Search Results - "Fodor, Elfrieda"

Crossing enhanced and high fidelity SpCas9 nucleases to optimize specificity and cleavage by Kulcsár, Péter István, Tálas, András, Huszár, Krisztina, Ligeti, Zoltán, Tóth, Eszter, Weinhardt, Nóra, Fodor, Elfrieda, Welker, Ervin

“…The propensity for off-target activity of Streptococcus pyogenes Cas9 (SpCas9) has been considerably decreased by rationally engineered variants with increased…”
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The G127V variant of the prion protein interferes with dimer formation in vitro but not in cellulo by Sangeetham, Sudheer Babu, Engelke, Anna Dorothee, Fodor, Elfrieda, Krausz, Sarah Laura, Tatzelt, Jörg, Welker, Ervin

“…Scrapie prion, PrP Sc , formation is the central event of all types of transmissible spongiform encephalopathies (TSEs), while the pathway with possible…”
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CRISPR/Cas9 Mutagenesis through Introducing a Nanoparticle Complex Made of a Cationic Polymer and Nucleic Acids into Maize Protoplasts by Nagy, Bettina, Öktem, Ayşegül, Ferenc, Györgyi, Ungor, Ditta, Kalac, Aladina, Kelemen-Valkony, Ildikó, Fodor, Elfrieda, Nagy, István, Dudits, Dénes, Ayaydin, Ferhan

“…Presently, targeted gene mutagenesis attracts increasing attention both in plant research and crop improvement. In these approaches, successes are largely…”
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Cpf1 nucleases demonstrate robust activity to induce DNA modification by exploiting homology directed repair pathways in mammalian cells by Tóth, Eszter, Weinhardt, Nóra, Bencsura, Petra, Huszár, Krisztina, Kulcsár, Péter I, Tálas, András, Fodor, Elfrieda, Welker, Ervin

“…Cpf1 nucleases have recently been repurposed for site-specific genome modification. Two members of the Cpf1 family, the AsCpf1 from Acidaminococcus sp. and the…”
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Prion Protein Does Not Confer Resistance to Hippocampus-Derived Zpl Cells against the Toxic Effects of Cu2+, Mn2+, Zn2+ and Co2+ Not Supporting a General Protective Role for PrP in Transition Metal Induced Toxicity by Cingaram, Pradeep Kumar Reddy, Nyeste, Antal, Dondapati, Divya Teja, Fodor, Elfrieda, Welker, Ervin

“…The interactions of transition metals with the prion protein (PrP) are well-documented and characterized, however, there is no consensus on their role in…”
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Membrane Domain Localization and Interaction of the Prion-Family Proteins, Prion and Shadoo with Calnexin by Dondapati, Divya Teja, Cingaram, Pradeep Reddy, Ayaydin, Ferhan, Nyeste, Antal, Kanyó, Andor, Welker, Ervin, Fodor, Elfrieda

“…The cellular prion protein (PrP ) is renowned for its infectious conformational isoform PrP , capable of templating subsequent conversions of healthy PrP s and…”
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Heat stress causes spatially-distinct membrane re-modelling in K562 leukemia cells by Balogh, Gábor, Maulucci, Giuseppe, Gombos, Imre, Horváth, Ibolya, Török, Zsolt, Péter, Mária, Fodor, Elfrieda, Páli, Tibor, Benko, Sándor, Parasassi, Tiziana, De Spirito, Marco, Harwood, John L, Vígh, László

“…Cellular membranes respond rapidly to various environmental perturbations. Previously we showed that modulations in membrane fluidity achieved by heat stress…”
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A convenient method to pre-screen candidate guide RNAs for CRISPR/Cas9 gene editing by NHEJ-mediated integration of a 'self-cleaving' GFP-expression plasmid by Tálas, András, Kulcsár, Péter István, Weinhardt, Nóra, Borsy, Adrienn, Tóth, Eszter, Szebényi, Kornélia, Krausz, Sarah Laura, Huszár, Krisztina, Vida, István, Sturm, Ádám, Gordos, Bianka, Hoffmann, Orsolya Ivett, Bencsura, Petra, Nyeste, Antal, Ligeti, Zoltán, Fodor, Elfrieda, Welker, Ervin

“…The efficacies of guide RNAs (gRNAs), the short RNA molecules that bind to and determine the sequence specificity of the Streptococcus pyogenes Cas9 nuclease,…”
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Docosahexaenoic Acid-Containing Phospholipid Molecular Species in Brains of Vertebrates by Farkas, Tibor, Kitajka, Klara, Fodor, Elfrieda, Csengeri, Istvan, Lahdes, Eila, Yeo, Young K., Krasznai, Zoltan, Halver, John E.

“…The fatty acid composition of phospholipids and the contents of docosahexaenoic acid (DHA)-containing diacyl phosphatidylcholine and diacyl…”
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Role of Lipid Polymorphism in G Protein-Membrane Interactions: Nonlamellar-Prone Phospholipids and Peripheral Protein Binding to Membranes by Escriba, Pablo V., Ozaita, Andres, Ribas, Catalina, Miralles, Antonio, Fodor, Elfrieda, Farkas, Tibor, Garcia-Sevilla, Jesus A.

