Search Results - "Flores, Paola Cruz"
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Extracellular signals induce dynamic ER remodeling through αTAT1-dependent microtubule acetylation
Published in Neoplasia (New York, N.Y.) (01-07-2024)“…Dynamic changes in the endoplasmic reticulum (ER) morphology are central to maintaining cellular homeostasis. Microtubules (MT) facilitate the continuous…”
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βIV-spectrin as a stalk cell-intrinsic regulator of VEGF signaling
Published in Nature communications (14-03-2022)“…Defective angiogenesis underlies over 50 malignant, ischemic and inflammatory disorders yet long-term therapeutic applications inevitably fail, thus…”
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Beta IV spectrin inhibits the metastatic growth of melanoma by suppressing VEGFR2‐driven tumor angiogenesis
Published in Cancer medicine (Malden, MA) (01-09-2023)“…Background Tumor‐associated angiogenesis mediates the growth and metastasis of most solid cancers. Targeted therapies of the VEGF pathways can effectively…”
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Phosphoproteomic profiling identifies DNMT1 as a key substrate of beta IV spectrin-dependent ERK/MAPK signaling in suppressing angiogenesis
Published in Biochemical and biophysical research communications (04-06-2024)“…βIV-spectrin is a membrane-associated cytoskeletal protein that maintains the structural stability of cell membranes and integral proteins such as ion channels…”
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Implications of Transforming Growth Factor Beta Activating Kinase I (TAK1) Induced Phosphorylation on Organelle Remodeling in Human Pathologies
Published 01-01-2024“…Transforming growth factor β, (TGF-β) signaling is a broadly studied field and affects every aspect of mammalian physiology starting from embryogenesis to…”
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Dissertation -
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Endothelial tip/stalk cell selection requires BMP9-induced β IV -spectrin expression during sprouting angiogenesis
Published in Molecular biology of the cell (01-06-2023)“…β -Spectrin is a membrane cytoskeletal protein with specialized roles in the nervous system and heart. Recent evidence also indicates a fundamental role for β…”
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Journal Article -
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EPDR1 is a noncanonical effector of insulin-mediated angiogenesis regulated by an endothelial-specific TGF-β receptor complex
Published in The Journal of biological chemistry (01-09-2022)“…Insulin signaling in blood vessels primarily functions to stimulate angiogenesis and maintain vascular homeostasis through the canonical PI3K and MAPK…”
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Regulation of mitochondrial fission by GIPC-mediated Drp1 retrograde transport
Published in Molecular biology of the cell (01-01-2022)“…Dynamin-related protein 1 (Drp1) is a key regulator of mitochondrial fission, a large cytoplasmic GTPase recruited to the mitochondrial surface via…”
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Antioxidant capacity, proximate composition, and lipid constituents of Aloe vera flowers
Published in Journal of applied research on medicinal and aromatic plants (01-09-2018)“…[Display omitted] •Complete proximate analysis of Aloe vera flowers to obtain nutritional information.•Antioxidant activity of aloe flower by DPPH scavenging…”
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An HPLC Procedure for the Quantification of Aloin in Latex and Gel from Aloe barbadensis Leaves
Published in Journal of chromatographic science (01-03-2017)“…Aloin is an anthraquinone-C-glycoside present in Aloe vera. This compound is extremely variable among different species and highly depends on the growing…”
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Journal Article -
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Análisis de la Oferta Académica en Ambato y su Pertinencia para el Desarrollo Regional
Published in Sociedad & Tecnología (01-11-2024)“…Este artículo examina la oferta académica en la ciudad de Ambato, provincia de Tungurahua, Ecuador, y su pertinencia para el desarrollo socioeconómico…”
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Journal Article