Search Results - "Florina, Zakany"

Novel insights into the modulation of the voltage-gated potassium channel KV1.3 activation gating by membrane ceramides by Cs. Szabo, Bence, Szabo, Mate, Nagy, Peter, Varga, Zoltan, Panyi, Gyorgy, Kovacs, Tamas, Zakany, Florina

“…Membrane lipids extensively modulate the activation gating of voltage-gated potassium channels (KV), however, much less is known about the mechanisms of…”
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Statin‐boosted cellular uptake and endosomal escape of penetratin due to reduced membrane dipole potential by Batta, Gyula, Kárpáti, Levente, Henrique, Gabriela Fulaneto, Tóth, Gabriella, Tarapcsák, Szabolcs, Kovacs, Tamas, Zakany, Florina, Mándity, István M., Nagy, Peter

“…Background and Purpose Cell penetrating peptides are promising tools for delivery of cargo into cells, but factors limiting or facilitating their cellular…”
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Cyclodextrins: Only Pharmaceutical Excipients or Full-Fledged Drug Candidates? by Kovacs, Tamas, Nagy, Peter, Panyi, Gyorgy, Szente, Lajos, Varga, Zoltan, Zakany, Florina

“…Cyclodextrins, representing a versatile family of cyclic oligosaccharides, have extensive pharmaceutical applications due to their unique truncated cone-shaped…”
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The Dipole Potential Modifies the Clustering and Ligand Binding Affinity of ErbB Proteins and Their Signaling Efficiency by Kovács, Tamás, Batta, Gyula, Hajdu, Tímea, Szabó, Ágnes, Váradi, Tímea, Zákány, Florina, Csomós, István, Szöllősi, János, Nagy, Peter

“…Although activation of the ErbB family of receptor tyrosine kinases (ErbB1-4) is driven by oligomerization mediated by intermolecular interactions between the…”
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Effect of the Lipid Landscape on the Efficacy of Cell-Penetrating Peptides by Zakany, Florina, Mándity, István M, Varga, Zoltan, Panyi, Gyorgy, Nagy, Peter, Kovacs, Tamas

“…Every cell biological textbook teaches us that the main role of the plasma membrane is to separate cells from their neighborhood to allow for a controlled…”
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Cyclodextrins Exert a Ligand-like Current Inhibitory Effect on the KV1.3 Ion Channel Independent of Membrane Cholesterol Extraction by Kovacs, Tamas, Sohajda, Tamas, Szente, Lajos, Nagy, Peter, Panyi, Gyorgy, Varga, Zoltan, Zakany, Florina

“…Cyclodextrins (CDs) are cyclic oligosaccharides capable of forming water-soluble complexes with a variety of otherwise poorly soluble molecules including…”
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An ω-3, but Not an ω-6 Polyunsaturated Fatty Acid Decreases Membrane Dipole Potential and Stimulates Endo-Lysosomal Escape of Penetratin by Zakany, Florina, Szabo, Mate, Batta, Gyula, Kárpáti, Levente, Mándity, István M, Fülöp, Péter, Varga, Zoltan, Panyi, Gyorgy, Nagy, Peter, Kovacs, Tamas

“…Although the largely positive intramembrane dipole potential (DP) may substantially influence the function of transmembrane proteins, its investigation is…”
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Direct and indirect cholesterol effects on membrane proteins with special focus on potassium channels by Zakany, Florina, Kovacs, Tamas, Panyi, Gyorgy, Varga, Zoltan

“…As described in the literature the interaction between cholesterol and membrane proteins can occur via direct, ligand-like and indirect mechanisms, in which…”
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The dipole potential correlates with lipid raft markers in the plasma membrane of living cells by Kovács, Tamás, Batta, Gyula, Zákány, Florina, Szöllősi, János, Nagy, Peter

“…The dipole potential generating an electric field much stronger than any other type of membrane potential influences a wide array of phenomena, ranging from…”
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It Takes More than Two to Tango: Complex, Hierarchal, and Membrane-Modulated Interactions in the Regulation of Receptor Tyrosine Kinases by Kovacs, Tamas, Zakany, Florina, Nagy, Peter

“…The search for an understanding of how cell fate and motility are regulated is not a purely scientific undertaking, but it can also lead to rationally designed…”
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Chemically diverse antimicrobial peptides induce hyperpolarization of the E. coli membrane by Bhaumik, Kaushik Nath, Spohn, Réka, Dunai, Anett, Daruka, Lejla, Olajos, Gábor, Zákány, Florina, Hetényi, Anasztázia, Pál, Csaba, Martinek, Tamás A.

