Search Results - "Flucke, Uta"

Unraveling schwannomas by Flucke, Uta E, Hiemcke-Jiwa, Laura S, Wesseling, Pieter

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USP6-Associated Neoplasms: A Rapidly Expanding Family of Lesions by Hiemcke-Jiwa, Laura S., van Gorp, Joost M., Fisher, Cyril, Creytens, David, van Diest, Paul J., Flucke, Uta

“…Nearly 20 years ago, the first description of a translocation involving chromosome 17 on which USP6 resides was described. Since then, not only the culprit…”
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Androgen deprivation therapy for androgen receptor‐positive advanced salivary duct carcinoma: A nationwide case series of 35 patients in The Netherlands by Boon, Eline, van Boxtel, Wim, Buter, Jan, Baatenburg de Jong, Robert J., van Es, Robert J. J., Bel, Miranda, Fiets, Edward, Oosting, Sjoukje F., Slingerland, Marije, Hoeben, Ann, Tesselaar, Margot E. T., Jonker, Marianne A., Flucke, Uta E., van der Graaf, Winette T. A., van Herpen, Carla M. L.

“…Background Salivary duct carcinoma, an aggressive subtype of salivary gland cancer, is mostly androgen receptor‐positive. Only limited data are available on…”
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PHF1 fusions cause distinct gene expression and chromatin accessibility profiles in ossifying fibromyxoid tumors and mesenchymal cells by Hofvander, Jakob, Jo, Vickie Y., Fletcher, Christopher D. M., Puls, Florian, Flucke, Uta, Nilsson, Jenny, Magnusson, Linda, Mertens, Fredrik

“…Ossifying fibromyxoid tumor (OFMT) is a soft tissue tumor frequently displaying gene fusions, most of which affect the PHF1 gene. PHF1 encodes plant…”
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Collective cancer invasion forms an integrin-dependent radioresistant niche by Haeger, Anna, Alexander, Stephanie, Vullings, Manon, Kaiser, Fabian M P, Veelken, Cornelia, Flucke, Uta, Koehl, Gudrun E, Hirschberg, Markus, Flentje, Michael, Hoffman, Robert M, Geissler, Edward K, Kissler, Stephan, Friedl, Peter

“…Cancer fatalities result from metastatic dissemination and therapy resistance, both processes that depend on signals from the tumor microenvironment. To…”
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Intimal sarcomas and undifferentiated cardiac sarcomas carry mutually exclusive MDM2, MDM4, and CDK6 amplifications and share a common DNA methylation signature by Koelsche, Christian, Benhamida, Jamal K., Kommoss, Felix K. F., Stichel, Damian, Jones, David T. W., Pfister, Stefan M., Heilig, Christoph E., Fröhling, Stefan, Stenzinger, Albrecht, Buslei, Rolf, Mentzel, Thomas, Baumhoer, Daniel, Ladanyi, Marc, Antonescu, Cristina R., Flucke, Uta, Gorp, Joost van, Bode-Lesniewska, Beata, Deimling, Andreas von, Mechtersheimer, Gunhild

“…Undifferentiated mesenchymal tumors arising from the inner lining (intima) of large arteries are classified as intimal sarcomas (ISA) with MDM2 amplification…”
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Myxoid pleomorphic liposarcoma—a clinicopathologic, immunohistochemical, molecular genetic and epigenetic study of 12 cases, suggesting a possible relationship with conventional pleomorphic liposarcoma by Creytens, David, Folpe, Andrew L., Koelsche, Christian, Mentzel, Thomas, Ferdinande, Liesbeth, van Gorp, Joost M., Van der Linden, Malaïka, Raman, Lennart, Menten, Björn, Fritchie, Karen, von Deimling, Andreas, Van Dorpe, Jo, Flucke, Uta

“…Myxoid pleomorphic liposarcoma is a recently defined subtype of liposarcoma, which preferentially involves the mediastinum of young patients and shows mixed…”
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A nationwide cohort study on treatment and survival in patients with malignant peripheral nerve sheath tumours by Martin, Enrico, Coert, J. Henk, Flucke, Uta E., Slooff, Willem-Bart M., Ho, Vincent K.Y., van der Graaf, Winette T., van Dalen, Thijs, van de Sande, Michiel A.J., van Houdt, Winan J., Grünhagen, Dirk J., Verhoef, Cornelis

“…Despite curative intents of treatment in localized malignant peripheral nerve sheath tumours (MPNSTs), prognosis remains poor. This study investigated survival…”
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Novel EWSR1-SMAD3 Gene Fusions in a Group of Acral Fibroblastic Spindle Cell Neoplasms by Kao, Yu-Chien, Flucke, Uta, Eijkelenboom, Astrid, Zhang, Lei, Sung, Yun-Shao, Suurmeijer, Albert J.H, Antonescu, Cristina R

“…Benign/low-grade fibroblastic tumors encompass a broad spectrum of tumors with different morphologies and molecular genetic abnormalities. However, despite…”
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Treatment of malignant peripheral nerve sheath tumors in pediatric NF1 disease by Martin, Enrico, Flucke, Uta E., Coert, J. Henk, van Noesel, Max M.

