Search Results - "Flores‐Díaz, Marietta"

Bacterial Sphingomyelinases and Phospholipases as Virulence Factors by Flores-Díaz, Marietta, Monturiol-Gross, Laura, Naylor, Claire, Alape-Girón, Alberto, Flieger, Antje

“…Bacterial sphingomyelinases and phospholipases are a heterogeneous group of esterases which are usually surface associated or secreted by a wide variety of…”
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Biological models in multiple sclerosis by Sanabria‐Castro, Alfredo, Flores‐Díaz, Marietta, Alape‐Girón, Alberto

“…Considering the etiology of multiple sclerosis (MS) is still unknown, experimental models resembling specific aspects of this immune‐mediated demyelinating…”
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Snake Venomics of the Lancehead Pitviper Bothrops asper: Geographic, Individual, and Ontogenetic Variations by Alape-Girón, Alberto, Sanz, Libia, Escolano, José, Flores-Díaz, Marietta, Madrigal, Marvin, Sasa, Mahmood, Calvete, Juan J

“…We report the comparative proteomic characterization of the venoms of adult and newborn specimens of the lancehead pitviper Bothrops asper from two…”
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Snake Venomics of the Central American Rattlesnake Crotalus simus and the South American Crotalus durissus Complex Points to Neurotoxicity as an Adaptive Paedomorphic Trend along Crotalus Dispersal in South America by Calvete, Juan J, Sanz, Libia, Cid, Pedro, de la Torre, Pilar, Flores-Díaz, Marietta, Dos Santos, M. Cristina, Borges, Adolfo, Bremo, Adolfo, Angulo, Yamileth, Lomonte, Bruno, Alape-Girón, Alberto, Gutiérrez, José María

“…We report a comparative venomic and antivenomic characterization of the venoms of newborn and adult specimens of the Central American rattlesnake, Crotalus…”
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Clostridium perfringens phospholipase C, an archetypal bacterial virulence factor, induces the formation of extracellular traps by human neutrophils by Badilla-Vargas, Lisa, Pereira, Reynaldo, Molina-Mora, José Arturo, Alape-Girón, Alberto, Flores-Díaz, Marietta

“…Neutrophil extracellular traps (NETs) are networks of DNA and various microbicidal proteins released to kill invading microorganisms and prevent their…”
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Bacterial phospholipases C with dual activity: phosphatidylcholinesterase and sphingomyelinase by Monturiol‐Gross, Laura, Villalta‐Romero, Fabian, Flores‐Díaz, Marietta, Alape‐Girón, Alberto

“…Bacterial phospholipases and sphingomyelinases are lipolytic esterases that are structurally and evolutionarily heterogeneous. These enzymes play crucial roles…”
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Snake venomics and antivenomics: Proteomic tools in the design and control of antivenoms for the treatment of snakebite envenoming by Gutiérrez, José María, Lomonte, Bruno, León, Guillermo, Alape-Girón, Alberto, Flores-Díaz, Marietta, Sanz, Libia, Angulo, Yamileth, Calvete, Juan J.

“…Snakebite envenoming represents a neglected tropical disease that has a heavy public health impact, particularly in Asia, Africa and Latin America. A global…”
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Cross-reactivity, antivenomics, and neutralization of toxic activities of Lachesis venoms by polyspecific and monospecific antivenoms by Madrigal, Marvin, Pla, Davinia, Sanz, Libia, Barboza, Elexandra, Arroyo-Portilla, Cynthia, Corrêa-Netto, Carlos, Gutiérrez, José María, Alape-Girón, Alberto, Flores-Díaz, Marietta, Calvete, Juan J

“…Bothrops, Crotalus and Lachesis represent the most medically relevant genera of pitvipers in Central and South America. Similarity in venom phenotype and…”
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Clostridium perfringens phospholipase C induced ROS production and cytotoxicity require PKC, MEK1 and NFκB activation by Monturiol-Gross, Laura, Flores-Díaz, Marietta, Pineda-Padilla, Maria Jose, Castro-Castro, Ana Cristina, Alape-Giron, Alberto

“…Clostridium perfringens phospholipase C (CpPLC), also called α-toxin, is the most toxic extracellular enzyme produced by this bacteria and is essential for…”
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Impact of Regional Variation in Bothrops asper Snake Venom on the Design of Antivenoms: Integrating Antivenomics and Neutralization Approaches by Gutiérrez, José María, Sanz, Libia, Flores-Díaz, Marietta, Figueroa, Lucía, Madrigal, Marvin, Herrera, María, Villalta, Mauren, León, Guillermo, Estrada, Ricardo, Borges, Adolfo, Alape-Girón, Alberto, Calvete, Juan J

“…Intraspecific snake venom variations have implications in the preparation of venom pools for the generation of antivenoms. The impact of such variation in the…”
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Internalization of Clostridium perfringens α‐toxin leads to ERK activation and is involved on its cytotoxic effect by Monturiol‐Gross, Laura, Flores‐Díaz, Marietta, Campos‐Rodríguez, Diana, Mora, Rodrigo, Rodríguez‐Vega, Mariela, Marks, David L., Alape‐Girón, Alberto

“…Summary Clostridium perfringens phospholipase C (CpPLC), also called α‐toxin, plays a key role in the pathogenesis of gas gangrene. CpPLC may lead to cell…”
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NanI and NanJ Sialidases of Clostridium perfringens Are Not Essential for Virulence by Chiarezza, Martina, Lyras, Dena, Pidot, Sacha J, Flores-Díaz, Marietta, Awad, Milena M, Kennedy, Catherine L, Cordner, Leanne M, Phumoonna, Tongted, Poon, Rachael, Hughes, Meredith L, Emmins, John J, Alape-Girón, Alberto, Rood, Julian I

