Search Results - "Flynn, E Megan"

A Subset of Human Bromodomains Recognizes Butyryllysine and Crotonyllysine Histone Peptide Modifications by Flynn, E. Megan, Huang, Oscar W., Poy, Florence, Oppikofer, Mariano, Bellon, Steve F., Tang, Yong, Cochran, Andrea G.

“…Bromodomains are epigenetic readers that are recruited to acetyllysine residues in histone tails. Recent studies have identified non-acetyl acyllysine…”
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Enhancer Activity Requires CBP/P300 Bromodomain-Dependent Histone H3K27 Acetylation by Raisner, Ryan, Kharbanda, Samir, Jin, Lingyan, Jeng, Edwin, Chan, Emily, Merchant, Mark, Haverty, Peter M., Bainer, Russell, Cheung, Tommy, Arnott, David, Flynn, E. Megan, Romero, F. Anthony, Magnuson, Steven, Gascoigne, Karen E.

“…Acetylation of histone H3 at lysine 27 is a well-defined marker of enhancer activity. However, the functional impact of this modification at enhancers is…”
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An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells by Vinogradova, Maia, Gehling, Victor S, Gustafson, Amy, Arora, Shilpi, Tindell, Charles A, Wilson, Catherine, Williamson, Kaylyn E, Guler, Gulfem D, Gangurde, Pranoti, Manieri, Wanda, Busby, Jennifer, Flynn, E Megan, Lan, Fei, Kim, Hyo-jin, Odate, Shobu, Cochran, Andrea G, Liu, Yichin, Wongchenko, Matthew, Yang, Yibin, Cheung, Tommy K, Maile, Tobias M, Lau, Ted, Costa, Michael, Hegde, Ganapati V, Jackson, Erica, Pitti, Robert, Arnott, David, Bailey, Christopher, Bellon, Steve, Cummings, Richard T, Albrecht, Brian K, Harmange, Jean-Christophe, Kiefer, James R, Trojer, Patrick, Classon, Marie

“…KDM5 histone demethylases promote the survival of drug-tolerant persister (DTP) cells in certain cancers. CPI-455, a chemical probe specific for KDM5, elevates…”
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Social Media and Total Joint Arthroplasty: An Analysis of Patient Utilization on Instagram by Ramkumar, Prem N., MD MBA, Navarro, Sergio M., BS BS, Haeberle, Heather S., BA, Chughtai, Morad, MD, Flynn, Megan E., MD, Mont, Michael A., MD

“…Abstract Objectives The purpose of this observational study was to investigate and analyze the nature of the shared content of lower extremity total joint…”
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Targeted Nitric Oxide Delivery by Supramolecular Nanofibers for the Prevention of Restenosis After Arterial Injury by Bahnson, Edward S M, Kassam, Hussein A, Moyer, Tyson J, Jiang, Wulin, Morgan, Courtney E, Vercammen, Janet M, Jiang, Qun, Flynn, Megan E, Stupp, Samuel I, Kibbe, Melina R

“…Cardiovascular interventions continue to fail as a result of arterial restenosis secondary to neointimal hyperplasia. We sought to develop and evaluate a…”
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Non-canonical reader modules of BAZ1A promote recovery from DNA damage by Oppikofer, Mariano, Sagolla, Meredith, Haley, Benjamin, Zhang, Hui-Min, Kummerfeld, Sarah K., Sudhamsu, Jawahar, Flynn, E. Megan, Bai, Tianyi, Zhang, Jennifer, Ciferri, Claudio, Cochran, Andrea G.

