Search Results - "Fluegel, Alexander"

Global Model for Calculating Room-Temperature Glass Density from the Composition by Fluegel, Alexander

“…A large silicate glass density database including 6719 compositions, obtained from SciGlass© and other published sources, was systematically analyzed for…”
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On the role of halides and thiols in additive-assisted copper electroplating by Huynh, Thi M.T., Weiss, Florian, Hai, Nguyen T.M., Reckien, Werner, Bredow, Thomas, Fluegel, Alexander, Arnold, Marco, Mayer, Dieter, Keller, Hubert, Broekmann, Peter

“…► We study the synergistic and antagonistic interactions among halides, SPS and suppressor additives relevant for Damascene copper electroplating. ► The…”
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The CNS Immune Landscape from the Viewpoint of a T Cell by Mundt, Sarah, Greter, Melanie, Flügel, Alexander, Becher, Burkhard

“…Neuro-immune interactions are not only vital for the control of neurotropic pathogens, but also appear to influence brain development and homeostasis. During…”
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Body–brain axis: orchestrating immune responses by Hosang, Leon, Flügel, Alexander, Odoardi, Francesca

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Intravital real-time analysis of T-cell activation in health and disease by Lodygin, Dmitri, Flügel, Alexander

“…Graphical abstract…”
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Vascular, glial, and lymphatic immune gateways of the central nervous system by Engelhardt, Britta, Carare, Roxana O., Bechmann, Ingo, Flügel, Alexander, Laman, Jon D., Weller, Roy O.

“…Immune privilege of the central nervous system (CNS) has been ascribed to the presence of a blood–brain barrier and the lack of lymphatic vessels within the…”
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Effector T-cell trafficking between the leptomeninges and the cerebrospinal fluid by Schläger, Christian, Körner, Henrike, Krueger, Martin, Vidoli, Stefano, Haberl, Michael, Mielke, Dorothee, Brylla, Elke, Issekutz, Thomas, Cabañas, Carlos, Nelson, Peter J., Ziemssen, Tjalf, Rohde, Veit, Bechmann, Ingo, Lodygin, Dmitri, Odoardi, Francesca, Flügel, Alexander

“…By investigating trafficking of autoreactive T cells into the CSF during experimental autoimmune encephalitis, the authors find that T cells enter the CSF from…”
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Distinct roles of the meningeal layers in CNS autoimmunity by Merlini, Arianna, Haberl, Michael, Strauß, Judith, Hildebrand, Luisa, Genc, Nafiye, Franz, Jonas, Chilov, Dmitri, Alitalo, Kari, Flügel-Koch, Cassandra, Stadelmann, Christine, Flügel, Alexander, Odoardi, Francesca

“…The meninges, comprising the leptomeninges (pia and arachnoid layers) and the pachymeninx (dura layer), participate in central nervous system (CNS)…”
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β-Synuclein-reactive T cells induce autoimmune CNS grey matter degeneration by Lodygin, Dmitri, Hermann, Moritz, Schweingruber, Nils, Flügel-Koch, Cassandra, Watanabe, Takashi, Schlosser, Corinna, Merlini, Arianna, Körner, Henrike, Chang, Hsin-Fang, Fischer, Henrike J., Reichardt, Holger M., Zagrebelsky, Marta, Mollenhauer, Brit, Kügler, Sebastian, Fitzner, Dirk, Frahm, Jens, Stadelmann, Christine, Haberl, Michael, Odoardi, Francesca, Flügel, Alexander

“…The grey matter is a central target of pathological processes in neurodegenerative disorders such as Parkinson’s and Alzheimer’s diseases. The grey matter is…”
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T cells become licensed in the lung to enter the central nervous system by Odoardi, Francesca, Sie, Christopher, Streyl, Kristina, Ulaganathan, Vijay K., Schläger, Christian, Lodygin, Dmitri, Heckelsmiller, Klaus, Nietfeld, Wilfried, Ellwart, Joachim, Klinkert, Wolfgang E. F., Lottaz, Claudio, Nosov, Mikhail, Brinkmann, Volker, Spang, Rainer, Lehrach, Hans, Vingron, Martin, Wekerle, Hartmut, Flügel-Koch, Cassandra, Flügel, Alexander

“…A Lewis rat model of experimental autoimmune encephalomyelitis is used to show that on their way to the CNS, encephalitogenic T-cell blasts are temporarily…”
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Angiopoietin-2 blockade ameliorates autoimmune neuroinflammation by inhibiting leukocyte recruitment into the CNS by Li, Zhilin, Korhonen, Emilia A, Merlini, Arianna, Strauss, Judith, Wihuri, Eleonoora, Nurmi, Harri, Antila, Salli, Paech, Jennifer, Deutsch, Urban, Engelhardt, Britta, Chintharlapalli, Sudhakar, Koh, Gou Young, Flügel, Alexander, Alitalo, Kari

