Search Results - "Floris P.J.T. Rutjes"

Genetic and pharmacological inhibition of vanin-1 activity in animal models of type 2 diabetes by van Diepen, Janna A., Jansen, Patrick A., Ballak, Dov B., Hijmans, Anneke, Rutjes, Floris P.J.T., Tack, Cees J., Netea, Mihai G., Schalkwijk, Joost, Stienstra, Rinke

“…Vanins are enzymes that convert pantetheine to pantothenic acid (vitamin B5). Insights into the function of vanins have evolved lately, indicating vanin-1 to…”
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Pharmacological Inhibition of Vanin Activity Attenuates Transplant Vasculopathy in Rat Aortic Allografts by Wedel, Johannes, Jansen, Patrick A.M, Botman, Peter N.M, Rutjes, Floris P.J.T, Schalkwijk, Joost, Hillebrands, Jan-Luuk

“…BACKGROUNDDevelopment of transplant vasculopathy is a major cause of graft loss and mortality in solid organ transplant recipients. Previous studies in mice…”
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Protective group-free synthesis of 3,4-dihydroxytetrahydrofurans from carbohydrates: formal total synthesis of sphydrofuran by van Kalkeren, Henri A., van Rootselaar, Stefan, Haasjes, Frank S., Rutjes, Floris P.J.T., van Delft, Floris L.

“…[Display omitted] ► Olefination of unprotected carbohydrates with semi-stabilized Wittig reagents. ► Acid-catalyzed intramolecular cyclization of olefinic…”
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Readily Accessible Bicyclononynes for Bioorthogonal Labeling and Three-Dimensional Imaging of Living Cells by Dommerholt, Jan, Schmidt, Samuel, Temming, Rinske, Hendriks, Linda J.A, Rutjes, Floris P.J.T, van Hest, Jan C.M, Lefeber, Dirk J, Friedl, Peter, van Delft, Floris L

“…I can see clearly now: Bicyclo[6.1.0]non‐4‐yne, an easily prepared, symmetrical cycloalkyne, displays excellent reaction kinetics in strain‐promoted…”
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Direct Experimental Characterization of Glycosyl Cations by Infrared Ion Spectroscopy by Elferink, Hidde, Severijnen, Marion E, Martens, Jonathan, Mensink, Rens A, Berden, Giel, Oomens, Jos, Rutjes, Floris P. J. T, Rijs, Anouk M, Boltje, Thomas J

“…Glycosyl cations are crucial intermediates formed during enzymatic and chemical glycosylation. The intrinsic high reactivity and short lifetime of these…”
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Quantitative Trace Analysis of Complex Mixtures Using SABRE Hyperpolarization by Eshuis, Nan, van Weerdenburg, Bram J. A., Feiters, Martin C., Rutjes, Floris P. J. T., Wijmenga, Sybren S., Tessari, Marco

“…Signal amplification by reversible exchange (SABRE) is an emerging nuclear spin hyperpolarization technique that strongly enhances NMR signals of small…”
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Photoracemization‐Based Viedma Ripening of a BINOL Derivative by Belletti, Giuseppe, Tortora, Carola, Mellema, Indradevi D., Tinnemans, Paul, Meekes, Hugo, Rutjes, Floris P. J. T., Tsogoeva, Svetlana B., Vlieg, Elias

“…Viedma ripening is a deracemization process that has been used to deracemize a range of chiral molecules. The method has two major requirements: the compound…”
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The Crystalline Sponge Method in Water by Poel, Wester, Tinnemans, Paul, Duchateau, Alexander L. L., Honing, Maarten, Rutjes, Floris P. J. T., Vlieg, Elias, Gelder, René

“…The crystalline sponge method entails the elucidation of the (absolute) structure of molecules from a solution phase using single‐crystal X‐ray diffraction and…”
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Attrition‐Enhanced Deracemization of the Antimalaria Drug Mefloquine by Engwerda, Anthonius H. J., Maassen, Rick, Tinnemans, Paul, Meekes, Hugo, Rutjes, Floris P. J. T., Vlieg, Elias

“…Mefloquine is an important drug for prevention and treatment of malaria. It is commercially available as a racemic mixture, wherein only one enantiomer is…”
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Untargeted metabolomics and infrared ion spectroscopy identify biomarkers for pyridoxine-dependent epilepsy by Engelke, Udo F.H, van Outersterp, Rianne E, Merx, Jona, van Geenen, Fred A.M.G, van Rooij, Arno, Berden, Giel, Huigen, Marleen C.D.G, Kluijtmans, Leo A.J, Peters, Tessa M.A, Shekaili, Hilal H. Al, Leavitt, Blair R, de Vrieze, Erik, Broekman, Sanne, van Wijk, Erwin, Tseng, Laura A, Kulkarni, Purva, Rutjes, Floris P.J.T, Mecinovic, Jasmin, Struys, Eduard A, Jansen, Laura A, Gospe, Sidney M., Jr, Mercimek-Andrews, Saadet, Hyland, Keith, Willemsen, Michel A.A.P, Bok, Levinus A, van Karnebeek, Clara D.M, Wevers, Ron A, Boltje, Thomas J, Oomens, Jos, Martens, Jonathan, Coene, Karlien L.M

