang, Eggert, Angelika, Corbacioglu, Selim

“…Background: Sickle cell disease (SCD) is an inherited disorder with an estimate of 300,000 affected newborns per year worldwide. Despite improvements in…”
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