Search Results - "Flores, Samuel C."

Phosphorylation by PINK1 releases the UBL domain and initializes the conformational opening of the E3 ubiquitin ligase Parkin by Caulfield, Thomas R, Fiesel, Fabienne C, Moussaud-Lamodière, Elisabeth L, Dourado, Daniel F A R, Flores, Samuel C, Springer, Wolfdieter

“…Loss-of-function mutations in PINK1 or PARKIN are the most common causes of autosomal recessive Parkinson's disease. Both gene products, the Ser/Thr kinase…”
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Structural and Functional Impact of Parkinson Disease-Associated Mutations in the E3 Ubiquitin Ligase Parkin by Fiesel, Fabienne C., Caulfield, Thomas R., Moussaud-Lamodière, Elisabeth L., Ogaki, Kotaro, Dourado, Daniel F.A.R., Flores, Samuel C., Ross, Owen A., Springer, Wolfdieter

“…ABSTRACT Mutations in the PARKIN/PARK2 gene that result in loss‐of‐function of the encoded, neuroprotective E3 ubiquitin ligase Parkin cause recessive,…”
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FlexOracle: predicting flexible hinges by identification of stable domains by Flores, Samuel C, Gerstein, Mark B

“…Protein motions play an essential role in catalysis and protein-ligand interactions, but are difficult to observe directly. A substantial fraction of protein…”
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Predicting protein ligand binding motions with the conformation explorer by Flores, Samuel C, Gerstein, Mark B

“…Knowledge of the structure of proteins bound to known or potential ligands is crucial for biological understanding and drug design. Often the 3D structure of…”
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Hinge Atlas: relating protein sequence to sites of structural flexibility by Flores, Samuel C, Lu, Long J, Yang, Julie, Carriero, Nicholas, Gerstein, Mark B

“…Relating features of protein sequences to structural hinges is important for identifying domain boundaries, understanding structure-function relationships, and…”
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HingeMaster: Normal mode hinge prediction approach and integration of complementary predictors by Flores, Samuel C., Keating, Kevin S., Painter, Jay, Morcos, Faruck, Nguyen, Khang, Merritt, Ethan A., Kuhn, Leslie A., Gerstein, Mark B.

“…Protein motion is often the link between structure and function and a substantial fraction of proteins move through a domain hinge bending mechanism…”
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Strategies for articulated multibody-based adaptive coarse grain simulation of RNA by Poursina, Mohammad, Bhalerao, Kishor D, Flores, Samuel C, Anderson, Kurt S, Laederach, Alain

“…Efficient modeling approaches are necessary to accurately predict large-scale structural behavior of biomolecular systems like RNA (ribonucleic acid)…”
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Predicting RNA structure by multiple template homology modeling by Flores, Samuel C, Wan, Yaqi, Russell, Rick, Altman, Russ B

“…Despite the importance of 3D structure to understand the myriad functions of RNAs in cells, most RNA molecules remain out of reach of crystallographic and NMR…”
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StoneHinge: Hinge prediction by network analysis of individual protein structures by Keating, Kevin S., Flores, Samuel C., Gerstein, Mark B., Kuhn, Leslie A.

“…Hinge motions are important for molecular recognition, and knowledge of their location can guide the sampling of protein conformations for docking. Predicting…”
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Multiscale modeling of macromolecular biosystems by Flores, Samuel C, Bernauer, Julie, Shin, Seokmin, Zhou, Ruhong, Huang, Xuhui

“…In this article, we review the recent progress in multiresolution modeling of structure and dynamics of protein, RNA and their complexes. Many approaches using…”
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Dissecting the Mechanism of Epac Activation via Hydrogen−Deuterium Exchange FT-IR and Structural Modeling by Yu, Shaoning, Fan, Fenghui, Flores, Samuel C, Mei, Fang, Cheng, Xiaodong

“…Exchange proteins directly activated by cAMP (Epac) make up a family of cAMP binding domain-containing proteins that play important roles in mediating the…”
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Model Study of Coherent-Control of the Femtosecond Primary Event of Vision by Flores, Samuel C, Batista, Victor S

“…A bichirped coherent-control scenario is introduced and implemented in a model study of coherent-control of the cis/trans photoisomerization of the retinal…”
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Elucidating Ribosomal Translocation with Internal Coordinate Flexible Fitting by Flores, Samuel C.

“…Determining conformational changes of large macromolecules is challenging experimentally and computationally. The ribosome has been observed…”
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Investigating Ribosome Conformations with Multi-Resolution Modeling by Tek, Alex, Chen, Yang, Selmer, Maria, Flores, Samuel C.

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Structural and Functional Impact of Parkinson Disease-Associated Mutations in the E3 Ubiquitin Ligase Parkin: HUMAN MUTATION by Fiesel, Fabienne C., Caulfield, Thomas R., Moussaud-Lamodière, Elisabeth L., Ogaki, Kotaro, Dourado, Daniel F.A.R., Flores, Samuel C., Ross, Owen A., Springer, Wolfdieter

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Phosphorylation by PINK1 Releases the UBL Domain and Initializes the Conformational Opening of the E3 Ubiquitin Ligase Parkin: e1003935 by Caulfield, Thomas R, Fiesel, Fabienne C, Moussaud-Lamodière, Elisabeth L, Dourado, F AR, Flores, Samuel C, Springer, Wolfdieter

“…Loss-of-function mutations in PINK1 or PARKIN are the most common causes of autosomal recessive Parkinson's disease. Both gene products, the Ser/Thr kinase…”
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Multiscale modeling of macromolecular biosystems: Current Progress in Bioinformatics 2012 by FLORES, Samuel C, BERNAUER, Julie, SHIN, Seokmin, RUHONG ZHOU, XUHUI HUANG

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Dissecting the mechanism of Epac activation by hydrogen/deuterium exchange FT-IR and structural modeling by Yu, Shaoning, Fan, Fenghui, Flores, Samuel C., Mei, Fang, Cheng, Xiaodong

“…Exchange proteins directly activated by cAMP (Epac) is a family of cAMP-binding domain containing proteins that play important roles in mediating the effects…”
Get full text