Search Results - "Flowers, Sarah"

APOE in the normal brain by Flowers, Sarah A., Rebeck, G. William

“…The APOE4 protein affects the primary neuropathological markers of Alzheimer's disease (AD): amyloid plaques, neurofibrillary tangles, and gliosis. These…”
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Single-Crystal and Electronic Structure of a 1.3 nm Indium Phosphide Nanocluster by Gary, Dylan C, Flowers, Sarah E, Kaminsky, Werner, Petrone, Alessio, Li, Xiaosong, Cossairt, Brandi M

“…Magic-sized nanoclusters have been implicated as mechanistically relevant intermediates in the synthesis of group III-V quantum dots. Herein we report the…”
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O-glycosylation on cerebrospinal fluid and plasma apolipoprotein E differs in the lipid-binding domain by Flowers, Sarah A, Grant, Oliver C, Woods, Robert J, Rebeck, G William

“…The O-glycoprotein apolipoprotein E (APOE), the strongest genetic risk factor for Alzheimer's disease, associates with lipoproteins. Cerebrospinal fluid (CSF)…”
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Separation of Sialylated Glycan Isomers by Differential Mobility Spectrometry by Lane, Catherine S, McManus, Kirsty, Widdowson, Philip, Flowers, Sarah A, Powell, Gerard, Anderson, Ian, Campbell, J. Larry

“…Mass spectrometry has proven itself to be an important technology for characterizing intact glycoproteins, glycopeptides, and released glycans. However, these…”
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Reduced Mucin-7 (Muc7) Sialylation and Altered Saliva Rheology in Sjögren's Syndrome Associated Oral Dryness by Chaudhury, Nayab M.A., Proctor, Gordon B., Karlsson, Niclas G., Carpenter, Guy H., Flowers, Sarah A.

“…Sjögren's syndrome is a chronic autoimmune disorder characterized by lymphocytic infiltration and hypofunction of salivary and lacrimal glands. This loss of…”
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Mono- and Dimetalation of a Tridentate Bisimidazole-Phosphine Ligand by Flowers, Sarah E, Cossairt, Brandi M

“…A bisimidazole-phosphine ligand, PhP[(CH2)2ImArMe2]2, has been prepared and has been metalated using [Cp*Ru(μ3-Cl)]4, generating a bis(N-heterocyclic…”
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Polychlorinated biphenyls induce oxidative stress and metabolic responses in astrocytes by McCann, Mondona S., Fernandez, Harvey R., Flowers, Sarah A., Maguire-Zeiss, Kathleen A.

“…•Astrocytes exposed to PCBs demonstrate an increase in reactive oxygen species in the absence of cell death.•Astrocytes exposed to PCBs exhibit increased…”
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Benfotiamine and Cognitive Decline in Alzheimer's Disease: Results of a Randomized Placebo-Controlled Phase IIa Clinical Trial by Gibson, Gary E, Luchsinger, José A, Cirio, Rosanna, Chen, Huanlian, Franchino-Elder, Jessica, Hirsch, Joseph A, Bettendorff, Lucien, Chen, Zhengming, Flowers, Sarah A, Gerber, Linda M, Grandville, Thomas, Schupf, Nicole, Xu, Hui, Stern, Yaakov, Habeck, Christian, Jordan, Barry, Fonzetti, Pasquale

“…In preclinical models, benfotiamine efficiently ameliorates the clinical and biological pathologies that define Alzheimer's disease (AD) including impaired…”
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Cancer Chemotherapy Related Cognitive Impairment and the Impact of the Alzheimer's Disease Risk Factor APOE by Fernandez, Harvey R, Varma, Ashima, Flowers, Sarah A, Rebeck, George William

“…Cancer related cognitive impairment (CRCI) is a serious impairment to maintaining quality of life in cancer survivors. Cancer chemotherapy contributes to this…”
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Protocol for a seamless phase 2A-phase 2B randomized double-blind placebo-controlled trial to evaluate the safety and efficacy of benfotiamine in patients with early Alzheimer's disease (BenfoTeam) by Feldman, Howard H, Luchsinger, José A, Léger, Gabriel C, Taylor, Curtis, Jacobs, Diane M, Salmon, David P, Edland, Steven D, Messer, Karen, Revta, Carolyn, Flowers, Sarah A, Jones, Kerry S, Koulman, Albert, Yarasheski, Kevin E, Verghese, Philip B, Venkatesh, Venky, Zetterberg, Henrik, Durant, January, Lupo, Jody-Lynn, Gibson, Gary E

“…Benfotiamine provides an important novel therapeutic direction in Alzheimer's disease (AD) with possible additive or synergistic effects to amyloid targeting…”
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Histone deacetylase 6 inhibition rescues axonal transport impairments and prevents the neurotoxicity of HIV-1 envelope protein gp120 by Wenzel, Erin D., Speidell, Andrew, Flowers, Sarah A., Wu, Chengbiao, Avdoshina, Valeria, Mocchetti, Italo

