Search Results - "Flores, Maria Vega"

Infection-Responsive Expansion of the Hematopoietic Stem and Progenitor Cell Compartment in Zebrafish Is Dependent upon Inducible Nitric Oxide by Hall, Christopher J., Flores, Maria Vega, Oehlers, Stefan H., Sanderson, Leslie E., Lam, Enid Y., Crosier, Kathryn E., Crosier, Philip S.

“…Hematopoietic stem cells (HSCs) are rare multipotent cells that contribute to all blood lineages. During inflammatory stress, hematopoietic stem and progenitor…”
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Zebrafish heat shock protein a4 genes in the intestinal epithelium are up-regulated during inflammation by Crawford, Katie C., Vega Flores, Maria, Oehlers, Stefan H., Hall, Christopher J., Crosier, Kathryn E., Crosier, Philip S.

“…A number of heat shock proteins (HSPs), including Hsp70 and Hsp110, function as molecular chaperones within intestinal epithelial cells that line the mammalian…”
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Runx1 is required for zebrafish blood and vessel development and expression of a human RUNX1-CBF2T1 transgene advances a model for studies of leukemogenesis by Kalev-Zylinska, Maggie L, Horsfield, Julia A, Flores, Maria Vega C, Postlethwait, John H, Vitas, Maria R, Baas, Andrea M, Crosier, Philip S, Crosier, Kathryn E

“…RUNX1/AML1/CBFA2 is essential for definitive hematopoiesis, and chromosomal translocations affecting RUNX1 are frequently involved in human leukemias…”
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Osteogenic transcription factor Runx2 is a maternal determinant of dorsoventral patterning in zebrafish by Flores, Maria Vega C, Crosier, Kathryn E, Crosier, Philip S, Lam, Enid Yi Ni

“…The maternal genome greatly influences vertebrate embryogenesis before activation of zygotic transcription. Dorsoventral patterning is initiated by maternal…”
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Immunoresponsive Gene 1 Augments Bactericidal Activity of Macrophage-Lineage Cells by Regulating β-Oxidation-Dependent Mitochondrial ROS Production by Hall, Christopher J., Boyle, Rachel H., Astin, Jonathan W., Flores, Maria Vega, Oehlers, Stefan H., Sanderson, Leslie E., Ellett, Felix, Lieschke, Graham J., Crosier, Kathryn E., Crosier, Philip S.

“…Evidence suggests the bactericidal activity of mitochondria-derived reactive oxygen species (mROS) directly contributes to killing phagocytozed bacteria…”
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The zebrafish lysozyme C promoter drives myeloid-specific expression in transgenic fish by Hall, Chris, Flores, Maria Vega, Storm, Thilo, Crosier, Kathy, Crosier, Phil

“…How different immune cell compartments contribute to a successful immune response is central to fully understanding the mechanisms behind normal processes such…”
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Live imaging of Runx1 expression in the dorsal aorta tracks the emergence of blood progenitors from endothelial cells by Lam, Enid Yi Ni, Hall, Christopher J., Crosier, Philip S., Crosier, Kathryn E., Flores, Maria Vega

“…Blood cells of an adult vertebrate are continuously generated by hematopoietic stem cells (HSCs) that originate during embryonic life within the…”
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A whole animal chemical screen approach to identify modifiers of intestinal neutrophilic inflammation by Oehlers, Stefan H., Flores, Maria Vega, Hall, Christopher J., Wang, Liuyang, Ko, Dennis C., Crosier, Kathryn E., Crosier, Philip S.

“…By performing two high‐content small molecule screens on dextran sodium sulfate‐ and trinitrobenzene sulfonic acid‐induced zebrafish enterocolitis models of…”
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The inflammatory bowel disease (IBD) susceptibility genes NOD1 and NOD2 have conserved anti-bacterial roles in zebrafish by Oehlers, Stefan H, Flores, Maria Vega, Hall, Chris J, Swift, Simon, Crosier, Kathryn E, Crosier, Philip S

“…Inflammatory bowel disease (IBD), in the form of Crohn's disease (CD) or ulcerative colitis (UC), is a debilitating chronic immune disorder of the intestine. A…”
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Retinoic acid suppresses intestinal mucus production and exacerbates experimental enterocolitis by Oehlers, Stefan H, Flores, Maria Vega, Hall, Christopher J, Crosier, Kathryn E, Crosier, Philip S

