Search Results - "Florio, Tyler J"

Differential recognition of canonical NF-κB dimers by Importin α3 by Florio, Tyler J., Lokareddy, Ravi K., Yeggoni, Daniel P., Sankhala, Rajeshwer S., Ott, Connor A., Gillilan, Richard E., Cingolani, Gino

“…Nuclear translocation of the p50/p65 heterodimer is essential for NF-κB signaling. In unstimulated cells, p50/p65 is retained by the inhibitor IκBα in the…”
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Decoupling peptide binding from T cell receptor recognition with engineered chimeric MHC-I molecules by Papadaki, Georgia F, Ani, Omar, Florio, Tyler J, Young, Michael C, Danon, Julia N, Sun, Yi, Dersh, Devin, Sgourakis, Nikolaos G

“…Major Histocompatibility Complex class I (MHC-I) molecules display self, viral or aberrant epitopic peptides to T cell receptors (TCRs), which employ…”
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Biophysical analysis of Pseudomonas-phage PaP3 small terminase suggests a mechanism for sequence-specific DNA-binding by lateral interdigitation by Niazi, Marzia, Florio, Tyler J, Yang, Ruoyu, Lokareddy, Ravi K, Swanson, Nicholas A, Gillilan, Richard E, Cingolani, Gino

“…Abstract The genome packaging motor of tailed bacteriophages and herpesviruses is a powerful nanomachine built by several copies of a large (TerL) and a small…”
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Molecular Architecture of the Inositol Phosphatase Siw14 by Florio, Tyler J, Lokareddy, Ravi K, Gillilan, Richard E, Cingolani, Gino

“…Siw14 is a recently discovered inositol phosphatase implicated in suppressing prion propagation in Saccharomyces cerevisiae. In this paper, we used hybrid…”
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Synergy of two low-affinity NLSs determines the high avidity of influenza A virus nucleoprotein NP for human importin α isoforms by Wu, Wei, Sankhala, Rajeshwer S., Florio, Tyler J., Zhou, Lixin, Nguyen, Nhan L. T., Lokareddy, Ravi K., Cingolani, Gino, Panté, Nelly

“…The influenza A virus nucleoprotein (NP) is an essential multifunctional protein that encapsidates the viral genome and functions as an adapter between the…”
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Structural principles of peptide-centric chimeric antigen receptor recognition guide therapeutic expansion by Sun, Yi, Florio, Tyler J, Gupta, Sagar, Young, Michael C, Marshall, Quinlen F, Garfinkle, Samuel E, Papadaki, Georgia F, Truong, Hau V, Mycek, Emily, Li, Peiyao, Farrel, Alvin, Church, Nicole L, Jabar, Shereen, Beasley, Matthew D, Kiefel, Ben R, Yarmarkovich, Mark, Mallik, Leena, Maris, John M, Sgourakis, Nikolaos G

“…Peptide-centric chimeric antigen receptors (PC-CARs) recognize oncoprotein epitopes displayed by cell-surface human leukocyte antigens (HLAs) and offer a…”
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Mechanisms and Regulation of Nf-κB Nuclear Import Through Importin α Isoforms by Florio, Tyler J

“…Nucleocytoplasmic transport is a complex, highly regulated process vital to cell physiology in all eukaryotes. In the ‘classical’ nuclear import pathway,…”
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