“…Background. Pyridoxine-dependent epilepsy (PDE-ALDH7A1) is an inborn error of lysine catabolism that presents with refractory epilepsy in newborns. Biallelic…”
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Metabolite Identification Using Infrared Ion SpectroscopyNovel Biomarkers for Pyridoxine-Dependent Epilepsy by van Outersterp, Rianne E, Engelke, Udo F.H, Merx, Jona, Berden, Giel, Paul, Mathias, Thomulka, Thomas, Berkessel, Albrecht, Huigen, Marleen C.D.G, Kluijtmans, Leo A.J, Mecinović, Jasmin, Rutjes, Floris P.J.T, van Karnebeek, Clara D.M, Wevers, Ron A, Boltje, Thomas J, Coene, Karlien L.M, Martens, Jonathan, Oomens, Jos

“…Untargeted liquid chromatography–mass spectrometry (LC–MS)-based metabolomics strategies are being increasingly applied in metabolite screening for a wide…”
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Azide: A Unique Dipole for Metal-Free Bioorthogonal Ligations by Debets, Marjoke F, van der Doelen, Christianus W.J, Rutjes, Floris P.J.T, van Delft, Floris L

“…Covalently bound azide on a (small) organic molecule or a (large) biomolecular structure has proven an important handle for bioconjugation. Azides are readily…”
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A New Ir-NHC Catalyst for Signal Amplification by Reversible Exchange in D2O by Spannring, Peter, Reile, Indrek, Emondts, Meike, Schleker, Philipp P. M., Hermkens, Niels K. J., van der Zwaluw, Nick G. J., van Weerdenburg, Bram J. A., Tinnemans, Paul, Tessari, Marco, Blümich, Bernhard, Rutjes, Floris P. J. T., Feiters, Martin C.

“…NMR signal amplification by reversible exchange (SABRE) has been observed for pyridine, methyl nicotinate, N‐methylnicotinamide, and nicotinamide in D2O with…”
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Inline Reaction Monitoring of Amine-Catalyzed Acetylation of Benzyl Alcohol Using a Microfluidic Stripline Nuclear Magnetic Resonance Setup by Oosthoek-de Vries, Anna Jo, Nieuwland, Pieter J, Bart, Jacob, Koch, Kaspar, Janssen, Johannes W. G, van Bentum, P. Jan M, Rutjes, Floris P. J. T, Gardeniers, Han J. G. E, Kentgens, Arno P. M

“…We present an in-depth study of the acetylation of benzyl alcohol in the presence of N,N-diisopropylethylamine (DIPEA) by nuclear magnetic resonance (NMR)…”
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DOSY Analysis of Micromolar Analytes: Resolving Dilute Mixtures by SABRE Hyperpolarization by Reile, Indrek, Aspers, Ruud L. E. G., Tyburn, Jean‐Max, Kempf, James G., Feiters, Martin C., Rutjes, Floris P. J. T., Tessari, Marco

“…DOSY is an NMR spectroscopy technique that resolves resonances according to the analytes’ diffusion coefficients. It has found use in correlating NMR signals…”
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Organophosphorus Catalysis to Bypass Phosphine Oxide Waste by van Kalkeren, Henri A., van Delft, Floris L., Rutjes, Floris P. J. T.

“…The conversion of oxygen‐containing compounds is often achieved by the use of phosphorus reagents. The newly formed phosphine oxide bond delivers the enthalpic…”
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PPAR-alpha dependent regulation of vanin-1 mediates hepatic lipid metabolism by van Diepen, Janna A, Jansen, Patrick A, Ballak, Dov B, Hijmans, Anneke, Hooiveld, Guido J, Rommelaere, Samuel, Galland, Franck, Naquet, Philippe, Rutjes, Floris P.J.T, Mensink, Ronald P, Schrauwen, Patrick, Tack, Cees J, Netea, Mihai G, Kersten, Sander, Schalkwijk, Joost, Stienstra, Rinke

“…Background & Aims Peroxisome proliferator-activated receptor alpha (PPARα) is a key regulator of hepatic fat oxidation that serves as an energy source during…”
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Racemization and Deracemization through Intermolecular Redox Behaviour by Engwerda, Anthonius H. J., Meekes, Hugo, Bickelhaupt, F. Matthias, Rutjes, Floris P. J. T., Vlieg, Elias

“…Chiral molecules exhibiting a quinone and/or hydroquinone moiety are ubiquitous in natural products and small molecule drugs. Herein, we describe a chiral…”
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Chemoenzymatic Synthesis of Sialic Acid Derivatives Using Immobilized N‐Acetylneuraminate Lyase in a Continuous Flow Reactor by Bloemendal, Victor R. L. J., Moons, Sam J., Heming, Jurriaan J. A., Chayoua, Mohamed, Niesink, Olaf, van Hest, Jan C. M., Boltje, Thomas J., Rutjes, Floris P. J. T.

“…The synthesis of N‐acetylneuraminic acid (Neu5Ac) derivatives is drawing more and more attention in glycobiology research because of the important role of…”
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Deracemization of a Racemic Compound by Using Tailor‐Made Additives by Engwerda, Anthonius H. J., van Schayik, Pim, Jagtenberg, Henjo, Meekes, Hugo, Rutjes, Floris P. J. T., Vlieg, Elias

“…Viedma ripening is a process that combines abrasive grinding of a slurry of crystals with solution‐phase racemization, resulting in solid‐phase deracemization…”
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