“…The negative membrane potential within bacterial cells is crucial in various essential cellular processes. Sustaining a hyperpolarised membrane could offer a…”
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Veklury® (remdesivir) formulations inhibit initial membrane‐coupled events of SARS‐CoV‐2 infection due to their sulfobutylether‐β‐cyclodextrin content by Kovacs, Tamas, Kurtan, Kitti, Varga, Zoltan, Nagy, Peter, Panyi, Gyorgy, Zakany, Florina

“…Background and Purpose Despite its contradictory clinical performance, remdesivir (Veklury®) has a pivotal role in COVID‐19 therapy. Possible contributions of…”
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Molecular rearrangements in S6 during slow inactivation in Shaker-IR potassium channels by Szanto, Tibor G, Papp, Ferenc, Zakany, Florina, Varga, Zoltan, Deutsch, Carol, Panyi, Gyorgy

“…Voltage-gated K+ channels have distinct gates that regulate ion flux: the activation gate (A-gate) formed by the bundle crossing of the S6 transmembrane…”
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A synthetic flavonoid derivate in the plasma membrane transforms the voltage‐clamp fluorometry signal of CiHv1 by Pethő, Zoltán, Pajtás, Dávid, Piga, Martina, Magyar, Zsuzsanna, Zakany, Florina, Kovacs, Tamas, Zidar, Nace, Panyi, Gyorgy, Varga, Zoltan, Papp, Ferenc

“…Voltage‐clamp fluorometry (VCF) enables the study of voltage‐sensitive proteins through fluorescent labeling accompanied by ionic current measurements for…”
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Determining the Target of Membrane Sterols on the Gating of Voltage-Gated Potassium Channels using Voltage-Clamp Fluorometry by Florina, Zakany, Papp, Ferenc, Panyi, Gyorgy, Varga, Zoltan

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Characterization of Direct Cyclodextrin Effects on Voltage-Gated Potassium Channels by Zakany, Florina, Kovacs, Tamas, Sohajda, Tamas, Szente, Lajos, Nagy, Peter, Panyi, Gyorgy, Varga, Zoltan

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The activation gate controls steady-state inactivation and recovery from inactivation in Shaker by Szanto, Tibor G, Zakany, Florina, Papp, Ferenc, Varga, Zoltan, Deutsch, Carol J, Panyi, Gyorgy

“…Despite major advances in the structure determination of ion channels, the sequence of molecular rearrangements at negative membrane potentials in…”
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Determining the target of membrane sterols on voltage-gated potassium channels by Zakany, Florina, Pap, Pal, Papp, Ferenc, Kovacs, Tamas, Nagy, Peter, Peter, Maria, Szente, Lajos, Panyi, Gyorgy, Varga, Zoltan

“…Cholesterol, an essential lipid component of cellular plasma membranes, regulates fluidity, mechanical integrity, raft structure and may specifically interact…”
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Novel insights into the modulation of the voltage-gated potassium channel K V 1.3 activation gating by membrane ceramides by Cs Szabo, Bence, Szabo, Mate, Nagy, Peter, Varga, Zoltan, Panyi, Gyorgy, Kovacs, Tamas, Zakany, Florina

“…Membrane lipids extensively modulate the activation gating of voltage-gated potassium channels (K ), however, much less is known about the mechanisms of…”
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Probing the Gating of Kv10.1 Channels by MTS Reagents by Tomczak, Adam P., Papp, Ferenc, Zakany, Florina, Pap, Pal, Pardo, Luis A., Panyi, Gyorgy, Varga, Zoltan

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