Search Results - "Floriano, P."

Key Topics in Molecular Docking for Drug Design by Torres, Pedro H M, Sodero, Ana C R, Jofily, Paula, Silva-Jr, Floriano P

“…Molecular docking has been widely employed as a fast and inexpensive technique in the past decades, both in academic and industrial settings. Although this…”
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Filtering promiscuous compounds in early drug discovery: is it a good idea? by Senger, Mario R., Fraga, Carlos A.M., Dantas, Rafael F., Silva, Floriano P.

“…•Computational filters for unspecific and promiscuous compounds are being disseminated in the literature.•Apparent promiscuity of certain chemical scaffolds…”
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De novo design and bioactivity prediction of SARS-CoV-2 main protease inhibitors using recurrent neural network-based transfer learning by Santana, Marcos V. S., Silva-Jr, Floriano P.

“…The global pandemic of coronavirus disease (COVID-19) caused by SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) created a rush to discover drug…”
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Exploring the DNA binding/cleavage, cellular accumulation and topoisomerase inhibition of 2-hydroxy-3-(aminomethyl)-1,4-naphthoquinone Mannich bases and their platinum(II) complexes by Neves, Amanda P., Pereira, Michelle X.G., Peterson, Erica J., Kipping, Ralph, Vargas, Maria D., Silva-Jr, Floriano P., Carneiro, J. Walkimar M., Farrell, Nicholas P.

“…Several chlorido and amino Pt2+ complexes of 2-hydroxy-3-(aminomethyl)-1,4-naphthoquinone Mannich bases HL exhibiting moderate to high cytotoxicity against…”
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On the three-finger protein domain fold and CD59-like proteins in Schistosoma mansoni by Farias, Leonardo P, Krautz-Peterson, Greice, Tararam, Cibele A, Araujo-Montoya, Bogar O, Fraga, Tatiana R, Rofatto, Henrique K, Silva, Jr, Floriano P, Isaac, Lourdes, Da'dara, Akram A, Wilson, R Alan, Shoemaker, Charles B, Leite, Luciana C C

“…It is believed that schistosomes evade complement-mediated killing by expressing regulatory proteins on their surface. Recently, six homologues of human CD59,…”
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Ethyl Diazoacetate by Aquino, Gabriel A. S., Silva-Jr, Floriano P., Ferreira, Sabrina B.

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Synthesis, Biological Activity, and Molecular Modeling Studies of 1H-1,2,3-Triazole Derivatives of Carbohydrates as α-Glucosidases Inhibitors by Ferreira, Sabrina B, Sodero, Ana C. R, Cardoso, Mariana F. C, Lima, Emerson S, Kaiser, Carlos R, Silva, Floriano P, Ferreira, Vitor F

“…A class of drugs in use for treating type II diabetes mellitus (T2D), typified by the pseudotetrasaccharide acarbose, act by inhibiting the α-glucosidase…”
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Salivary and serum adiponectin and C‐reactive protein levels in acute myocardial infarction related to body mass index and oral health by Ebersole, J. L., Kryscio, R. J., Campbell, C., Kinane, D. F., McDevitt, J., Christodoulides, N., Floriano, P. N., Miller, C. S.

“…Background and Objective Adiponectin is produced by adipose cells and is considered an anti‐inflammatory molecule. In contrast, C‐reactive protein (CRP) has…”
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Schistosomiasis Drug Discovery in the Era of Automation and Artificial Intelligence by Moreira-Filho, José T, Silva, Arthur C, Dantas, Rafael F, Gomes, Barbara F, Souza Neto, Lauro R, Brandao-Neto, Jose, Owens, Raymond J, Furnham, Nicholas, Neves, Bruno J, Silva-Junior, Floriano P, Andrade, Carolina H

“…Schistosomiasis is a parasitic disease caused by trematode worms of the genus and affects over 200 million people worldwide. The control and treatment of this…”
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Discovery of New Anti-Schistosomal Hits by Integration of QSAR-Based Virtual Screening and High Content Screening by Neves, Bruno J, Dantas, Rafael F, Senger, Mario R, Melo-Filho, Cleber C, Valente, Walter C. G, de Almeida, Ana C. M, Rezende-Neto, João M, Lima, Elid F. C, Paveley, Ross, Furnham, Nicholas, Muratov, Eugene, Kamentsky, Lee, Carpenter, Anne E, Braga, Rodolpho C, Silva-Junior, Floriano P, Andrade, Carolina Horta

“…Schistosomiasis is a debilitating neglected tropical disease, caused by flatworms of Schistosoma genus. The treatment relies on a single drug, praziquantel…”
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Editorial: Current approaches in infectious disease drug discovery by Silva-Jr, Floriano P, Panda, Siva S, Andrade, Carolina Horta, Furnham, Nicholas

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Hypoglycaemic activity of Bauhinia holophylla through GSK3-β inhibition and glycogenesis activation by Camaforte, Nathalia Ap. De Paula, Saldanha, Luiz Leonardo, Vareda, Priscilla Maria Ponce, Rezende-Neto, João M., Senger, Mario R., Delgado, Aislan Q., Morgan, Henrique J. N., Violato, Natalia Moretti, Pieroni, Laís Goyos, Dokkedal, Anne Lígia, Silva-Júnior, Floriano P., Bosqueiro, José Roberto

“…Context: Bauhinia L. species, including Bauhinia holophylla (Bong.) Steud. (Fabaceae), have traditionally been used to treat diabetes. Bauhinia is a complex…”
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Spirooxadiazoline‐oxindoles derived from imatinib show antimyeloproliferative potential in K562 cells by Azevedo, Liviane D., Leite, Debora I., Oliveira, Andressa P., Junior, Floriano P. S., Dantas, Rafael F., Bastos, Monica M., Boechat, Nubia, Pimentel, Luiz C. F.

