Search Results - "Flucher, Bernhard E."

Skeletal muscle CaV1.1 channelopathies by Flucher, Bernhard E.

“…Ca V 1.1 is specifically expressed in skeletal muscle where it functions as voltage sensor of skeletal muscle excitation-contraction (EC) coupling…”
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The Role of Auxiliary Subunits for the Functional Diversity of Voltage-Gated Calcium Channels by Campiglio, Marta, Flucher, Bernhard E.

“…Voltage‐gated calcium channels (VGCCs) represent the sole mechanism to convert membrane depolarization into cellular functions like secretion, contraction, or…”
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Molecular Interactions in the Voltage Sensor Controlling Gating Properties of CaV Calcium Channels by Tuluc, Petronel, Yarov-Yarovoy, Vladimir, Benedetti, Bruno, Flucher, Bernhard E.

“…Voltage-gated calcium channels (CaV) regulate numerous vital functions in nerve and muscle cells. To fulfill their diverse functions, the multiple members of…”
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Postsynaptic CaV1.1-driven calcium signaling coordinates presynaptic differentiation at the developing neuromuscular junction by Kaplan, Mehmet Mahsum, Flucher, Bernhard E.

“…Proper formation of neuromuscular synapses requires the reciprocal communication between motor neurons and muscle cells. Several anterograde and retrograde…”
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Retrograde Coupling: Muscle’s Orphan Signaling Pathway? by Flucher, Bernhard E.

“…In skeletal muscle excitation-contraction coupling, a voltage-gated calcium channel directly activates opening of the calcium release channel (RyR1) in the…”
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CaV1.1 voltage-sensing domain III exclusively controls skeletal muscle excitation-contraction coupling by Pelizzari, Simone, Heiss, Martin C., Fernández-Quintero, Monica L., El Ghaleb, Yousra, Liedl, Klaus R., Tuluc, Petronel, Campiglio, Marta, Flucher, Bernhard E.

“…Skeletal muscle contractions are initiated by action potentials, which are sensed by the voltage-gated calcium channel (Ca V 1.1) and are conformationally…”
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Molecular Interactions in the Voltage Sensor Controlling Gating Properties of Ca V Calcium Channels by Tuluc, Petronel, Yarov-Yarovoy, Vladimir, Benedetti, Bruno, Flucher, Bernhard E.

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A homozygous missense variant in CACNB4 encoding the auxiliary calcium channel beta4 subunit causes a severe neurodevelopmental disorder and impairs channel and non-channel functions by Coste de Bagneaux, Pierre, von Elsner, Leonie, Bierhals, Tatjana, Campiglio, Marta, Johannsen, Jessika, Obermair, Gerald J, Hempel, Maja, Flucher, Bernhard E, Kutsche, Kerstin

“…P/Q-type channels are the principal presynaptic calcium channels in brain functioning in neurotransmitter release. They are composed of the pore-forming CaV2.1…”
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How is SR calcium release in muscle modulated by PIP(4,5)2? by Flucher, Bernhard E

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Restricting calcium currents is required for correct fiber type specification in skeletal muscle by Sultana, Nasreen, Dienes, Beatrix, Benedetti, Ariane, Tuluc, Petronel, Szentesi, Peter, Sztretye, Monika, Rainer, Johannes, Hess, Michael W, Schwarzer, Christoph, Obermair, Gerald J, Csernoch, Laszlo, Flucher, Bernhard E

“…Skeletal muscle excitation-contraction (EC) coupling is independent of calcium influx. In fact, alternative splicing of the voltage-gated calcium channel…”
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Structural determinants of voltage-gating properties in calcium channels by Fernández-Quintero, Monica L, El Ghaleb, Yousra, Tuluc, Petronel, Campiglio, Marta, Liedl, Klaus R, Flucher, Bernhard E

“…Voltage-gated calcium channels control key functions of excitable cells, like synaptic transmission in neurons and the contraction of heart and skeletal…”
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Physiological and Pharmacological Modulation of the Embryonic Skeletal Muscle Calcium Channel Splice Variant CaV1.1e by Benedetti, Bruno, Tuluc, Petronel, Mastrolia, Vincenzo, Dlaska, Clemens, Flucher, Bernhard E.