“…Despite successful antiretroviral drug therapy, a subset of human immunodeficiency virus-1 (HIV)-positive individuals still display synaptodendritic…”
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The O-Linked Glycome and Blood Group Antigens ABO on Mucin-Type Glycoproteins in Mucinous and Serous Epithelial Ovarian Tumors by Vitiazeva, Varvara, Kattla, Jayesh J, Flowers, Sarah A, Lindén, Sara K, Premaratne, Pushpa, Weijdegård, Birgitta, Sundfeldt, Karin, Karlsson, Niclas G

“…Mucins are heavily O-glycosylated proteins where the glycosylation has been shown to play an important role in cancer. Normal epithelial ovarian cells do not…”
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Lubricin binds cartilage proteins, cartilage oligomeric matrix protein, fibronectin and collagen II at the cartilage surface by Flowers, Sarah A., Zieba, Agata, Örnros, Jessica, Jin, Chunsheng, Rolfson, Ola, Björkman, Lena I., Eisler, Thomas, Kalamajski, Sebastian, Kamali-Moghaddam, Masood, Karlsson, Niclas G.

“…Lubricin, a heavily O -glycosylated protein, is essential for boundary lubrication of articular cartilage. Strong surface adherence of lubricin is required…”
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Compassionate Care: A Qualitative Exploration of Nurses' Inner Resources in the Face of Burnout by Flowers, Sarah-Louise d'Auvergne, Guillén-Solà, Mireia, Sansó, Noemí, Galiana, Laura

“…There is a universal shortage of nurses, with a current needs-based shortage of 5.9 million. This is not solely a recruitment issue but one of retention,…”
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Deciphering Isomers with a Multiple Reaction Monitoring Method for the Complete Detectable O‑Glycan Repertoire of the Candidate Therapeutic, Lubricin by Flowers, Sarah A, Lane, Catherine S, Karlsson, Niclas G

“…Glycosylation is a fundamental post-translational modification, occurring on half of all proteins. Despite its significance, our understanding is limited, in…”
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Pyrazole-Based PCN Pincer Complexes of Palladium(II): Mono- and Dinuclear Hydroxide Complexes and Ligand Rollover C–H Activation by Bailey, Wilson D, Luconi, Lapo, Rossin, Andrea, Yakhvarov, Dmitry, Flowers, Sarah E, Kaminsky, Werner, Kemp, Richard A, Giambastiani, Giuliano, Goldberg, Karen I

“…Palladium complexes of the novel unsymmetrical phosphine pyrazole-containing pincer ligands PCNH (PCNH =…”
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The Spanish Version of the State Self-Compassion Scale–Long Form (SSCS–L): A Study of Its Validity and Reliability in a Sample of Nursing Students by Galiana, Laura, Guillén, Mireia, Pades, Antonia, Flowers, Sarah L., Vidal-Blanco, Gabriel, Sansó, Noemí

“…Background: In nurses, self-compassion mitigates the effects of stress, burnout and compassion fatigue, and enhances empathy, compassion and well-being and…”
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The O-glycomap of Lubricin, a Novel Mucin Responsible for Joint Lubrication, Identified by Site-specific Glycopeptide Analysis by Ali, Liaqat, Flowers, Sarah A., Jin, Chunsheng, Bennet, Eric Paul, Ekwall, Anna-Karin H., Karlsson, Niclas G.

“…The lubricative, heavily glycosylated mucin-like synovial glycoprotein lubricin has previously been observed to contain glycosylation changes related to…”
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Uncovering the dominant role of root metabolism in shaping rhizosphere metabolome under drought in tropical rainforest plants by Hildebrand, Gina A., Honeker, Linnea K., Freire-Zapata, Viviana, Ayala-Ortiz, Christian, Rajakaruna, Sumudu, Fudyma, Jane, Daber, L. Erik, AminiTabrizi, Roya, Chu, Rosalie L., Toyoda, Jason, Flowers, Sarah E., Hoyt, David W., Hamdan, Rasha, Gil-Loaiza, Juliana, Shi, Lingling, Dippold, Michaela A., Ladd, S. Nemiah, Werner, Christiane, Meredith, Laura K., Tfaily, Malak M.

“…Plant-soil-microbe interactions are crucial for driving rhizosphere processes that contribute to metabolite turnover and nutrient cycling. With the increasing…”
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Elucidating Drought-Tolerance Mechanisms in Plant Roots through 1H NMR Metabolomics in Parallel with MALDI-MS, and NanoSIMS Imaging Techniques by Honeker, Linnea K, Hildebrand, Gina A, Fudyma, Jane D, Daber, L Erik, Hoyt, David, Flowers, Sarah E, Gil-Loaiza, Juliana, Kübert, Angelika, Bamberger, Ines, Anderton, Christopher R, Cliff, John, Leichty, Sarah, AminiTabrizi, Roya, Kreuzwieser, Jürgen, Shi, Lingling, Bai, Xuejuan, Velickovic, Dusan, Dippold, Michaela A, Ladd, S Nemiah, Werner, Christiane, Meredith, Laura K, Tfaily, Malak M

“…As direct mediators between plants and soil, roots play an important role in metabolic responses to environmental stresses such as drought, yet these responses…”
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