Search Results - "Flori Sassano, M."

Evaluation of e-liquid toxicity using an open-source high-throughput screening assay by Sassano, M Flori, Davis, Eric S, Keating, James E, Zorn, Bryan T, Kochar, Tavleen K, Wolfgang, Matthew C, Glish, Gary L, Tarran, Robert

“…The e-liquids used in electronic cigarettes (E-cigs) consist of propylene glycol (PG), vegetable glycerin (VG), nicotine, and chemical additives for flavoring…”
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Chronic E-Cigarette Exposure Alters the Human Bronchial Epithelial Proteome by Ghosh, Arunava, Coakley, Raymond C, Mascenik, Teresa, Rowell, Temperance R, Davis, Eric S, Rogers, Keith, Webster, Megan J, Dang, Hong, Herring, Laura E, Sassano, M Flori, Livraghi-Butrico, Alessandra, Van Buren, Scott K, Graves, Lee M, Herman, Melissa A, Randell, Scott H, Alexis, Neil E, Tarran, Robert

“…E-cigarettes vaporize propylene glycol/vegetable glycerin (PG/VG), nicotine, and flavorings. However, the long-term health effects of exposing lungs to vaped…”
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ELD607 specifically traffics Orai1 to the lysosome leading to inhibition of store operated calcium entry by Goriounova, Alexandra S., Flori Sassano, M., Wrennall, Joe A., Tarran, Robert

“…•We recently developed ELD607, an 11 amino acid peptidomimetic that inhibits store operated Ca2+ entry (SOCE).•Here, we studied ELD607’s mechanism of action:…”
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Acute cigarette smoke or extract exposure rapidly activates TRPA1-mediated calcium influx in primary human airway smooth muscle cells by Lin, JinHeng, Taggart, Michael, Borthwick, Lee, Fisher, Andrew, Brodlie, Malcolm, Sassano, M. Flori, Tarran, Robert, Gray, Michael A.

“…Tobacco smoking is the largest risk factor for developing chronic obstructive pulmonary disease (COPD), and is associated with hyperresponsiveness of airway…”
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A SPLUNC1 Peptidomimetic Inhibits Orai1 and Reduces Inflammation in a Murine Allergic Asthma Model by Wrennall, Joe A, Ahmad, Saira, Worthington, Erin N, Wu, Tongde, Goriounova, Alexandra S, Voeller, Alexis S, Stewart, Ian E, Ghosh, Arunava, Krajewski, Krzysztof, Tilley, Steven L, Hickey, Anthony J, Sassano, M Flori, Tarran, Robert

“…Orai1 is a plasma membrane Ca  channel that mediates store-operated Ca  entry (SOCE) and regulates inflammation. Short palate lung and nasal epithelial clone 1…”
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Cigarette Smoke Exposure Induces Retrograde Trafficking of CFTR to the Endoplasmic Reticulum by Marklew, Abigail J., Patel, Waseema, Moore, Patrick J., Tan, Chong D., Smith, Amanda J., Sassano, M. Flori, Gray, Michael A., Tarran, Robert

“…Chronic obstructive pulmonary disease (COPD), which is most commonly caused by cigarette smoke (CS) exposure, is the third leading cause of death worldwide…”
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E-Liquid Autofluorescence can be used as a Marker of Vaping Deposition and Third-Hand Vape Exposure by Davis, Eric S., Sassano, M. Flori, Goodell, Henry, Tarran, Robert

“…In the past 5 years, e-cigarette use has been increasing rapidly, particularly in youth and young adults. Due to the novelty of e-cigarettes (e-cigs) and…”
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Increases in cytosolic Ca2+ induce dynamin- and calcineurin-dependent internalisation of CFTR by Patel, Waseema, Moore, Patrick J., Sassano, M. Flori, Lopes-Pacheco, Miquéias, Aleksandrov, Andrei A., Amaral, Margarida D., Tarran, Robert, Gray, Michael A.

“…The cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-regulated, apical anion channel that regulates ion and fluid transport in many…”
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SPLUNC1 is a negative regulator of the Orai1 Ca2+ channel by Wu, Tongde, Goriounova, Alexandra S., Worthington, Erin N., Wrennall, Joe A., Ghosh, Arunava, Ahmad, Saira, Flori Sassano, M., Tarran, Robert

“…Orai1 is a ubiquitously‐expressed plasma membrane Ca2+ channel that is involved in store‐operated Ca2+ entry (SOCE): a fundamental biological process that…”
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E-Cigarettes and Cardiopulmonary Health: Review for Clinicians by Neczypor, Evan W., Mears, Matthew J., Ghosh, Arunava, Sassano, M. Flori, Gumina, Richard J., Wold, Loren E., Tarran, Robert

