Search Results - "Flury, Valentin"
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Accurate Recycling of Parental Histones Reproduces the Histone Modification Landscape during DNA Replication
Published in Molecular cell (18-10-2018)“…Chromatin organization is disrupted genome-wide during DNA replication. On newly synthesized DNA, nucleosomes are assembled from new naive histones and old…”
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The Histone Acetyltransferase Mst2 Protects Active Chromatin from Epigenetic Silencing by Acetylating the Ubiquitin Ligase Brl1
Published in Molecular cell (20-07-2017)“…Faithful propagation of functionally distinct chromatin states is crucial for maintaining cellular identity, and its breakdown can lead to diseases such as…”
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An enhancer screen identifies new suppressors of small-RNA-mediated epigenetic gene silencing
Published in PLoS genetics (22-06-2021)“…Small non-protein coding RNAs are involved in pathways that control the genome at the level of chromatin. In Schizosaccharomyces pombe , small interfering RNAs…”
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Safeguarding the epigenome through the cell cycle: a multitasking game
Published in Current opinion in genetics & development (01-04-2024)“…Sustaining cell identity and function across cell division is germane to human development, healthspan, and cancer avoidance. This relies significantly on…”
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The development of machine learning in lung surgery: A narrative review
Published in Frontiers in surgery (12-09-2022)“…Background Machine learning reflects an artificial intelligence that allows applications to improve their accuracy to predict outcomes, eliminating the need to…”
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NASP maintains histone H3-H4 homeostasis through two distinct H3 binding modes
Published in Nucleic acids research (20-05-2022)“…Histone chaperones regulate all aspects of histone metabolism. NASP is a major histone chaperone for H3-H4 dimers critical for preventing histone degradation…”
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Recycling of modified H2A-H2B provides short-term memory of chromatin states
Published in Cell (02-03-2023)“…Chromatin landscapes are disrupted during DNA replication and must be restored faithfully to maintain genome regulation and cell identity. The histone H3-H4…”
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The Paf1 complex represses small-RNA-mediated epigenetic gene silencing
Published in Nature (London) (09-04-2015)“…The fission yeast is shown to have a mechanism to prevent small RNAs from inducing heterochromatin and epigenetic gene silencing; this protective model…”
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Differential phosphorylation of Clr4SUV39H by Cdk1 accompanies a histone H3 methylation switch that is essential for gametogenesis
Published in EMBO reports (09-01-2023)“…Methylation of histone H3 at lysine 9 (H3K9) is a hallmark of heterochromatin that plays crucial roles in gene silencing, genome stability, and chromosome…”
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Differential phosphorylation of Clr4 SUV39H by Cdk1 accompanies a histone H3 methylation switch that is essential for gametogenesis
Published in EMBO reports (09-01-2023)“…Methylation of histone H3 at lysine 9 (H3K9) is a hallmark of heterochromatin that plays crucial roles in gene silencing, genome stability, and chromosome…”
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Quantifying propagation of DNA methylation and hydroxymethylation with iDEMS
Published in Nature cell biology (01-01-2023)“…DNA methylation is a critical epigenetic mark in mammalian cells. Many aspects of DNA methylation maintenance have been characterized; however, the exact…”
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Symmetric inheritance of parental histones governs epigenome maintenance and embryonic stem cell identity
Published in Nature genetics (01-09-2023)“…Modified parental histones are segregated symmetrically to daughter DNA strands during replication and can be inherited through mitosis. How this may sustain…”
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Characterization of Phosphorylation- and RNA-Dependent UPF1 Interactors by Quantitative Proteomics
Published in Journal of proteome research (06-06-2014)“…Human up-frameshift 1 (UPF1) is an ATP-dependent RNA helicase and phosphoprotein implicated in several biological processes but is best known for its key…”
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