A maternal low-protein diet results in sex-specific differences in synaptophysin expression and milk fatty acid profiles in neonatal rats

A maternal low-protein diet results in sex-specific differences in synaptophysin expression and milk fatty acid profiles in neonatal rats

The developmental origins of health and disease hypothesis have highlighted the link between early life environment and long-term health outcomes in offspring. For example, maternal protein restriction during pregnancy and lactation can result in adverse metabolic and cognitive outcomes in offspring...

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Published in:Journal of nutritional science (Cambridge) Vol. 13; p. e64
Main Authors: Bello-Medina, Paola C., Díaz-Muñoz, Mauricio, Martín del Campo, Sandra Teresita, Pacheco-Moisés, Fermín Paul, Flores Miguel, Claudia, Cobián Cervantes, Raquel, García Solano, Perla Belén, Navarro-Meza, Mónica
Format: Journal Article
Language:English
Published: Cambridge, UK Cambridge University Press 2024
Subjects:
Animals
Animals, Newborn
Breastfeeding & lactation
Carbohydrates
Chronic illnesses
Developmental Biology
Diet, Protein-Restricted
Fatty acids
Fatty Acids - metabolism
Female
Females
Gestation
Hippocampus
Hippocampus - metabolism
Iodine
Isocaloric low-protein diet (ILPD)
Lactation
Liver
Male
Maternal Nutritional Physiological Phenomena
Metabolic markers
Metabolism
Milk - chemistry
Molybdenum
Mothers
Neurosciences
Oxidative Stress
Postpartum period
Potassium
Pregnancy
Proteins
Rats
Rats, Wistar
Selenium
Sex Factors
Sodium
Synaptogenesis
Synaptophysin - metabolism
Vitamin E
United States > US
Gestation
Metabolic markers
Lactation
Synaptogenesis
Hippocampus
Isocaloric low-protein diet (ILPD)
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Summary:The developmental origins of health and disease hypothesis have highlighted the link between early life environment and long-term health outcomes in offspring. For example, maternal protein restriction during pregnancy and lactation can result in adverse metabolic and cognitive outcomes in offspring postnatal. Hence, in the present study, we assess whether an isocaloric low-protein diet (ILPD) affects the fatty acid profile in breast milk, the hippocampal synaptophysin (Syn) ratio, and the oxidative stress markers in the neonatal stage of male and female offspring. The aim of this work was to assess the effect of an ILPD on the fatty acid profile in breast milk, quantified the hippocampal synaptophysin (Syn) ratio and oxidative stress markers in neonatal stage of male and female offspring. Female Wistar rats were fed with either a control diet or an ILPD during gestation to day 10 of lactation. Oxidative stress markers were assessed in serum and liver. All quantifications were done at postnatal day 10. The results showed: ILPD led to decreases of 38.5% and 17.4% in breast milk volume and polyunsaturated fatty acids content. Significant decreases of hippocampal Syn ratio in male offspring (decreases of 98% in hippocampal CA1 pyramidal and CA1 oriens, 83%, stratum pyramidal in CA3, 80%, stratum lucidum in CA3, and 81% stratum oriens in CA3). Male offspring showed an increase in pro-oxidant status in serum and liver. Thus, the data suggest that male offspring are more vulnerable than females to an ILPD during gestation and lactation.
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ISSN:2048-6790
2048-6790
DOI:10.1017/jns.2024.46