“…Imatinib mesylate was the first representative BCR‐ABL1 tyrosine kinase inhibitor (TKI) class for the treatment of chronic myeloid leukemia. Despite the…”
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Neurological impairment caused by Schistosoma mansoni systemic infection exhibits early features of idiopathic neurodegenerative disease by Gasparotto, Juciano, Senger, Mario Roberto, Telles de Sá Moreira, Emilio, Brum, Pedro Ozorio, Carazza Kessler, Flávio Gabriel, Peixoto, Daniel Oppermann, Panzenhagen, Alana Castro, Ong, Lin Kooi, Campos Soares, Marlene, Reis, Patricia Alves, Schirato, Giuliana Viegas, Góes Valente, Walter César, Araújo Montoya, Bogar Omar, Silva, Floriano P., Fonseca Moreira, José Claudio, Dal-Pizzol, Felipe, Castro-Faria-Neto, Hugo C., Gelain, Daniel Pens

“…Schistosomiasis, a neglected tropical disease caused by trematodes of the Schistosoma genus, affects over 250 million people around the world. This disease has…”
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QSAR-Driven Discovery of Novel Chemical Scaffolds Active against Schistosoma mansoni by Melo-Filho, Cleber C, Dantas, Rafael F, Braga, Rodolpho C, Neves, Bruno J, Senger, Mario R, Valente, Walter C. G, Rezende-Neto, João M, Chaves, Willian T, Muratov, Eugene N, Paveley, Ross A, Furnham, Nicholas, Kamentsky, Lee, Carpenter, Anne E, Silva-Junior, Floriano P, Andrade, Carolina H

“…Schistosomiasis is a neglected tropical disease that affects millions of people worldwide. Thioredoxin glutathione reductase of Schistosoma mansoni (SmTGR) is…”
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Utility of Salivary Biomarkers for Demonstrating Acute Myocardial Infarction by Miller, C.S., Foley, J.D., Floriano, P.N., Christodoulides, N., Ebersole, J.L., Campbell, C.L., Bailey, A.L., Rose, B.G., Kinane, D.F., Novak, M.J., McDevitt, J.T., Ding, X., Kryscio, R.J.

“…The comparative utility of serum and saliva as diagnostic fluids for identifying biomarkers of acute myocardial infarction (AMI) was investigated. The goal was…”
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Data mart construction based on semantic annotation of scientific articles: A case study for the prioritization of drug targets by Teixeira, Marlon Amaro Coelho, Belloze, Kele Teixeira, Cavalcanti, Maria Cláudia, Silva-Junior, Floriano P.

“…•A new design methodology of Data Mart for unstructured data analysis by means of ontologies is proposed.•Design and load of a data mart with focus on gene…”
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Isolation and expression of a hypotensive and anti-platelet acidic phospholipase A2 from Bothrops moojeni snake venom by Silveira, Lucas B., Marchi-Salvador, Daniela P., Santos-Filho, Norival A., Silva, Floriano P., Marcussi, Silvana, Fuly, André L., Nomizo, Auro, da Silva, Saulo L., Stábeli, Rodrigo G., Arantes, Eliane C., Soares, Andreimar M.

“…► BmooPLA2. ► An acidic phospholipase A2. ► Native and recombinant enzyme. ► Anti-platelet and hypotensive properties. ► Potential therapeutic agents. ►…”
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Screening of 1,2-furanonaphthoquinones 1,2,3-1H-triazoles for glycosidases inhibitory activity and free radical scavenging potential: an insight in anticancer activity by Dantas, Rafael F., Senger, Mario R., Cardoso, Mariana F. C., Ferreira, Vitor F., de Souza, Maria Cecília B. V., da Silva, Fernando de C., Silva, Floriano P.

“…In many cancer cells, glycoproteins show abnormal glycosylation patterns which have been associated with tumor initiation, progression, and metastasis. Thus,…”
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Enzymatic and structural characterization of a basic phospholipase A(2) from the sea anemone Condylactis gigantea by Romero, Lazara, Marcussi, Silvana, Marchi-Salvador, Daniela P, Silva, Jr, Floriano P, Fuly, André L, Stábeli, Rodrigo G, da Silva, Saulo L, González, Jorge, Monte, Alberto Del, Soares, Andreimar M

“…This work aimed at the isolation and structural/functional characterization of a phospholipase A(2) (CgPLA(2)) from the extract of the anemone Condylactis…”
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