Search Results - "Flotte, T"

Clinical gene therapy using recombinant adeno-associated virus vectors by Mueller, C, Flotte, T R

“…Recombinant adeno-associated virus (rAAV) vectors possess a number of properties that may make them suitable for clinical gene therapy, including being based…”
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Gene Therapy 2017: Progress and Future Directions by Keeler, AM, ElMallah, MK, Flotte, TR

“…[...]because CD19 is a pan‐B cell marker, one side effect is normal B‐cell depletion. [...]to try and restrict normal B‐cell depletion after CAR‐T cell…”
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Gene Therapy Progress and Prospects: Recombinant adeno-associated virus (rAAV) vectors by FLOTTE, T. R

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Sendai virus vectors. Pushing the envelope in the lung by Flotte, T R

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Stable therapeutic serum levels of human alpha-1 antitrypsin (AAT) after portal vein injection of recombinant adeno-associated virus (rAAV) vectors by SONG, S, EMBURY, J, LAIPIS, P. J, BERNS, K. I, CRAWFORD, J. M, FLOTTE, T. R

“…Previous work from our group showed that recombinant adeno-associated virus (rAAV) vectors mediated long-term secretion of therapeutic serum levels of human…”
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Targeting recombinant adeno-associated virus vectors to enhance gene transfer to pancreatic islets and liver by LOILER, S. A, CONLON, T. J, MUZYCZKA, N, FLOTTE, T. R, SONG, S, TANG, Q, WARRINGTON, K. H, AGARWAL, A, KAPTURCZAK, M, LI, C, RICORDI, C, ATKINSON, M. A

“…Human pancreatic islet cells and hepatocytes represent the two most likely target cells for genetic therapy of type I diabetes. However, limits to the…”
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Pushing the envelope in the lung by Flotte, T R

“…Sendai virus (SeV) is a single-stranded RNA virus that naturally infects the airways of rodents very efciently, causing an acute respiratory illness. In a…”
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IL-10 delivery by AAV5 vector attenuates inflammation in mice with pseudomonas pneumonia by Buff, S M, Yu, H, McCall, J N, Caldwell, S M, Ferkol, T W, Flotte, T R, Virella-Lowell, I L

“…Lung infections with Pseudomonas aeruginosa and other pathogens in cystic fibrosis (CF) cause progressive airway obstruction and tissue damage, the predominant…”
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Mass spectrometry-based proteomic analysis of cutaneous cryoglobulinaemia in formalin-fixed tissues by Shon, W., Dogan, A., Camilleri, M.J., Erickson, L.A., Flotte, T.J.

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Recombinant adeno-associated virus-mediated alpha-1 antitrypsin gene therapy prevents type I diabetes in NOD mice by SONG, S, GOUDY, K, FLOTTE, T. R, CAMPBELL-THOMPSON, M, WASSERFALL, C, SCOTT-JORGENSEN, M, WANG, J, TANG, Q, CRAWFORD, J. M, ELLIS, T. M, ATKINSON, M. A

“…Type I diabetes results from an autoimmune destruction of the insulin-producing pancreatic beta cells. Although the exact immunologic processes underlying this…”
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Mutational Analysis of the Adeno-Associated Virus Type 2 (AAV2) Capsid Gene and Construction of AAV2 Vectors with Altered Tropism by Wu, Pei, Xiao, Wu, Conlon, Thomas, Hughes, Jeffrey, Agbandje-McKenna, Mavis, Ferkol, Thomas, Flotte, Terence, Muzyczka, Nicholas

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Progress and Prospects: Gene Therapy Clinical Trials (Part 1) by ALTON, Eric, BAINBRIDGE, J. W, GREZ, M, THRASHER, A. Z, OTT, M. G, SEGER, R, ALEXANDER, B. L, KAPLITT, M. G, SIMONS, M, YLÄ-HERTTUALA, S, ALL, R. R, GRIESENBACH, U, ALTON, E. W. F. W, FLOTTE, T. R, BRAUN, S, CHENG, S. H, THRASHER, A. J, GASPAR, H. B

“…Over the last two decades gene therapy has moved from preclinical to clinical studies for many diseases ranging from single gene disorders such as cystic…”
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Dermal and conjunctival melanocytic proliferations in diffuse uveal melanocytic proliferation by Pulido, J S, Flotte, T J, Raja, H, Miles, S, Winters, J L, Niles, R, Jaben, E A, Markovic, S N, Davies, J, Kalli, K R, Vile, R G, Garcia, J J, Salomao, D R

“…Aim The goal of this case report is to describe the dermatologic and conjunctival findings in a case of bilateral diffuse uveal melanocytic proliferation…”
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The pros and cons of immunomodulatory IL-10 gene therapy with recombinant AAV in a Cftr -dependent allergy mouse model by Mueller, C, Braag, S A, Martino, A T, Tang, Q, Campbell-Thompson, M, Flotte, T R

“…Cystic fibrosis (CF) patients have decreased levels of lung epithelial interleukin (IL)-10 and increased levels of proinflammatory cytokines (tumor necrosis…”
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Gene therapy for alpha-1 antitrypsin deficiency by Flotte, Terence R, Mueller, Christian

“…Alpha-1 antitrypsin (AAT) deficiency is a common single-gene disorder among Northern Europeans and North Americans. The carrier frequency for the common…”
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Liposomal benzoporphyrin derivative verteporfin photodynamic therapy. Selective treatment of choroidal neovascularization in monkeys by Kramer, M, Miller, J W, Michaud, N, Moulton, R S, Hasan, T, Flotte, T J, Gragoudas, E S

“…The authors have previously shown that photodynamic therapy (PDT) using lipoprotein-delivered benzoporphyrin derivative mono-acid (BPD) effectively closed…”
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Adeno-associated virus vectors for gene therapy by Flotte, T R, Carter, B J

“…Adeno-associated virus type 2 (AAV) is a non-pathogenic DNA virus which has been utilized as a eukaryotic gene transfer vector in vitro and in vivo. AAV…”
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Gene therapy in cystic fibrosis by Flotte, T R, Laube, B L

“…Theoretically, cystic fibrosis transmembrane conductance regulator (CFTR) gene replacement during the neonatal period can decrease morbidity and mortality from…”
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CMV-beta-actin promoter directs higher expression from an adeno-associated viral vector in the liver than the cytomegalovirus or elongation factor 1 alpha promoter and results in therapeutic levels of human factor X in mice by Xu, L, Daly, T, Gao, C, Flotte, T R, Song, S, Byrne, B J, Sands, M S, Parker Ponder, K

“…Although AAV vectors show promise for hepatic gene therapy, the optimal transcriptional regulatory elements have not yet been identified. In this study, we…”
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Detection of microscopic melanoma metastases in sentinel lymph nodes by Yu, Lawrence L., Flotte, Thomas J., Tanabe, Kenneth K., Gadd, Michele A., Cosimi, A. Benedict, Sober, Arthur J., Mihm, Martin C., Duncan, Lyn M.

“…BACKGROUND Sentinel lymph node biopsy following radioisotope labeling is a recently developed, minimally invasive surgical staging procedure used in the…”
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