Search Results - "Flynn, James M"

Analysis of individual cells identifies cell‐to‐cell variability following induction of cellular senescence by Wiley, Christopher D., Flynn, James M., Morrissey, Christapher, Lebofsky, Ronald, Shuga, Joe, Dong, Xiao, Unger, Marc A., Vijg, Jan, Melov, Simon, Campisi, Judith

“…Summary Senescent cells play important roles in both physiological and pathological processes, including cancer and aging. In all cases, however, senescent…”
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Late‐life rapamycin treatment reverses age‐related heart dysfunction by Flynn, James M., O'Leary, Monique N., Zambataro, Christopher A., Academia, Emmeline C., Presley, Michael P., Garrett, Brittany J., Zykovich, Artem, Mooney, Sean D., Strong, Randy, Rosen, Clifford J., Kapahi, Pankaj, Nelson, Michael D., Kennedy, Brian K., Melov, Simon

“…Summary Rapamycin has been shown to extend lifespan in numerous model organisms including mice, with the most dramatic longevity effects reported in females…”
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Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin by Velarde, Michael C, Flynn, James M, Day, Nicholas U, Melov, Simon, Campisi, Judith

“…Cellular senescence arrests the proliferation of mammalian cells at risk for neoplastic transformation, and is also associated with aging. However, the factors…”
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Acute Kidney Recovery in Patients Who Underwent Transcatheter Versus Surgical Aortic Valve Replacement (from the Northern New England Cardiovascular Disease Study Group) by Lahoud, Rony, Butzel, David W., Parsee, Anahita, Huang, Yi-Ling, Solomon, Richard J., DeVries, James T., Flynn, James M., Iribarne, Alexander, Lee, Peter Ver, Ross, Cathy S., Malenka, David J., Dauerman, Harold L.

“…Acute kidney recovery (AKR) is a recently described phenomenon observed after transcatheter aortic valve replacement (TAVR) and is more frequent than acute…”
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SOD2 in mitochondrial dysfunction and neurodegeneration by Flynn, James M., Melov, Simon

“…The brain is a highly metabolically active tissue that critically relies on oxidative phosphorylation as a means for maintaining energy. One result of this…”
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Impaired spare respiratory capacity in cortical synaptosomes from Sod2 null mice by Flynn, James M., Choi, Sung W., Day, Nicholas U., Gerencser, Akos A., Hubbard, Alan, Melov, Simon

“…Presynaptic nerve terminals require high levels of ATP for the maintenance of synaptic function. Failure of synaptic mitochondria to generate adequate ATP has…”
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Retraction Note to: Exercise-induced mitochondrial p53 repairs mtDNA mutations in mutator mice by Safdar, Adeel, Khrapko, Konstantin, Flynn, James M, Saleem, Ayesha, De Lisio, Michael, Johnston, Adam P W, Kratysberg, Yevgenya, Samjoo, Imtiaz A, Kitaoka, Yu, Ogborn, Daniel I, Little, Jonathan P, Raha, Sandeep, Parise, Gianni, Akhtar, Mahmood, Hettinga, Bart P, Rowe, Glenn C, Arany, Zoltan, Prolla, Tomas A, Tarnopolsky, Mark A

“…An amendment to this paper has been published and can be accessed via the original article…”
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Expanded Contraceptive Access Linked To Increase In College Completion Among Women In Colorado by Yeatman, Sara, Flynn, James M, Stevenson, Amanda, Genadek, Katie, Mollborn, Stefanie, Menken, Jane

“…Public subsidies for contraception are often justified by assertions regarding their benefits for women's lives, yet there is limited contemporary evidence…”
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Adrenergic Receptors in Individual Ventricular Myocytes: The Beta-1 and Alpha-1B Are in All Cells, the Alpha-1A Is in a Subpopulation, and the Beta-2 and Beta-3 Are Mostly Absent by Myagmar, Bat-Erdene, Flynn, James M, Cowley, Patrick M, Swigart, Philip M, Montgomery, Megan D, Thai, Kevin, Nair, Divya, Gupta, Rumita, Deng, David X, Hosoda, Chihiro, Melov, Simon, Baker, Anthony J, Simpson, Paul C

“…RATIONALE:It is unknown whether every ventricular myocyte expresses all 5 of the cardiac adrenergic receptors (ARs), β1, β2, β3, α1A, and α1B. The β1 and β2…”
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Genome‐wide DNA methylation changes with age in disease‐free human skeletal muscle by Zykovich, Artem, Hubbard, Alan, Flynn, James M., Tarnopolsky, Mark, Fraga, Mario F., Kerksick, Chad, Ogborn, Dan, MacNeil, Lauren, Mooney, Sean D., Melov, Simon

“…Summary A decline in skeletal muscle mass and function with aging is well recognized, but remains poorly characterized at the molecular level. Here, we report…”
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Decade Long Temporal Trends in Revascularization for Patients With Diabetes Mellitus (From the Northern New England Cardiovascular Disease Study Group) by Denkmann, Jan H., Malenka, David J., Ramkumar, Niveditta, Ross, Cathy S., Young, Michael N., Vasaiwal, Samip, Flynn, James M., Dauerman, Harold L.