“…Background Malignant peripheral nerve sheath tumors (MPNSTs) are rare yet highly aggressive soft tissue sarcomas. Children with neurofibromatosis type 1 (NF1)…”
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Targeting the FAK-Src Complex in Desmoplastic Small Round Cell Tumors, Ewing Sarcoma, and Rhabdomyosarcoma by van Erp, Anke E. M., Hillebrandt-Roeffen, Melissa H. S., van Bree, Niek F. H. N., Plüm, Tim A., Flucke, Uta. E., Desar, Ingrid M. E., Fleuren, Emmy D. G., van der Graaf, Winette T. A., Versleijen-Jonkers, Yvonne M. H.

“…Desmoplastic small round cell tumors (DSRCTs), Ewing sarcoma (ES), and alveolar and embryonal rhabdomyosarcoma (ARMS and ERMS) are malignant sarcomas typically…”
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DNA Methylation Profiling Identifies Distinct Clusters in Angiosarcomas by Weidema, Marije E, van de Geer, Ellen, Koelsche, Christian, Desar, Ingrid M E, Kemmeren, Patrick, Hillebrandt-Roeffen, Melissa H S, Ho, Vincent K Y, van der Graaf, Winette T A, Versleijen-Jonkers, Yvonne M H, von Deimling, Andreas, Flucke, Uta E

“…DNA methylation profiling has previously uncovered biologically and clinically meaningful subgroups within many tumor types, but was not yet performed in…”
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EWSR1-ATF1 chimeric transcript in a myoepithelial tumor of soft tissue: a case report by Flucke, Uta, MD, Mentzel, Thomas, MD, Verdijk, Marian A., MSc, Slootweg, Pieter J., MD, DMD, PhD, Creytens, David H., MD, Suurmeijer, Albert J.H., MD, PhD, Tops, Bastiaan B.J., PhD

“…Summary Soft tissue myoepithelial tumors, a recently defined entity, include benign and malignant lesions showing a considerable morphological and…”
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Atypical fibroxanthoma and pleomorphic dermal sarcoma: Is superficial infiltration in subcutaneous tissue acceptable in AFX? by van Midden, Dominique, Flucke, Uta E., Amir, Avital L., Bonenkamp, Johannes J., Lubeek, Satish F.K., Blokx, Willeke A.M.

“…Atypical fibroxanthoma (AFX) and pleomorphic dermal sarcoma (PDS) are rare cutaneous neoplasms forming a spectrum. Case reports with recurrences and metastasis…”
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Comprehensive molecular and clinicopathological analysis of vascular malformations: A study of 319 cases by Ten Broek, Roel W., Eijkelenboom, Astrid, Vleuten, Carine J. M., Kamping, Eveline J., Kets, Marleen, Verhoeven, Bas H., Grünberg, Katrien, Schultze Kool, Leo J., Tops, Bastiaan B. J., Ligtenberg, Marjolijn J. L., Flucke, Uta

“…Vascular malformations are part of overgrowth syndromes characterized by somatic mosaic mutations or rarely by germline mutations. Due to their similarities…”
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Establishment and characterization of the first patient-derived radiation-induced angiosarcoma xenograft model (RT-AS5) by Versleijen-Jonkers, Yvonne M. H., Hillebrandt-Roeffen, Melissa H. S., Weidema, Marije E., Mooren, Jeroen, von Rhein, Daniel T., de Bitter, Tessa J. J., Kroeze, Leonie I., Desar, Ingrid M. E., Flucke, Uta E.

“…Angiosarcomas are a heterogeneous group of rare endothelial malignancies with a complex, not completely unravelled biology. They encompass primary…”
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Cellular angiofibroma: analysis of 25 cases emphasizing its relationship to spindle cell lipoma and mammary-type myofibroblastoma by Flucke, Uta, van Krieken, J Han JM, Mentzel, Thomas

“…Cellular angiofibroma represents a rare benign mesenchymal tumor, occurring mainly in the superficial soft tissue of the genital region. The involvement of…”
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Odontogenic Myxomas Harbor Recurrent Copy Number Alterations and a Distinct Methylation Signature by Kleijn, Tony G, Ameline, Baptiste, Schreuder, Willem H, Kooistra, Wierd, Doff, Jan J, Witjes, Max, Pichardo, Sarina E C, Lausová, Tereza, Koppes, Sjors A, van den Hout, Mari F C M, van Engen-van Grunsven, Ilse C H, Flucke, Uta E, de Lange, Jan, Szuhai, Karoly, Briaire-de Bruijn, Inge H, Savci-Heijink, Dilara C, Suurmeijer, Albert J H, Bovée, Judith V M G, von Deimling, Andreas, Baumhoer, Daniel, Cleven, Arjen H G

“…Odontogenic myxoma is a rare, benign, and locally aggressive tumor that develops in the tooth-bearing areas of the jaw. The molecular mechanisms underlying…”
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Non-cytotoxic systemic treatment in malignant peripheral nerve sheath tumors (MPNST): A systematic review from bench to bedside by Martin, Enrico, Lamba, Nayan, Flucke, Uta E., Verhoef, C., Coert, J. Henk, Versleijen-Jonkers, Yvonne M.H., Desar, Ingrid M.E.

“…•To date, no systemic treatment has yet proven clinical efficacy in MPNSTs.•In vivo studies show promising results targeting PI3K/Akt/mTOR and VEGFR…”
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Combination of docetaxel, trastuzumab and pertuzumab or treatment with trastuzumab-emtansine for metastatic salivary duct carcinoma by van Boxtel, Wim, Boon, Eline, Weijs, Willem L.J., van den Hoogen, Frank J.A., Flucke, Uta E., van Herpen, Carla M.L.

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