Search Results - "Flynn, T G"

A new nomenclature for the aldo-keto reductase superfamily by Jez, Joseph M, Flynn, T.Geoffrey, Penning, Trevor M

“…The aldo-keto reductases (AKRs) represent a growing oxidoreductase superfamily. Forty proteins have been identified and characterized as AKRs, and an…”
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Salt-sensitive hypertension in ANP knockout mice: potential role of abnormal plasma renin activity by Melo, L G, Veress, A T, Chong, C K, Pang, S C, Flynn, T G, Sonnenberg, H

“…Atrial natriuretic peptide (ANP), a peptide hormone produced by the heart, exerts a chronic hypotensive effect. Knockout mice with a homozygous disruption of…”
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Enhancement of recovery from psychiatric illness by methylfolate by Godfrey, P S, Toone, B K, Carney, M W, Flynn, T G, Bottiglieri, T, Laundy, M, Chanarin, I, Reynolds, E H

“…41 (33%) of 123 patients with acute psychiatric disorders (DSM III diagnosis of major depression or schizophrenia) had borderline or definite folate deficiency…”
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Studies on pig muscle aldose reductase. Kinetic mechanism and evidence for a slow conformational change upon coenzyme binding by KUBISESKI, T. J, HYNDMAN, D. J, MORJANA, N. A, FLYNN, T. G

“…Steady state kinetic analysis at pH 7.0 of the reduction of DL-glyceraldehyde by pig muscle aldose reductase showed that the enzyme follows a sequential…”
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Chronic hypertension in ANP knockout mice: contribution of peripheral resistance by Melo, L.G, Veress, A.T, Ackermann, U, Pang, S.C, Flynn, T.G, Sonnenberg, H

“…Atrial Natriuretic Peptide (ANP) exerts a chronic hypotensive effect which is mediated by a reduction in total peripheral resistance (TPR). Mice with a…”
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Expression of B-type natriuretic peptide in atrial natriuretic peptide gene disrupted mice by Tse, M Y, Watson, J D, Sarda, I R, Flynn, T G, Pang, S C

“…Atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) are two hormones produced and secreted by the heart to control blood pressure, body fluid…”
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Cloning and expression of human aldose reductase by NISHIMURA, C, MATSUURA, Y, KOKAI, Y, AKERA, T, CARPER, D, MORJANA, N, LYONS, C, FLYNN, T. G

“…The complete amino acid sequence of human retina and muscle aldose reductase was determined by nucleotide analysis of cDNA clones isolated using synthetic…”
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The aldo-keto reductases and their role in cancer by Hyndman, D, Flynn, T G

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The biochemistry and molecular biology of atrial natriuretic factor by Flynn, T G, Davies, P L

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Aldose reductase from human psoas muscle. Purification, substrate specificity, immunological characterization, and effect of drugs and inhibitors by Morjana, N A, Flynn, T G

“…Aldose reductase (ALR2) has been purified to homogeneity from human psoas muscle. From sodium dodecyl sulfate-polyacrylamide electrophoresis the enzyme is…”
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Past and current perspectives on the natriuretic peptides by Flynn, T G

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Determination of the 1-ethyl-3-[(3-dimethylamino)propyl]-carbodiimide- induced cross-link between the beta and epsilon subunits of Escherichia coli F1-ATPase by GARRY DALLMANN, H, GEOFFREY FLYNN, T, DUNN, S. D

“…The zero-length cross-link between the inhibitory epsilon subunit and one of three catalytic beta subunits of Escherichia coli F1-ATPase (alpha 3 beta 3 gamma…”
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The crystal structure of an aldehyde reductase Y50F mutant-NADP complex and its implications for substrate binding by Ye, Q., Hyndman, D., Green, N.C., Li, L., Jia, Z., Flynn, T.G.

“…In order to understand more fully the structural features of aldo-keto reductases (AKRs) that determine their substrate specificities it would be desirable to…”
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Photoaffinity labeling of atrial natriuretic factor receptors of rat kidney cortex plasma membranes by Yip, C C, Laing, L P, Flynn, T G

“…Synthetic rat atrial natriuretic factor (ANF) was derivatized with the N-hydroxysuccinimide ester of [125I]iodoazidosalicylic acid to yield a radioactive…”
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Secretion of atrial natriuretic peptide and vasopressin by small cell lung cancer by Campling, B G, Sarda, I R, Baer, K A, Pang, S C, Baker, H M, Lofters, W S, Flynn, T G

“…Hyponatremia in patients with small cell lung cancer (SCLC) is a common clinical problem usually attributed to tumor secretion of arginine vasopressin (AVP)…”
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Aldose reductase from human psoas muscle. Affinity labeling of an active site lysine by pyridoxal 5'-phosphate and pyridoxal 5'-diphospho-5'-adenosine by Morjana, N A, Lyons, C, Flynn, T G

“…The reaction of aldose reductase from human psoas muscle with either pyridoxal 5'-phosphate (PLP) or pyridoxal 5'-diphospho-5'-adenosine (PLP-AMP) results in a…”
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Studies on pig aldose reductase. Identification of an essential arginine in the primary and tertiary structure of the enzyme by KUBISESKI, T. J, GREEN, N. C, BORHANI, D. W, FLYNN, T. G

“…Reaction of pig muscle aldose reductase with phenylglyoxal resulted in the chemical modification of 2 arginine residues with accompanying loss of catalytic…”
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Alignment of Rat Cardionatrin Sequences with the Preprocardionatrin Sequence from Complementary DNA by Flynn, T. G., Davies, P. L., Kennedy, B. P., De Bold, M. L., De Bold, A. J.

“…Mammalian atria contain peptides that promote the excretion of salt and water from the kidney. When rat atrial tissue is extracted under conditions known to…”
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ANP secretion from small cell lung cancer cell lines: a potential model of ANP release by Wigle, D A, Campling, B G, Sarda, I R, Shin, S H, Watson, J D, Frater, Y, Flynn, T G, Pang, S C

“…Although atrial distension is widely accepted as the primary stimulus for atrial natriuretic peptide (ANP) release, a number of agonists are also known to…”
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Genetic Decreases in Atrial Natriuretic Peptide and Salt-Sensitive Hypertension by Simon W. M. John, Krege, John H., Oliver, Paula M., Hagaman, John R., Hodgin, Jeffrey B., Pang, Stephen C., Flynn, T. Geoffrey, Smithies, Oliver

“…To determine if defects in the atrial natriuretic peptide (ANP) system can cause hypertension, mice were generated with a disruption of the proANP gene…”
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