“…The FREEDOM trial demonstrated superiority of coronary artery bypass grafting (CABG) for patients with diabetes mellitus (DM) and multivessel coronary artery…”
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Concordance of Guideline-Based Risk Stratification and Selection of Patients for Transcatheter Aortic Valve Implantation or Surgical Replacement by Sharma, Toishi, Tapales, Althea J.D., Ross, Cathy S., Malenka, David J., Flynn, James M., Ferguson, Michael, Young, Michael N., Vasaiwala, Samip, Kramer, Robert S., Iribarne, Alexander, Dauerman, Harold L.

“…The 2020 American Health Association/American College of Cardiology valve guidelines recommend surgical aortic valve replacement (SAVR) for symptomatic…”
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Recovery of Kidney Dysfunction After Transcatheter Aortic Valve Implantation (from the Northern New England Cardiovascular Disease Study Group) by Azarbal, Amir, Malenka, David J., Huang, Yi-Ling, Ross, Cathy S., Solomon, Richard J., DeVries, James T., Flynn, James M., Butzel, David, McKay, Matthew, Dauerman, Harold L.

“…Acute Kidney Recovery (AKR) is a potential benefit of transcatheter aortic valve implantation (TAVI). We determined the incidence and predictors of AKR in a…”
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Multicenter experience with valve‐in‐valve transcatheter aortic valve replacement compared with primary, native valve transcatheter aortic valve replacement by Robich, Michael P., Iribarne, Alexander, Butzel, David, DiScipio, Anthony W., Dauerman, Harold L., Leavitt, Bruce J., DeSimone, Joseph P., Coylewright, Megan, Flynn, James M., Westbrook, Benjamin M., Ver Lee, Peter N., Zaky, Mina, Quinn, Reed, Malenka, David J.

“…Background Valve‐in‐valve (ViV) transcatheter aortic valve replacement (TAVR) offers an alternative to reoperative surgical aortic valve replacement. The…”
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Exercise-induced mitochondrial p53 repairs mtDNA mutations in mutator mice by Safdar, Adeel, Khrapko, Konstantin, Flynn, James M, Saleem, Ayesha, De Lisio, Michael, Johnston, Adam P W, Kratysberg, Yevgenya, Samjoo, Imtiaz A, Kitaoka, Yu, Ogborn, Daniel I, Little, Jonathan P, Raha, Sandeep, Parise, Gianni, Akhtar, Mahmood, Hettinga, Bart P, Rowe, Glenn C, Arany, Zoltan, Prolla, Tomas A, Tarnopolsky, Mark A

“…Human genetic disorders and transgenic mouse models have shown that mitochondrial DNA (mtDNA) mutations and telomere dysfunction instigate the aging process…”
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Single cell gene expression profiling of cortical osteoblast lineage cells by Flynn, James M, Spusta, Steven C, Rosen, Clifford J, Melov, Simon

“…Abstract In tissues with complex architectures such as bone, it is often difficult to purify and characterize specific cell types via molecular profiling…”
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No consistent bioenergetic defects in presynaptic nerve terminals isolated from mouse models of Alzheimer's disease by Choi, Sung W, Gerencser, Akos A, Ng, Ryan, Flynn, James M, Melov, Simon, Danielson, Steven R, Gibson, Bradford W, Nicholls, David G, Bredesen, Dale E, Brand, Martin D

“…Depressed cortical energy supply and impaired synaptic function are predominant associations of Alzheimer's disease (AD). To test the hypothesis that…”
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Proteogenomics of synaptosomal mitochondrial oxidative stress by Flynn, James M., Czerwieniec, Gregg A., Choi, Sung W., Day, Nicholas U., Gibson, Bradford W., Hubbard, Alan, Melov, Simon

“…Oxidative stress is frequently implicated in the pathology of neurodegenerative disease. The chief source of this stress is mitochondrial respiration, via the…”
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Long-term calorie restriction in humans is not associated with indices of delayed immunologic aging: A descriptive study by Tomiyama, A. Janet, Milush, Jeffrey M., Lin, Jue, Flynn, James M., Kapahi, Pankaj, Verdin, Eric, Sinclair, Elizabeth, Melov, Simon, Epel, Elissa S.

“…BACKGROUND: Delayed immunologic aging is purported to be a major mechanism through which calorie restriction (CR) exerts its anti-aging effects in non-human…”
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Single cell transcriptional profiling of adult mouse cardiomyocytes by Flynn, James M, Santana, Luis F, Melov, Simon

“…While numerous studies have examined gene expression changes from homogenates of heart tissue, this prevents studying the inherent stochastic variation between…”
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