Search Results - "Flynn, Noah"

Machine learning liver-injuring drug interactions with non-steroidal anti-inflammatory drugs (NSAIDs) from a retrospective electronic health record (EHR) cohort by Datta, Arghya, Flynn, Noah R., Barnette, Dustyn A., Woeltje, Keith F., Miller, Grover P., Swamidass, S. Joshua

“…Drug-drug interactions account for up to 30% of adverse drug reactions. Increasing prevalence of electronic health records (EHRs) offers a unique opportunity…”
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Message Passing Neural Networks Improve Prediction of Metabolite Authenticity by Flynn, Noah R., Swamidass, S. Joshua

“…Cytochrome P450 enzymes aid in the elimination of a preponderance of small molecule drugs, but can generate reactive metabolites that may adversely react with…”
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XenoNet: Inference and Likelihood of Intermediate Metabolite Formation by Flynn, Noah R, Dang, Na Le, Ward, Michael D, Swamidass, S. Joshua

“…Drug metabolism is a common cause of adverse drug reactions. Drug molecules can be metabolized into reactive metabolites, which can conjugate to biomolecules,…”
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Editorial: Advancements in computational studies of drug toxicity by Flynn, Noah R, Miller, Grover P, Swamidass, S Joshua

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Metabolic Forest: Predicting the Diverse Structures of Drug Metabolites by Hughes, Tyler B, Dang, Na Le, Kumar, Ayush, Flynn, Noah R, Swamidass, S. Joshua

“…Adverse drug metabolism often severely impacts patient morbidity and mortality. Unfortunately, drug metabolism experimental assays are costly, inefficient, and…”
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Significance of Multiple Bioactivation Pathways for Meclofenamate as Revealed through Modeling and Reaction Kinetics by Schleiff, Mary Alexandra, Flynn, Noah R, Payakachat, Sasin, Schleiff, Benjamin Mark, Pinson, Anna O, Province, Dennis W, Swamidass, S Joshua, Boysen, Gunnar, Miller, Grover P

“…Meclofenamate is a nonsteroidal anti-inflammatory drug used in the treatment of mild-to-moderate pain yet poses a rare risk of hepatotoxicity through an…”
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CYP2C19 and 3A4 Dominate Metabolic Clearance and Bioactivation of Terbinafine Based on Computational and Experimental Approaches by Davis, Mary A, Barnette, Dustyn A, Flynn, Noah R, Pidugu, Anirudh S, Swamidass, S. Joshua, Boysen, Gunnar, Miller, Grover P

“…Lamisil (terbinafine) is an effective, widely prescribed antifungal drug that causes rare idiosyncratic hepatotoxicity. The proposed toxic mechanism involves a…”
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Discovery of Novel Reductive Elimination Pathway for 10-Hydroxywarfarin by Pouncey, Dakota L, Barnette, Dustyn A, Sinnott, Riley W, Phillips, Sarah J, Flynn, Noah R, Hendrickson, Howard P, Swamidass, S Joshua, Miller, Grover P

“…Coumadin (R/S-warfarin) anticoagulant therapy is highly efficacious in preventing the formation of blood clots; however, significant inter-individual…”
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Bioactivation of Isoxazole-Containing Bromodomain and Extra-Terminal Domain (BET) Inhibitors by Flynn, Noah R., Ward, Michael D., Schleiff, Mary A., Laurin, Corentine M. C., Farmer, Rohit, Conway, Stuart J., Boysen, Gunnar, Swamidass, S. Joshua, Miller, Grover P.

“…The 3,5-dimethylisoxazole motif has become a useful and popular acetyl-lysine mimic employed in isoxazole-containing bromodomain and extra-terminal (BET)…”
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Cal-Net: Jointly Learning Classification and Calibration On Imbalanced Binary Classification Tasks by Datta, Arghya, Flynn, Noah R., Swamidass, S. Joshua

“…Datasets in critical domains are often class imbalanced, with a minority class far rarer than the majority class, and classification models face challenges to…”
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Novel Bioactivation of Isoxazole‐containing Bromodomain and Extra Terminal Domain (BET) Inhibitors by Miller, Grover, Schleiff, Mary, Flynn, Noah, Ward, Michael, Laurin, Coretine, Conway, Stuart, Swamidass, S.