“…Heterotrimeric G proteins (peripheral proteins) conduct signals from membrane receptors (integral proteins) to regulatory proteins localized to various…”
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Mb- and FnCpf1 nucleases are active in mammalian cells: activities and PAM preferences of four wild-type Cpf1 nucleases and of their altered PAM specificity variants by Tóth, Eszter, Czene, Bernadett C, Kulcsár, Péter I, Krausz, Sarah L, Tálas, András, Nyeste, Antal, Varga, Éva, Huszár, Krisztina, Weinhardt, Nóra, Ligeti, Zoltán, Borsy, Adrienn É, Fodor, Elfrieda, Welker, Ervin

“…Abstract Cpf1s, the RNA-guided nucleases of the class II clustered regularly interspaced short palindromic repeats system require a short motive called…”
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Interrogating the Dimerization Interface of the Prion Protein Via Site-Specific Mutations to p-Benzoyl-L-Phenylalanine by Sangeetham, Sudheer Babu, Huszár, Krisztina, Bencsura, Petra, Nyeste, Antal, Hunyadi-Gulyás, Éva, Fodor, Elfrieda, Welker, Ervin

“…Transmissible spongiform encephalopathies are centered on the conformational transition of the prion protein from a mainly helical, monomeric structure to a…”
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Search for the Pathogenesis of the Differing Phenotype in Two Compound Heterozygote Hungarian Brothers with the Same Genotypic Triosephosphate Isomerase Deficiency by Hollan, Susan, Magocsi, Maria, Fodor, Elfrieda, Horanyi, Margit, Harsanyi, Veronika, Farkas, Tibor

“…In a Hungarian family with triosephosphate isomerase (TPI) deficiency, two compound heterozygote brothers were found with the same severe decrease in TPI…”
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Expression of the Prion Protein Family Member Shadoo Causes Drug Hypersensitivity That Is Diminished by the Coexpression of the Wild Type Prion Protein by Nyeste, Antal, Bencsura, Petra, Vida, István, Hegyi, Zoltán, Homolya, László, Fodor, Elfrieda, Welker, Ervin

“…The prion protein (PrP) seems to exert both neuroprotective and neurotoxic activities. The toxic activities are associated with the C-terminal globular parts…”
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Prion Protein Does Not Confer Resistance to Hippocampus-Derived Zpl Cells against the Toxic Effects of Cu.sup.2+, Mn.sup.2+, Zn.sup.2+ and Co.sup.2+ Not Supporting a General Protective Role for PrP in Transition Metal Induced Toxicity by Cingaram, Pradeep Kumar Reddy, Nyeste, Antal, Dondapati, Divya Teja, Fodor, Elfrieda, Welker, Ervin

“…The interactions of transition metals with the prion protein (PrP) are well-documented and characterized, however, there is no consensus on their role in…”
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Specific DNA binding by the homeodomain Nkx2.5(C56S): Detection of impaired DNA or unfolded protein by isothermal titration calorimetry by Fodor, Elfrieda, Ginsburg, Ann

“…Titrations of specific 18‐bp duplex DNA with the cardiac‐specific homeodomain Nkx2.5(C56S) have utilized an ultrasensitive isothermal titration calorimeter…”
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The Binding of DYNLL2 to Myosin Va Requires Alternatively Spliced Exon B and Stabilizes a Portion of the Myosin's Coiled-Coil Domain by Wagner, Wolfgang, Fodor, Elfrieda, Ginsburg, Ann, Hammer, John A

“…The myosin Va light chain DYNLL2 has been proposed to function as an adaptor to link the myosin to certain cargo. Here, we mapped the binding site for DYNLL2…”
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New partner proteins containing novel internal recognition motif for human glutaminase interacting protein (hGIP) by Zencir, Sevil, Banerjee, Monimoy, Dobson, Melanie J., Ayaydin, Ferhan, Fodor, Elfrieda Ayaydin, Topcu, Zeki, Mohanty, Smita

“…► We identified two new human GIP partner proteins: DTX1 and STAU1. ► DTX1 and STAU1 contain novel hGIP recognition motif. ► DTX1 and STAU1 interact with hGIP…”
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Hofmeister ions control protein dynamics by Szalontai, Balázs, Nagy, Gergely, Krumova, Sashka, Fodor, Elfrieda, Páli, Tibor, Taneva, Stefka G., Garab, Győző, Peters, Judith, Dér, András

“…Recently, we have elaborated a thermodynamic theory that could coherently interpret the diverse effects of Hofmeister ions on proteins, based on a single…”
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Stabilization of Na,K–ATPase by ionic interactions by Fodor, Elfrieda, Fedosova, Natalya U., Ferencz, Csilla, Marsh, Derek, Pali, Tibor, Esmann, Mikael

“…The effect of ions on the thermostability and unfolding of Na,K–ATPase from shark salt gland was studied and compared with that of Na,K–ATPase from pig kidney…”
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