“…Angiopoietin-2 (Ang2), a ligand of the endothelial Tie2 tyrosine kinase, is involved in vascular inflammation and leakage in critically ill patients. However,…”
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Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions by Bartholomäus, Ingo, Kawakami, Naoto, Odoardi, Francesca, Schläger, Christian, Miljkovic, Djordje, Ellwart, Joachim W., Klinkert, Wolfgang E. F., Flügel-Koch, Cassandra, Issekutz, Thomas B., Wekerle, Hartmut, Flügel, Alexander

“…T cells in autoimmunity A two-photon fluorescence microscopy study of rats with experimental autoimmune encephalomyelitis — a model for multiple sclerosis —…”
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Autoantibody-boosted T-cell reactivation in the target organ triggers manifestation of autoimmune CNS disease by Flach, Anne-Christine, Litke, Tanja, Strauss, Judith, Haberl, Michael, Gómez, César Cordero, Reindl, Markus, Saiz, Albert, Fehling, Hans-Jörg, Wienands, Jürgen, Odoardi, Francesca, Lühder, Fred, Flügel, Alexander

“…Multiple sclerosis (MS) is caused by T cells that are reactive for brain antigens. In experimental autoimmune encephalomyelitis, the animal model for MS,…”
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Knocking at the brain’s door: intravital two-photon imaging of autoreactive T cell interactions with CNS structures by Kawakami, Naoto, Flügel, Alexander

“…Since the first applications of two-photon microscopy in immunology 10 years ago, the number of studies using this advanced technology has increased…”
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Myelin insulation as a risk factor for axonal degeneration in autoimmune demyelinating disease by Schäffner, Erik, Bosch-Queralt, Mar, Edgar, Julia M., Lehning, Maria, Strauß, Judith, Fleischer, Niko, Kungl, Theresa, Wieghofer, Peter, Berghoff, Stefan A., Reinert, Tilo, Krueger, Martin, Morawski, Markus, Möbius, Wiebke, Barrantes-Freer, Alonso, Stieler, Jens, Sun, Ting, Saher, Gesine, Schwab, Markus H., Wrede, Christoph, Frosch, Maximilian, Prinz, Marco, Reich, Daniel S., Flügel, Alexander, Stadelmann, Christine, Fledrich, Robert, Nave, Klaus-Armin, Stassart, Ruth M.

“…Axonal degeneration determines the clinical outcome of multiple sclerosis and is thought to result from exposure of denuded axons to immune-mediated damage…”
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CD28-signaling can be partially compensated in CD28-knockout mice but is essential for virus elimination in a murine model of multiple sclerosis by Hülskötter, Kirsten, Lühder, Fred, Leitzen, Eva, Flügel, Alexander, Baumgärtner, Wolfgang

“…The intracerebral infection of mice with Theiler's murine encephalomyelitis virus (TMEV) represents a well-established animal model for multiple sclerosis…”
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TFEB activation hallmarks antigenic experience of B lymphocytes and directs germinal center fate decisions by Münchhalfen, Matthias, Görg, Richard, Haberl, Michael, Löber, Jens, Willenbrink, Jakob, Schwarzt, Laura, Höltermann, Charlotte, Ickes, Christian, Hammermann, Leonard, Kus, Jan, Chapuy, Björn, Ballabio, Andrea, Reichardt, Sybille D., Flügel, Alexander, Engels, Niklas, Wienands, Jürgen

“…Ligation of the B cell antigen receptor (BCR) initiates humoral immunity. However, BCR signaling without appropriate co-stimulation commits B cells to death…”
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Double‐edged effects of tamoxifen‐in‐oil‐gavage on an infectious murine model for multiple sclerosis by Hülskötter, Kirsten, Jin, Wen, Allnoch, Lisa, Hansmann, Florian, Schmidtke, Daniel, Rohn, Karl, Flügel, Alexander, Lühder, Fred, Baumgärtner, Wolfgang, Herder, Vanessa

“…Tamoxifen gavage is a commonly used method to induce genetic modifications in cre‐loxP systems. As a selective estrogen receptor modulator (SERM), the compound…”
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A combination of fluorescent NFAT and H2B sensors uncovers dynamics of T cell activation in real time during CNS autoimmunity by Lodygin, Dmitri, Odoardi, Francesca, Schläger, Christian, Körner, Henrike, Kitz, Alexandra, Nosov, Michail, van den Brandt, Jens, Reichardt, Holger M, Haberl, Michael, Flügel, Alexander

“…The work of Dmitri Lodygin and his colleagues focuses on the important issue of when and where autoaggressive T cells are activated within their target organ…”
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Tamoxifen Application Is Associated with Transiently Increased Loss of Hippocampal Neurons following Virus Infection by Hülskötter, Kirsten, Lühder, Fred, Flügel, Alexander, Herder, Vanessa, Baumgärtner, Wolfgang

“…Tamoxifen is frequently used in murine knockout systems with CreER/LoxP. Besides possible neuroprotective effects, tamoxifen is described as having a negative…”
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