“…Members of the ISWI family of chromatin remodelers mobilize nucleosomes to control DNA accessibility and, in some cases, are required for recovery from DNA…”
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Inhibition of bromodomain-containing protein 9 for the prevention of epigenetically-defined drug resistance by Crawford, Terry D., Vartanian, Steffan, Côté, Alexandre, Bellon, Steve, Duplessis, Martin, Flynn, E. Megan, Hewitt, Michael, Huang, Hon-Ren, Kiefer, James R., Murray, Jeremy, Nasveschuk, Christopher G., Pardo, Eneida, Romero, F. Anthony, Sandy, Peter, Tang, Yong, Taylor, Alexander M., Tsui, Vickie, Wang, Jian, Wang, Shumei, Zawadzke, Laura, Albrecht, Brian K., Magnuson, Steven R., Cochran, Andrea G., Stokoe, David

“…[Display omitted] Bromodomain-containing protein 9 (BRD9), an epigenetic “reader” of acetylated lysines on post-translationally modified histone proteins, is…”
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Dynamic Active-Site Protection by the M. tuberculosis Protein Tyrosine Phosphatase PtpB Lid Domain by Flynn, E. Megan, Hanson, Jeffrey A, Alber, Tom, Yang, Haw

“…The Mycobacterium tuberculosis protein tyrosine phosphatase PtpB shows resistance to the oxidative conditions that prevail within an infected host macrophage,…”
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Establishment of a rat and guinea pig aortic interposition graft model reveals model specific patterns of intimal hyperplasia by Gregory, Elaine K., MD, Vercammen, Janet M., AAS, Flynn, Megan E., MS, Kibbe, Melina R., MD

“…Objective Although the aortic interposition bypass model has been widely used to evaluate biomaterials for bypass grafting, there is no comprehensive…”
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Microparticle levels after arterial injury and NO therapy in diabetes by Wang, Zheng, BA, Emond, Zachary M., MD, Flynn, Megan E., MS, Swaminathan, Suchitra, PhD, Kibbe, Melina R., MD

“…Abstract Background Little is known about how arterial injury, nitric oxide (NO), or the diabetic milieu impact microparticle (MP) levels in the vasculature…”
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Nitric oxide differentially affects proteasome activator 28 after arterial injury in type 1 and type 2 diabetic rats by Tsihlis, Nick D., PhD, Rodriguez, Monica P., MD, Jiang, Qun, MD, Schwartz, Amanda, BA, Flynn, Megan E., MS, Vercammen, Janet M., AAS, Kibbe, Melina R., MD

“…Abstract Background Diabetic patients display aggressive restenosis after vascular interventions, likely because of proproliferative influences of…”
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Mechanism of multiple lysine methylation by the SET domain enzyme Rubisco LSMT by Hurley, James H, Trievel, Raymond C, Flynn, E Megan, Houtz, Robert L

“…SET domain protein methyltransferases catalyze the transfer of methyl groups from the cofactor S-adenosylmethionine (AdoMet) to specific lysine residues of…”
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Trifluoroacetyl Lysine as a Bromodomain Binding Mimic of Lysine Acetylation by Miller, Gregory M., Flynn, E. Megan, Tom, Jeffrey, Song, Aimin, Cochran, Andrea G.

“…Genetic code expansion has proven invaluable to the elucidation of functions of defined protein modifications through the site-specific incorporation of…”
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Diving into the Water: Inducible Binding Conformations for BRD4, TAF1(2), BRD9, and CECR2 Bromodomains by Crawford, Terry D, Tsui, Vickie, Flynn, E. Megan, Wang, Shumei, Taylor, Alexander M, Côté, Alexandre, Audia, James E, Beresini, Maureen H, Burdick, Daniel J, Cummings, Richard, Dakin, Les A, Duplessis, Martin, Good, Andrew C, Hewitt, Michael C, Huang, Hon-Ren, Jayaram, Hariharan, Kiefer, James R, Jiang, Ying, Murray, Jeremy, Nasveschuk, Christopher G, Pardo, Eneida, Poy, Florence, Romero, F. Anthony, Tang, Yong, Wang, Jian, Xu, Zhaowu, Zawadzke, Laura E, Zhu, Xiaoyu, Albrecht, Brian K, Magnuson, Steven R, Bellon, Steve, Cochran, Andrea G

“…The biological role played by non-BET bromodomains remains poorly understood, and it is therefore imperative to identify potent and highly selective inhibitors…”
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Periadventitial atRA citrate-based polyester membranes reduce neointimal hyperplasia and restenosis after carotid injury in rats by Gregory, Elaine K, Webb, Antonio R, Vercammen, Janet M, Flynn, Megan E, Ameer, Guillermo A, Kibbe, Melina R

