Search Results - "Florian, R"

The inflammatory pathogenesis of colorectal cancer by Schmitt, Mark, Greten, Florian R.

“…The mutational landscape of colorectal cancer (CRC) does not enable predictions to be made about the survival of patients or their response to therapy…”
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Inflammation and Cancer: Triggers, Mechanisms, and Consequences by Greten, Florian R., Grivennikov, Sergei I.

“…Inflammation predisposes to the development of cancer and promotes all stages of tumorigenesis. Cancer cells, as well as surrounding stromal and inflammatory…”
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Modulating inflammation for cancer therapy by Ritter, Birgit, Greten, Florian R

“…A link between chronic inflammation and development of tumors is well established. Moreover, it has become evident that tumorigenesis is not a cell autonomous…”
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Cell plasticity in epithelial homeostasis and tumorigenesis by Varga, Julia, Greten, Florian R.

“…Greten and co-authors discuss the roles of cell plasticity in epithelial homeostasis, tumour initiation and progression. The adult organism is characterized by…”
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Editorial Comment on “Teaching Hospitals and Textbook Outcomes After Major Urologic Cancer Surgery” by Schroeck, Florian R.

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Inflammation: the incubator of the tumor microenvironment by Denk, Dominic, Greten, Florian R

“…An inflammatory microenvironment, either conferred by an underlying chronic overt or smoldering inflammatory condition constitutes a prerequisite and fuel to…”
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Inflammation and cancer: tissue regeneration gone awry by Pesic, Marina, Greten, Florian R

“…Unresolved chronic inflammation is implicated in all stages of cancer development and an inflammatory tumor microenvironment is considered a hallmark of…”
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Immune cell - produced ROS and their impact on tumor growth and metastasis by Kennel, Kilian B., Greten, Florian R.

“…Reactive oxygen species (ROS) are derivatives of molecular oxygen (O2) involved in various physiological and pathological processes. In immune cells, ROS are…”
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Immunity, Inflammation, and Cancer by Grivennikov, Sergei I., Greten, Florian R., Karin, Michael

“…Inflammatory responses play decisive roles at different stages of tumor development, including initiation, promotion, malignant conversion, invasion, and…”
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Mesenchymal Cells in Colon Cancer by Koliaraki, Vasiliki, Pallangyo, Charles K, Greten, Florian R, Kollias, George

“…Mesenchymal cells in the intestine comprise a variety of cell types of diverse origins, functions, and molecular markers. They provide mechanical and…”
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IKK/NF-[kappa]B and STAT3 pathways: central signalling hubs in inflammation-mediated tumour promotion and metastasis by Bollrath, Julia, Greten, Florian R

“…Our understanding of the molecular mechanisms that link inflammation and cancer has significantly increased in recent years. Here, we analyse genetic evidence…”
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IKK/NF-κB and STAT3 pathways: central signalling hubs in inflammation-mediated tumour promotion and metastasis by Bollrath, Julia, Greten, Florian R.

“…Our understanding of the molecular mechanisms that link inflammation and cancer has significantly increased in recent years. Here, we analyse genetic evidence…”
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Intestinal Tumorigenesis Initiated by Dedifferentiation and Acquisition of Stem-Cell-like Properties by Schwitalla, Sarah, Fingerle, Alexander A., Cammareri, Patrizia, Nebelsiek, Tim, Göktuna, Serkan I., Ziegler, Paul K., Canli, Ozge, Heijmans, Jarom, Huels, David J., Moreaux, Guenievre, Rupec, Rudolf A., Gerhard, Markus, Schmid, Roland, Barker, Nick, Clevers, Hans, Lang, Roland, Neumann, Jens, Kirchner, Thomas, Taketo, Makoto M., van den Brink, Gijs R., Sansom, Owen J., Arkan, Melek C., Greten, Florian R.

“…Cell-type plasticity within a tumor has recently been suggested to cause a bidirectional conversion between tumor-initiating stem cells and nonstem cells…”
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A framework for advancing our understanding of cancer-associated fibroblasts by Sahai, Erik, Astsaturov, Igor, Cukierman, Edna, DeNardo, David G., Egeblad, Mikala, Evans, Ronald M., Fearon, Douglas, Greten, Florian R., Hingorani, Sunil R., Hunter, Tony, Hynes, Richard O., Jain, Rakesh K., Janowitz, Tobias, Jorgensen, Claus, Kimmelman, Alec C., Kolonin, Mikhail G., Maki, Robert G., Powers, R. Scott, Puré, Ellen, Ramirez, Daniel C., Scherz-Shouval, Ruth, Sherman, Mara H., Stewart, Sheila, Tlsty, Thea D., Tuveson, David A., Watt, Fiona M., Weaver, Valerie, Weeraratna, Ashani T., Werb, Zena

“…Cancer-associated fibroblasts (CAFs) are a key component of the tumour microenvironment with diverse functions, including matrix deposition and remodelling,…”
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Therapeutic Ablation of Gain-of-Function Mutant p53 in Colorectal Cancer Inhibits Stat3-Mediated Tumor Growth and Invasion by Schulz-Heddergott, Ramona, Stark, Nadine, Edmunds, Shelley J., Li, Jinyu, Conradi, Lena-Christin, Bohnenberger, Hanibal, Ceteci, Fatih, Greten, Florian R., Dobbelstein, Matthias, Moll, Ute M.

“…Over half of colorectal cancers (CRCs) harbor TP53 missense mutations (mutp53). We show that the most common mutp53 allele R248Q (p53Q) exerts gain of function…”
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IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis by Rokavec, Matjaz, Öner, Meryem Gülfem, Li, Huihui, Jackstadt, Rene, Jiang, Longchang, Lodygin, Dmitri, Kaller, Markus, Horst, David, Ziegler, Paul K, Schwitalla, Sarah, Slotta-Huspenina, Julia, Bader, Franz G, Greten, Florian R, Hermeking, Heiko

“…Members of the miR-34 family are induced by the tumor suppressor p53 and are known to inhibit epithelial-to-mesenchymal transition (EMT) and therefore…”
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Repeated detection of polystyrene microbeads in the Lower Rhine River by Mani, Thomas, Blarer, Pascal, Storck, Florian R., Pittroff, Marco, Wernicke, Theo, Burkhardt-Holm, Patricia

“…Microplastics are emerging pollutants in water bodies worldwide. The environmental entry areas must be studied to localise their sources and develop…”
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Cancer-Associated Fibroblasts in Inflammation and Antitumor Immunity by Kennel, Kilian B, Bozlar, Müge, De Valk, Adalbert F, Greten, Florian R

“…Tumor-associated inflammation (TAI) is a feature of essentially all cancers and can confer both tumor-promoting and -suppressive functions. Cancer-associated…”
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The Relation between Inequality and Intergenerational Class Mobility in 39 Countries by Hertel, Florian R., Groh-Samberg, Olaf

“…We study the relationship between inter-class inequality and intergenerational class mobility across 39 countries. Previous research on the relationship…”
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Glutathione peroxidase 4 prevents necroptosis in mouse erythroid precursors by Canli, Özge, Alankuş, Yasemin B., Grootjans, Sasker, Vegi, Naidu, Hültner, Lothar, Hoppe, Philipp S., Schroeder, Timm, Vandenabeele, Peter, Bornkamm, Georg W., Greten, Florian R.

“…Maintaining cellular redox balance is vital for cell survival and tissue homoeostasis because imbalanced production of reactive oxygen species (ROS) may lead…”
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