“…The essential toxin in Clostridium perfringens-mediated gas gangrene or clostridial myonecrosis is alpha-toxin, although other toxins and extracellular enzymes…”
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High Efficacy of Therapeutic Equine Hyperimmune Antibodies Against SARS-CoV-2 Variants of Concern by Moreira-Soto, Andres, Arguedas, Mauricio, Brenes, Hebleen, Buján, Willem, Corrales-Aguilar, Eugenia, Díaz, Cecilia, Echeverri, Ann, Flores-Díaz, Marietta, Gómez, Aarón, Hernández, Andrés, Herrera, María, León, Guillermo, Macaya, Román, Kühne, Arne, Molina-Mora, José Arturo, Mora, Javier, Sanabria, Alfredo, Sánchez, Andrés, Sánchez, Laura, Segura, Álvaro, Segura, Eduardo, Solano, Daniela, Soto, Claudio, Stynoski, Jennifer L., Vargas, Mariángela, Villalta, Mauren, Reusken, Chantal B. E. M., Drosten, Christian, Gutiérrez, José María, Alape-Girón, Alberto, Drexler, Jan Felix

“…SARS-CoV-2 variants of concern show reduced neutralization by vaccine-induced and therapeutic monoclonal antibodies; therefore, treatment alternatives are…”
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Heterologous Hyperimmune Polyclonal Antibodies Against SARS-CoV-2: A Broad Coverage, Affordable, and Scalable Potential Immunotherapy for COVID-19 by Alape-Girón, Alberto, Moreira-Soto, Andrés, Arguedas, Mauricio, Brenes, Hebleen, Buján, Willem, Corrales-Aguilar, Eugenia, Díaz, Cecilia, Echeverri, Ann, Flores-Díaz, Marietta, Gómez, Aarón, Hernández, Andrés, Herrera, María, León, Guillermo, Macaya, Román, Molina-Mora, José Arturo, Mora, Javier, Narayanan, Aarthi, Sanabria, Alfredo, Sánchez, Andrés, Sánchez, Laura, Segura, Álvaro, Segura, Eduardo, Solano, Daniela, Soto, Claudio, Stynoski, Jennifer L, Vargas, Mariángela, Villalta, Mauren, Drexler, Jan Felix, Gutiérrez, José María

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Deficient Skeletal Muscle Regeneration after Injury Induced by a Clostridium perfringens Strain Associated with Gas Gangrene by Zúñiga-Pereira, Ana Mariel, Santamaría, Carlos, Gutierrez, José María, Alape-Girón, Alberto, Flores-Díaz, Marietta

“…Gas gangrene, or clostridial myonecrosis, is usually caused by and may occur spontaneously in association with diabetes mellitus, peripheral vascular disease,…”
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Snake venomics across genus Lachesis. Ontogenetic changes in the venom composition of Lachesis stenophrys and comparative proteomics of the venoms of adult Lachesis melanocephala and Lachesis acrochorda by Madrigal, Marvin, Sanz, Libia, Flores-Díaz, Marietta, Sasa, Mahmood, Núñez, Vitelbina, Alape-Girón, Alberto, Calvete, Juan J.

“…We report the proteomic analysis of ontogenetic changes in venom composition of the Central American bushmaster, Lachesis stenophrys, and the characterization…”
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Snake venomics of Lachesis muta rhombeata and genus-wide antivenomics assessment of the paraspecific immunoreactivity of two antivenoms evidence the high compositional and immunological conservation across Lachesis by Pla, Davinia, Sanz, Libia, Molina-Sánchez, Pedro, Zorita, Virginia, Madrigal, Marvin, Flores-Díaz, Marietta, Alape-Girón, Alberto, Núñez, Vitelbina, Andrés, Vicente, Gutiérrez, José María, Calvete, Juan J.

“…We report the proteomic analysis of the Atlantic bushmaster, Lachesis muta rhombeata, from Brazil. Along with previous characterization of the venom proteomes…”
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Profiling the venom gland transcriptomes of Costa Rican snakes by 454 pyrosequencing by Durban, Jordi, Juárez, Paula, Angulo, Yamileth, Lomonte, Bruno, Flores-Diaz, Marietta, Alape-Girón, Alberto, Sasa, Mahmood, Sanz, Libia, Gutiérrez, José M, Dopazo, Joaquín, Conesa, Ana, Calvete, Juan J

“…A long term research goal of venomics, of applied importance for improving current antivenom therapy, but also for drug discovery, is to understand the…”
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Reactive Oxygen Species and the MEK/ERK Pathway Are Involved in the Toxicity of Clostridium perfringens α-Toxin, a Prototype Bacterial Phospholipase C by Monturiol-Gross, Laura, Flores-Díaz, Marietta, Araya-Castillo, Cindy, Pineda-Padilla, María-José, Clark, Graeme C., Titball, Richard W., Alape-Girón, Alberto

“…Clostridium perfringens, the most broadly distributed pathogen in nature, produces a prototype phospholipase C, also called α-toxin, which plays a key role in…”
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Effects of bilayer composition and physical properties on the phospholipase C and sphingomyelinase activities of Clostridium perfringens α-toxin by Urbina, Patricia, Flores-Díaz, Marietta, Alape-Girón, Alberto, Alonso, Alicia, Goñi, Félix M.

“…α-Toxin, a major determinant of Clostridium perfringens toxicity, exhibits both phospholipase C and sphingomyelinase activities. Our studies with large…”
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