“…Exposure to retinoids for the treatment of acne has been linked to the etiology of inflammatory bowel disease (IBD). The intestinal mucus layer is an important…”
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Transgenic zebrafish reporter lines reveal conserved Toll-like receptor signaling potential in embryonic myeloid leukocytes and adult immune cell lineages by Hall, Chris, Flores, Maria Vega, Chien, Annie, Davidson, Alan, Crosier, Kathryn, Crosier, Phil

“…The immune response of a host to an invading pathogen is dependent on the capacity of its immune cell compartment to recognize highly conserved pathogen…”
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Chemically induced intestinal damage models in zebrafish larvae by Oehlers, Stefan H, Flores, Maria Vega, Hall, Christopher J, Okuda, Kazuhide S, Sison, John Oliver, Crosier, Kathryn E, Crosier, Philip S

“…Several intestinal damage models have been developed using zebrafish, with the aim of recapitulating aspects of human inflammatory bowel disease (IBD). These…”
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A hierarchy of Runx transcription factors modulate the onset of chondrogenesis in craniofacial endochondral bones in zebrafish by Flores, Maria Vega, Lam, Enid Yi Ni, Crosier, Philip, Crosier, Kathryn

“…The Runx (runt‐related) family of transcription factors are important regulators of cell fate decisions in early embryonic development, and in differentiation…”
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Visualization of embryonic lymphangiogenesis advances the use of the zebrafish model for research in cancer and lymphatic pathologies by Flores, Maria Vega, Hall, Christopher J., Crosier, Kathryn E., Crosier, Philip S.

“…Lymphangiogenesis induced during tumor growth contributes to metastasis. Genetic and chemical screens using the zebrafish model have the potential to enhance…”
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Topographical distribution of antimicrobial genes in the zebrafish intestine by Oehlers, Stefan H., Flores, Maria Vega, Chen, Tony, Hall, Chris J., Crosier, Kathryn E., Crosier, Philip S.

“…The zebrafish is increasingly being utilized to study aspects of the conserved innate intestinal immunity of vertebrates. In mammals, some antimicrobial…”
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Zebrafish runx1 promoter-EGFP transgenics mark discrete sites of definitive blood progenitors by Yi Ni Lam, Enid, Chau, Jackie Y.M., Kalev-Zylinska, Maggie L., Fountaine, Timothy M., Mead, R. Scott, Hall, Christopher J., Crosier, Philip S., Crosier, Kathryn E., Vega Flores, Maria

“…The transcription factor Runx1 is essential for the development of definitive hematopoietic stem cells (HSCs) during vertebrate embryogenesis and is…”
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Runx3 is required for hematopoietic development in zebrafish by Kalev‐Zylinska, Maggie L., Horsfield, Julia A., Flores, Maria Vega C., Postlethwait, John H., Chau, Jackie Y.M., Cattin, Peter M., Vitas, Maria R., Crosier, Philip S., Crosier, Kathryn E.

“…We cloned zebrafish runx3/aml2/cbfa3 and examined its expression and function during embryogenesis. In the developing embryo, runx3 is dynamically expressed in…”
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Intestinal Differentiation in Zebrafish Requires Cdx1b, a Functional Equivalent of Mammalian Cdx2 by Flores, Maria Vega C, Hall, Chris J, Davidson, Alan J, Singh, Primal P, Mahagaonkar, Alhad A, Zon, Leonard I, Crosier, Kathryn E, Crosier, Philip S

“…Background & Aims The ParaHox transcription factor Cdx2 is an essential determinant of intestinal phenotype in mammals throughout development, influencing gut…”
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Duplicate zebrafish runx2 orthologues are expressed in developing skeletal elements by Flores, Maria Vega, Tsang, Vicky Wai Kei, Hu, Wenjue, Kalev-Zylinska, Maggie, Postlethwait, John, Crosier, Philip, Crosier, Kathryn, Fisher, Shannon

“…The differentiation of cells in the vertebrate skeleton is controlled by a precise genetic program. One crucial regulatory gene in the pathway encodes the…”
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Radar Is Required for the Establishment of Vascular Integrity in the Zebrafish by Hall, Christopher J., Flores, Maria Vega C., Davidson, Alan J., Crosier, Kathryn E., Crosier, Philip S.

“…The precise assembly of an integrated network of blood vessels is essential for the survival of vertebrate embryos. However, the processes by which primitive…”
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