“…Bromodomain and extra‐terminal (BET) inhibitors comprise a growing class of anti‐cancer agents. New generations of BET inhibitors seek to capitalize on the…”
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Modeling the Bioactivation and Subsequent Reactivity of Drugs by Hughes, Tyler B, Flynn, Noah, Dang, Na Le, Swamidass, S. Joshua

“…Electrophilically reactive drug metabolites are implicated in many adverse drug reactions. In this mechanismtermed bioactivationmetabolic enzymes convert…”
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Meloxicam methyl group determines enzyme specificity for thiazole bioactivation compared to sudoxicam by Barnette, Dustyn A., Schleiff, Mary A., Datta, Arghya, Flynn, Noah, Swamidass, S. Joshua, Miller, Grover P.

“…[Display omitted] •Quantitative kinetics revealed enzyme roles in meloxicam/sudoxicam metabolism.•Thiazole methyl substituent alters enzyme specificity for…”
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Computational Approaches for Screening Drugs for Bioactivation, Reactive Metabolite Formation, and Toxicity by Flynn, Noah

“…Cytochrome P450 enzymes aid in the elimination of a preponderance of small molecule drugs, but can generate reactive metabolites that may adversely conjugate…”
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Machine learning liver-injuring drug interactions with non-steroidal anti-inflammatory drugs by Datta, Arghya, Flynn, Noah R, Barnette, Dustyn A, Woeltje, Keith F, Miller, Grover P, Swamidass, S. Joshua

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Machine learning liver-injuring drug interactions with non-steroidal anti-inflammatory drugs cohort by Datta, Arghya, Flynn, Noah R, Barnette, Dustyn A, Woeltje, Keith F, Miller, Grover P, Swamidass, S. Joshua

“…Drug-drug interactions account for up to 30% of adverse drug reactions. Increasing prevalence of electronic health records (EHRs) offers a unique opportunity…”
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Dual mechanisms suppress meloxicam bioactivation relative to sudoxicam by Barnette, Dustyn A., Schleiff, Mary A., Osborn, Laura R., Flynn, Noah, Matlock, Matthew, Swamidass, S. Joshua, Miller, Grover P.

“…[Display omitted] •Electron density increased modeled epoxidations but depended on substituent types.•Novel kinetics showed impact of thiazole methyl on…”
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Comprehensive kinetic and modeling analyses revealed CYP2C9 and 3A4 determine terbinafine metabolic clearance and bioactivation by Barnette, Dustyn A., Davis, Mary A., Flynn, Noah, Pidugu, Anirudh S., Swamidass, S. Joshua, Miller, Grover P.

“…[Display omitted] Terbinafine N-dealkylation pathways result in formation of 6,6-dimethyl-2-hepten-4-ynal (TBF-A), a reactive allylic aldehyde, that may…”
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SEACrowd: A Multilingual Multimodal Data Hub and Benchmark Suite for Southeast Asian Languages by Lovenia, Holy, Mahendra, Rahmad, Akbar, Salsabil Maulana, Miranda, Lester James V, Santoso, Jennifer, Aco, Elyanah, Fadhilah, Akhdan, Mansurov, Jonibek, Imperial, Joseph Marvin, Kampman, Onno P, Moniz, Joel Ruben Antony, Habibi, Muhammad Ravi Shulthan, Hudi, Frederikus, Montalan, Railey, Ignatius, Ryan, Lopo, Joanito Agili, Nixon, William, Karlsson, Börje F, Jaya, James, Diandaru, Ryandito, Gao, Yuze, Amadeus, Patrick, Wang, Bin, Cruz, Jan Christian Blaise, Whitehouse, Chenxi, Parmonangan, Ivan Halim, Khelli, Maria, Zhang, Wenyu, Susanto, Lucky, Ryanda, Reynard Adha, Hermawan, Sonny Lazuardi, Velasco, Dan John, Kautsar, Muhammad Dehan Al, Hendria, Willy Fitra, Moslem, Yasmin, Flynn, Noah, Adilazuarda, Muhammad Farid, Li, Haochen, Lee, Johanes, Damanhuri, R, Sun, Shuo, Qorib, Muhammad Reza, Djanibekov, Amirbek, Leong, Wei Qi, Do, Quyet V, Muennighoff, Niklas, Pansuwan, Tanrada, Putra, Ilham Firdausi, Xu, Yan, Tai, Ngee Chia, Purwarianti, Ayu, Ruder, Sebastian, Tjhi, William, Limkonchotiwat, Peerat, Aji, Alham Fikri, Keh, Sedrick, Winata, Genta Indra, Zhang, Ruochen, Koto, Fajri, Yong, Zheng-Xin, Cahyawijaya, Samuel

“…Southeast Asia (SEA) is a region rich in linguistic diversity and cultural variety, with over 1,300 indigenous languages and a population of 671 million…”
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