Search Results - "Flosi, William J"

Enantioselective Synthesis of Antiinfluenza Compound A-315675 by DeGoey, David A, Chen, Hui-Ju, Flosi, William J, Grampovnik, David J, Yeung, Clinton M, Klein, Larry L, Kempf, Dale J

“…Drug discovery efforts at Abbott Laboratories have led to the identification of influenza neuraminidase inhibitor A-315675 (1) as a candidate for development…”
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Characterization of a Novel Human Immunodeficiency Virus Type 1 Protease Inhibitor, A-790742 by Dekhtyar, Tatyana, Ng, Teresa I, Lu, Liangjun, Masse, Sherie, DeGoey, David A, Flosi, William J, Grampovnik, David J, Klein, Larry L, Kempf, Dale J, Molla, Akhteruzzaman

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Water-Soluble Prodrugs of the Human Immunodeficiency Virus Protease Inhibitors Lopinavir and Ritonavir by DeGoey, David A, Grampovnik, David J, Flosi, William J, Marsh, Kennan C, Wang, Xiu C, Klein, Larry L, McDaniel, Keith F, Liu, Yaya, Long, Michelle A, Kati, Warren M, Molla, Akhteruzzaman, Kempf, Dale J

“…We studied the synthesis, cleavage rates, and oral administration of prodrugs of the HIV protease inhibitors (PIs) lopinavir and ritonavir. Phosphate esters…”
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P1-Substituted Symmetry-Based Human Immunodeficiency Virus Protease Inhibitors with Potent Antiviral Activity against Drug-Resistant Viruses by DeGoey, David A, Grampovnik, David J, Chen, Hui-Ju, Flosi, William J, Klein, Larry L, Dekhtyar, Tatyana, Stoll, Vincent, Mamo, Mulugeta, Molla, Akhteruzzaman, Kempf, Dale J

“…Because there is currently no cure for HIV infection, patients must remain on long-term drug therapy, leading to concerns over potential drug side effects and…”
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2-Pyridyl P1′-Substituted Symmetry-Based Human Immunodeficiency Virus Protease Inhibitors (A-792611 and A-790742) with Potential for Convenient Dosing and Reduced Side Effects by DeGoey, David A, Grampovnik, David J, Flentge, Charles A, Flosi, William J, Chen, Hui-ju, Yeung, Clinton M, Randolph, John T, Klein, Larry L, Dekhtyar, Tatyana, Colletti, Lynn, Marsh, Kennan C, Stoll, Vincent, Mamo, Mulugeta, Morfitt, David C, Nguyen, Bach, Schmidt, James M, Swanson, Sue J, Mo, Hongmei, Kati, Warren M, Molla, Akhteruzzaman, Kempf, Dale J

“…A series of symmetry-based HIV protease inhibitors was designed and synthesized. Modification of the core regiochemistry and stereochemistry significantly…”
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Discovery of imidazolidine-2,4-dione-linked HIV protease inhibitors with activity against lopinavir-resistant mutant HIV by Flosi, William J., DeGoey, David A., Grampovnik, David J., Chen, Hui-ju, Klein, Larry L., Dekhtyar, Tatyana, Masse, Sherie, Marsh, Kennan C., Mo, Hong Mei, Kempf, Dale

“…A series of HIV protease inhibitors containing various cyclic structural motifs (Q) which occupy subsite S2 of HIV protease and facilitate the access of P3…”
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Synthesis, antiviral activity, and pharmacokinetic evaluation of P3 pyridylmethyl analogs of oximinoarylsulfonyl HIV-1 protease inhibitors by Randolph, John T., Huang, Peggy P., Flosi, William J., DeGoey, David, Klein, Larry L., Yeung, Clinton M., Flentge, Charles, Sun, Mingua, Zhao, Chen, Dekhtyar, Tatyana, Mo, Hongmei, Colletti, Lynn, Kati, Warren, Marsh, Kennan C., Molla, Akhteruzzaman, Kempf, Dale J.

“…A series of potent inhibitors of HIV-1 protease designed to be equally effective at inhibiting both wild-type virus and a mutant strain of virus (A17) highly…”
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Synthesis of the 3a-(3-Indolyl)-1,2,3,3a,8,8a-hexahydropyrrolo-[2,3-b]indole Core of Leptosins D-F by Crich, David, Fredette, Ewa, J. Flosi, William

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