Search Results - "Flory, James H."

A tutorial on the use of instrumental variables in pharmacoepidemiology by Ertefaie, Ashkan, Small, Dylan S., Flory, James H., Hennessy, Sean

“…Purpose Instrumental variable (IV) methods are used increasingly in pharmacoepidemiology to address unmeasured confounding. In this tutorial, we review the…”
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Reports of Lactic Acidosis Attributed to Metformin, 2015-2018 by Flory, James H, Hennessy, Sean, Bailey, Clifford J, Inzucchi, Silvio E

“…In 2016, the U.S. Food and Drug Administration (FDA) revised metformin's label to permit use in patients with mild-moderate chronic kidney disease. We sought…”
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Do relationships between ambient temperature and serious adverse health outcomes vary among users of different antidiabetes drugs? A retrospective cohort study of US Medicaid beneficiaries with type 2 diabetes by Leonard, Charles E, Bogar, Kacie, Brensinger, Colleen M, Bilker, Warren B, Bell, Michelle L, Flory, James H, Shi, Christopher, Chen, Cheng, Hennessy, Sean

“…Prior studies demonstrate that some untoward clinical outcomes vary by outdoor temperature. This is true of some endpoints common among persons with diabetes,…”
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Comparative Safety of Sulfonylureas and the Risk of Sudden Cardiac Arrest and Ventricular Arrhythmia by Leonard, Charles E, Brensinger, Colleen M, Aquilante, Christina L, Bilker, Warren B, Boudreau, Denise M, Deo, Rajat, Flory, James H, Gagne, Joshua J, Mangaali, Margaret J, Hennessy, Sean

“…To examine the association between individual antidiabetic sulfonylureas and outpatient-originating sudden cardiac arrest and ventricular arrhythmia (SCA/VA)…”
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Characterization, management, and risk factors of hyperglycemia during PI3K or AKT inhibitor treatment by Liu, Dazhi, Weintraub, Michael A., Garcia, Christine, Goncalves, Marcus D., Sisk, Ann Elizabeth, Casas, Alissa, Harding, James J., Harnicar, Stephen, Drilon, Alexander, Jhaveri, Komal, Flory, James H.

“…Purpose The phosphoinositide 3‐kinase (PI3K)/protein kinase B (AKT) pathway controls insulin sensitivity and glucose metabolism. Hyperglycemia is one of the…”
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Treating Alpelisib-Induced Hyperglycemia with Very Low Carbohydrate Diets and Sodium-Glucose Co-Transporter 2 Inhibitors: A Case Series by Blow, Tahj, Hyde, Parker N., Falcone, John N., Neinstein, Aaron, Vasan, Neil, Chitkara, Ritika, Hurd, Maurice A., Sardesai, Sagar, Lustberg, Maryam B., Flory, James H., Volek, Jeff S., Goncalves, Marcus D.

“…Alpelisib is a α-selective phosphatidylinositol 3-kinase (PI3K) inhibitor approved for treatment of postmenopausal women, and men, with hormone receptor…”
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Methadone Use and the Risk of Hypoglycemia for Inpatients With Cancer Pain by Flory, James H., MD, MSCE, Wiesenthal, Alison C., MD, Thaler, Howard T., PhD, Koranteng, Lauren, PharmD, Moryl, Natalie, MD

“…Abstract Context Methadone is an important drug in the management of both cancer-related and non–cancer-related pain and is the main pharmacologic agent used…”
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The risk of sudden cardiac arrest and ventricular arrhythmia with rosiglitazone versus pioglitazone: real-world evidence on thiazolidinedione safety by Leonard, Charles E, Brensinger, Colleen M, Dawwas, Ghadeer K, Deo, Rajat, Bilker, Warren B, Soprano, Samantha E, Dhopeshwarkar, Neil, Flory, James H, Bloomgarden, Zachary T, Gagne, Joshua J, Aquilante, Christina L, Kimmel, Stephen E, Hennessy, Sean

“…The low cost of thiazolidinediones makes them a potentially valuable therapeutic option for the > 300 million economically disadvantaged persons worldwide with…”
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Clinical subphenotypes in COVID-19: derivation, validation, prediction, temporal patterns, and interaction with social determinants of health by Su, Chang, Zhang, Yongkang, Flory, James H., Weiner, Mark G., Kaushal, Rainu, Schenck, Edward J., Wang, Fei