“…CaV1.1e is the voltage-gated calcium channel splice variant of embryonic skeletal muscle. It differs from the adult CaV1.1a splice variant by the exclusion of…”
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Counteractive and cooperative actions of muscle β-catenin and CaV1.1 during early neuromuscular synapse formation by Kaplan, Mehmet Mahsum, Flucher, Bernhard E.

“…Activity-dependent calcium signals in developing muscle play a crucial role in neuromuscular junction (NMJ) formation. However, its downstream effectors and…”
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Biophysical classification of a CACNA1D de novo mutation as a high-risk mutation for a severe neurodevelopmental disorder by Hofer, Nadja T, Tuluc, Petronel, Ortner, Nadine J, Nikonishyna, Yuliia V, Fernándes-Quintero, Monica L, Liedl, Klaus R, Flucher, Bernhard E, Cox, Helen, Striessnig, Jörg

“…There is increasing evidence that de novo missense mutations inducing increased Cav1.3 L-type Ca -channel-function confer a high risk for neurodevelopmental…”
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Calcium Influx and Release Cooperatively Regulate AChR Patterning and Motor Axon Outgrowth during Neuromuscular Junction Formation by Kaplan, Mehmet Mahsum, Sultana, Nasreen, Benedetti, Ariane, Obermair, Gerald J., Linde, Nina F., Papadopoulos, Symeon, Dayal, Anamika, Grabner, Manfred, Flucher, Bernhard E.

“…Formation of synapses between motor neurons and muscles is initiated by clustering of acetylcholine receptors (AChRs) in the center of muscle fibers prior to…”
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Spatial transcriptomics in embryonic mouse diaphragm muscle reveals regional gradients and subdomains of developmental gene expression by Kaplan, Mehmet Mahsum, Zeidler, Maximilian, Knapp, Annabella, Hölzl, Martina, Kress, Michaela, Fritsch, Helga, Krogsdam, Anne, Flucher, Bernhard E.

“…The murine embryonic diaphragm is a primary model for studying myogenesis and neuro-muscular synaptogenesis, both representing processes regulated by spatially…”
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A Polybasic Plasma Membrane Binding Motif in the I-II Linker Stabilizes Voltage-gated CaV1.2 Calcium Channel Function by Kaur, Gurjot, Pinggera, Alexandra, Ortner, Nadine J., Lieb, Andreas, Sinnegger-Brauns, Martina J., Yarov-Yarovoy, Vladimir, Obermair, Gerald J., Flucher, Bernhard E., Striessnig, Jörg

“…L-type voltage-gated Ca2+ channels (LTCCs) regulate many physiological functions like muscle contraction, hormone secretion, gene expression, and neuronal…”
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STAC proteins: The missing link in skeletal muscle EC coupling and new regulators of calcium channel function by Flucher, Bernhard E., Campiglio, Marta

“…Excitation-contraction coupling is the signaling process by which action potentials control calcium release and consequently the force of muscle contraction…”
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A new L-type calcium channel isoform required for normal patterning of the developing neuromuscular junction by Flucher, Bernhard E., Tuluc, Petronel

“…One of the earliest steps in the development of the neuromuscular junction (NMJ) is the pre-patterning of acetylcholine receptors (AChR) in the center of…”
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How and why are calcium currents curtailed in the skeletal muscle voltage‐gated calcium channels? by Flucher, Bernhard E., Tuluc, Petronel

“…Voltage‐gated calcium channels represent the sole mechanism converting electrical signals of excitable cells into cellular functions such as contraction,…”
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