“…Electronic cigarettes (e-cigarettes) are battery powered electronic nicotine delivery systems that use a propylene glycol/vegetable glycerin base to deliver…”
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Lipid-laden Macrophages Are Not Unique to Patients with E-Cigarette or Vaping Product Use-associated Lung Injury by Ghosh, Arunava, Ahmad, Saira, Coakley, Raymond D, Sassano, M Flori, Alexis, Neil E, Tarran, Robert

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A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior by Vardy, Eyal, Robinson, J. Elliott, Li, Chia, Olsen, Reid H.J., DiBerto, Jeffrey F., Giguere, Patrick M., Sassano, Flori M., Huang, Xi-Ping, Zhu, Hu, Urban, Daniel J., White, Kate L., Rittiner, Joseph E., Crowley, Nicole A., Pleil, Kristen E., Mazzone, Christopher M., Mosier, Philip D., Song, Juan, Kash, Thomas L., Malanga, C.J., Krashes, Michael J., Roth, Bryan L.

“…DREADDs are chemogenetic tools widely used to remotely control cellular signaling, neuronal activity, and behavior. Here we used a structure-based approach to…”
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Reactive Oxygen Species, Mitochondrial Membrane Potential, and Cellular Membrane Potential Are Predictors of E-Liquid Induced Cellular Toxicity by Correia-Álvarez, Eva, Keating, James E, Glish, Gary, Tarran, Robert, Sassano, M Flori

“…The use of flavors in electronic cigarettes appeals to adults and never-smoking youth. Consumption has rapidly increased over the last decade, and in the U.S…”
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Specific Inhibition of Orai1-mediated Calcium Signalling Resolves Inflammation and Clears Bacteria in an Acute Respiratory Distress Syndrome Model by Ahmad, Saira, Wrennall, Joe A., Goriounova, Alexandra S., Sekhri, Malika, Iskarpatyoti, Jason A., Ghosh, Arunava, Abdelwahab, Sabri H., Voeller, Alexis, Rai, Mani, Mahida, Rahul Y., Krajewski, Krzysztof, Ignar, Diane M., Greenbaum, Alon, Moran, Timothy P., Tilley, Stephen L., Thickett, David R., Sassano, M. Flori, Tarran, Robert

“…ELD607 is a novel Orai1 antagonist that shows promise in treating acute respiratory distress syndrome (ARDS) caused by bacterial pneumonia. ARDS has a high…”
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N‑Benzyl-5-methoxytryptamines as Potent Serotonin 5‑HT2 Receptor Family Agonists and Comparison with a Series of Phenethylamine Analogues by Nichols, David E, Sassano, M. Flori, Halberstadt, Adam L, Klein, Landon M, Brandt, Simon D, Elliott, Simon P, Fiedler, Wolfgang J

“…A series of N-benzylated-5-methoxytryptamine analogues was prepared and investigated, with special emphasis on substituents in the meta position of the benzyl…”
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Loose ENDs: Electronic Nicotine Delivery Systems and the FDA’s Recent Enforcement Policy by Ahmad, Saira, Sassano, Flori, Tarran, Robert

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SPLUNC1 is a negative regulator of the Orai1 Ca 2+ channel by Wu, Tongde, Goriounova, Alexandra S, Worthington, Erin N, Wrennall, Joe A, Ghosh, Arunava, Ahmad, Saira, Flori Sassano, M, Tarran, Robert

“…Orai1 is a ubiquitously-expressed plasma membrane Ca channel that is involved in store-operated Ca entry (SOCE): a fundamental biological process that…”
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Specific Inhibition of Orai1-mediated Calcium Signalling Resolves Inflammation and Clears Bacteria in an ARDS Model by Ahmad, Saira, Wrennall, Joe A, Goriounova, Alexandra S, Sekhri, Malika, Iskarpatyoti, Jason A, Ghosh, Arunava, Abdelwahab, Sabri H, Voeller, Alexis, Rai, Mani, Mahida, Rahul Y, Krajewski, Krzysztof, Ignar, Diane M, Greenbaum, Alon, Moran, Timothy P, Tilley, Stephen L, Thickett, David R, Sassano, M Flori, Tarran, Robert

“…Acute Respiratory Distress Syndrome (ARDS) has an unacceptably high mortality rate (35%) and is without effective therapy. Orai1 is a Ca channel involved in…”
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Increases in cytosolic Ca 2+ induce dynamin- and calcineurin-dependent internalisation of CFTR by Patel, Waseema, Moore, Patrick J, Sassano, M Flori, Lopes-Pacheco, Miquéias, Aleksandrov, Andrei A, Amaral, Margarida D, Tarran, Robert, Gray, Michael A

“…The cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-regulated, apical anion channel that regulates ion and fluid transport in many…”
Get full text

N -Benzyl-5-methoxytryptamines as Potent Serotonin 5-HT 2 Receptor Family Agonists and Comparison with a Series of Phenethylamine Analogues by Nichols, David E., Sassano, M. Flori, Halberstadt, Adam L., Klein, Landon M., Brandt, Simon D., Elliott, Simon P., Fiedler, Wolfgang J.

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