“…The coronavirus disease 2019 (COVID-19) is heterogeneous and our understanding of the biological mechanisms of host response to the viral infection remains…”
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Duplication of the SLIT3 locus on 5q35.1 predisposes to major depressive disorder by Glessner, Joseph T, Wang, Kai, Sleiman, Patrick M A, Zhang, Haitao, Kim, Cecilia E, Flory, James H, Bradfield, Jonathan P, Imielinski, Marcin, Frackelton, Edward C, Qiu, Haijun, Mentch, Frank, Grant, Struan F A, Hakonarson, Hakon

“…Major depressive disorder (MDD) is a common psychiatric and behavioral disorder. To discover novel variants conferring risk to MDD, we conducted a whole-genome…”
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Compared to commercially insured patients, Medicare advantage patients adopt newer diabetes drugs more slowly and adhere to them less by Flory, James H, Li, Jing, Dawwas, Ghadeer K., Leonard, Charles E.

“…ABSTRACT Aims To compare rates of use and adherence for newer versus older second‐line diabetes drug classes in commercially insured, Medicare Advantage and…”
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Chronic Medication Nonadherence and Potentially Preventable Healthcare Utilization and Spending Among Medicare Patients by Zhang, Yongkang, Flory, James H., Bao, Yuhua

“…Background The association between nonadherence to chronic medications and potentially preventable healthcare utilization and spending is largely unknown…”
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Comparative risk of severe hypoglycemia among concomitant users of thiazolidinedione antidiabetic agents and antihyperlipidemics by Leonard, Charles E, Han, Xu, Bilker, Warren B, Flory, James H, Brensinger, Colleen M, Flockhart, David A, Gagne, Joshua J, Cardillo, Serena, Hennessy, Sean

“…Highlights • Concomitant thiazolidinedione + fibrate use was associated with a ∼1.5- to 2.5-fold increased risk of severe hypoglycemia. • This increased risk…”
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Antidiabetic Action of Bezafibrate in a Large Observational Database by Flory, James H, Ellenberg, Susan, Szapary, Philippe O, Strom, Brian L, Hennessy, Sean

“…OBJECTIVE: The purpose of this study was to test the hypothesis that bezafibrate, an approved fibrate, can prevent or delay type 2 diabetes. RESEARCH DESIGN…”
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Metformin use reduction in mild to moderate renal impairment: possible inappropriate curbing of use based on food and drug administration contraindications by Flory, James H, Hennessy, Sean

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Comparative Safety of Sodium-Glucose Cotransporter 2 Inhibitors Versus Dipeptidyl Peptidase 4 Inhibitors and Sulfonylureas on the Risk of Diabetic Ketoacidosis by Dawwas, Ghadeer K, Flory, James H, Hennessy, Sean, Leonard, Charles E, Lewis, James D

“…To assess the association of sodium-glucose cotransporter 2 (SGLT2) inhibitors with diabetic ketoacidosis compared with dipeptidyl peptidase 4 (DPP-4)…”
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The Large Language Model GPT-4 Compared to Endocrinologist Responses on Initial Choice of Antidiabetic Medication under Conditions of Clinical Uncertainty by Flory, James H, Ancker, Jessica S, Kim, Scott Y H, Kuperman, Gilad, Petrov, Aleksandr, Vickers, Andrew

“…To explore how the commercially available large language model (LLM) GPT-4 compares to endocrinologists when addressing medical questions when there is…”
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Effect of Cost and Formulation on Persistence and Adherence to Initial Metformin Therapy for Type 2 Diabetes by Flory, James H, Mushlin, Alvin I

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Prescriber Uncertainty as Opportunity to Improve Care of Type 2 Diabetes with Chronic Kidney Disease: Mixed Methods Study by Flory, James H., Guelce, Dominique, Goytia, Crispin, Li, Jing, Min, Jea Young, Mushlin, Al, Orloff, Jeremy, Mayer, Victoria

“…Background Over 5 million patients in the United States have type 2 diabetes mellitus (T2D) with chronic kidney disease (CKD); antidiabetic drug selection for…”
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Impact of a Provider Tele-mentoring Learning Model on the Care of Medicaid-enrolled Patients With Diabetes by Cantor, Joel C., Chakravarty, Sujoy, Farnham, Jennifer, Nova, Jose, Ahmad, Sana, Flory, James H.

“…Project ECHO (Extension for Community Healthcare Outcomes), a tele-mentoring program for health care providers, has been shown to improve provider-reported…”
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