“…Oral all-trans retinoic acid (atRA) has been shown to reduce the formation of neointimal hyperplasia; however, the dose required was 30 times the…”
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Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637) by Taylor, Alexander M, Côté, Alexandre, Hewitt, Michael C, Pastor, Richard, Leblanc, Yves, Nasveschuk, Christopher G, Romero, F. Anthony, Crawford, Terry D, Cantone, Nico, Jayaram, Hariharan, Setser, Jeremy, Murray, Jeremy, Beresini, Maureen H, de Leon Boenig, Gladys, Chen, Zhongguo, Conery, Andrew R, Cummings, Richard T, Dakin, Leslie A, Flynn, E. Megan, Huang, Oscar W, Kaufman, Susan, Keller, Patricia J, Kiefer, James R, Lai, Tommy, Li, Yingjie, Liao, Jiangpeng, Liu, Wenfeng, Lu, Henry, Pardo, Eneida, Tsui, Vickie, Wang, Jian, Wang, Yongyun, Xu, Zhaowu, Yan, Fen, Yu, Dong, Zawadzke, Laura, Zhu, Xiaoqin, Zhu, Xiaoyu, Sims, Robert J, Cochran, Andrea G, Bellon, Steve, Audia, James E, Magnuson, Steven, Albrecht, Brian K

“…CBP and EP300 are highly homologous, bromodomain-containing transcription coactivators involved in numerous cellular pathways relevant to oncology. As part of…”
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GNE-371, a Potent and Selective Chemical Probe for the Second Bromodomains of Human Transcription-Initiation-Factor TFIID Subunit 1 and Transcription-Initiation-Factor TFIID Subunit 1‑like by Wang, Shumei, Tsui, Vickie, Crawford, Terry D, Audia, James E, Burdick, Daniel J, Beresini, Maureen H, Côté, Alexandre, Cummings, Richard, Duplessis, Martin, Flynn, E. Megan, Hewitt, Michael C, Huang, Hon-Ren, Jayaram, Hariharan, Jiang, Ying, Joshi, Shivangi, Murray, Jeremy, Nasveschuk, Christopher G, Pardo, Eneida, Poy, Florence, Romero, F. Anthony, Tang, Yong, Taylor, Alexander M, Wang, Jian, Xu, Zhaowu, Zawadzke, Laura E, Zhu, Xiaoyu, Albrecht, Brian K, Magnuson, Steven R, Bellon, Steve, Cochran, Andrea G

“…The biological functions of the dual bromodomains of human transcription-initiation-factor TFIID subunit 1 (TAF1­(1,2)) remain unknown, although TAF1 has been…”
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Structural and Biophysical Characterization of the Mycobacterium tuberculosis Protein Rv0577, a Protein Associated with Neutral Red Staining of Virulent Tuberculosis Strains and Homologue of the Streptomyces coelicolor Protein KbpA by Buchko, Garry W, Echols, Nathaniel, Flynn, E. Megan, Ng, Ho-Leung, Stephenson, Samuel, Kim, Heung-Bok, Myler, Peter J, Terwilliger, Thomas C, Alber, Tom, Kim, Chang-Yub

“…Mycobacterium tuberculosis protein Rv0577 is a prominent antigen in tuberculosis patients, the component responsible for neutral red staining of virulent…”
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Endoscopic Gluteus Medius Repair Replicates Open, Knotless Repair With Similar Cyclic Loading Properties: A Cadaveric Study by Flynn, Megan E., Beason, David P., Bartush, Katherine C., Ryan, Michael K., Emblom, Benton A.

“…To compare the repair strength, gap formation, and mode of failure between endoscopic and open double-row gluteus medius repairs in a cadaveric model. Six…”
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Long-term effect of PROLI/NO on cellular proliferation and phenotype after arterial injury by Bahnson, Edward S.M., Vavra, Ashley K., Flynn, Megan E., Vercammen, Janet M., Jiang, Qun, Schwartz, Amanda R., Kibbe, Melina R.

“…Vascular interventions are associated with high failure rates from restenosis secondary to negative remodeling and neointimal hyperplasia. Periadventitial…”
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