Clinical evaluation of pre-surgical anxiety: changes in plasma levels of the anxiety peptide (diazepam binding inhibitor)

Clinical evaluation of pre-surgical anxiety: changes in plasma levels of the anxiety peptide (diazepam binding inhibitor)

The score scale of anxiety (STAI, Y, 1-2) and haematic levels of DBI (diazepam binding inhibitor) were used in 48 surgical patients for clinical evaluation of preoperative anxiety, before and after drugs for preoperative medication. After randomization, were clinically and statistically compared 6 g...

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Bibliographic Details
Published in:Minerva anestesiologica Vol. 58; no. 5; p. 245
Main Authors: Launo, C, De Grandi, R, Augeri, C, Palermo, S, Riello, R, Germi, M R, Focacci, V, Spirandelli, P, Riverso, P
Format: Journal Article
Language:Italian
Published: Italy 01-05-1992
Subjects:
Adult
Aged
Anxiety - blood
Anxiety - drug therapy
Diazepam - therapeutic use
Diazepam Binding Inhibitor
Female
Flunitrazepam - therapeutic use
Humans
Male
Middle Aged
Neuropeptides - blood
Preanesthetic Medication
Preoperative Care
Promethazine - therapeutic use
Surgical Procedures, Operative - psychology
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Summary:The score scale of anxiety (STAI, Y, 1-2) and haematic levels of DBI (diazepam binding inhibitor) were used in 48 surgical patients for clinical evaluation of preoperative anxiety, before and after drugs for preoperative medication. After randomization, were clinically and statistically compared 6 groups according to premedicant drugs (diazepam 0.3 mg/kg; flunitrazepam 0.03 mg/kg; saline; prometazine 0.7 mg/kg); before and after preoperative medication were evaluated the anxiety relief with the score scale, haematic levels of DBI and haemodynamics (systolic and diastolic AP and HR). The results show that DBI can objectively measure the anxiety relief, that not are correlate haematic levels of DBI and score scale, that the best benzodiazepines are diazepam (0.3) and flunitrazepam (0.015) and that the prometazine might give anxiety relief for 5-HT antagonist action. Even if there are limits to study (scanty cases, are missing the range and the brain values of DBI and blood test of DBI is slow method) may be useful the use of score scale and haematic levels of DBI in clinical evaluation of preoperative anxiety relief.
ISSN:0375-9393