Search Results - "Flores, Juana M."

G6PD protects from oxidative damage and improves healthspan in mice by Nóbrega-Pereira, Sandrina, Fernandez-Marcos, Pablo J., Brioche, Thomas, Gomez-Cabrera, Mari Carmen, Salvador-Pascual, Andrea, Flores, Juana M., Viña, Jose, Serrano, Manuel

“…Reactive oxygen species (ROS) are constantly generated by cells and ROS-derived damage contributes to ageing. Protection against oxidative damage largely…”
Get full text

Mice with Pulmonary Fibrosis Driven by Telomere Dysfunction by Povedano, Juan M., Martinez, Paula, Flores, Juana M., Mulero, Francisca, Blasco, Maria A.

“…Idiopathic pulmonary fibrosis (IPF) is a degenerative disease of the lungs with an average survival post-diagnosis of 2–3 years. New therapeutic targets and…”
Get full text

A mouse model for Li-Fraumeni-Like Syndrome with cardiac angiosarcomas associated to POT1 mutations by Martínez, Paula, Sánchez-Vázquez, Raúl, Ferrara-Romeo, Iole, Serrano, Rosa, Flores, Juana M., Blasco, Maria A.

“…The shelterin protein POT1 has been found mutated in many different familial and sporadic cancers, however, no mouse models to understand the pathobiology of…”
Get full text

The Rate of Increase of Short Telomeres Predicts Longevity in Mammals by Vera, Elsa, Bernardes de Jesus, Bruno, Foronda, Miguel, Flores, Juana M., Blasco, Maria A.

“…Aberrantly short telomeres result in decreased longevity in both humans and mice with defective telomere maintenance. Normal populations of humans and mice…”
Get full text

Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice by Martínez, Paula, Thanasoula, Maria, Muñoz, Purificación, Liao, Chunyan, Tejera, Agueda, McNees, Carolyn, Flores, Juana M, Fernández-Capetillo, Oscar, Tarsounas, Madalena, Blasco, Maria A

“…The telomere repeat-binding factor 1 (TERF1, referred to hereafter as TRF1) is a component of mammalian telomeres whose role in telomere biology and disease…”
Get full text

Protective Role of Hepatocyte Cyclooxygenase‐2 Expression Against Liver Ischemia–Reperfusion Injury in Mice by Motiño, Omar, Francés, Daniel E., Casanova, Natalia, Fuertes‐Agudo, Marina, Cucarella, Carme, Flores, Juana M., Vallejo‐Cremades, María Teresa, Olmedilla, Luis, Pérez Peña, José, Bañares, Rafael, Boscá, Lisardo, Casado, Marta, Martín‐Sanz, Paloma

“…Liver ischemia and reperfusion injury (IRI) remains a serious clinical problem affecting liver transplantation outcomes. IRI causes up to 10% of early organ…”
Get full text

RAP1 Protects from Obesity through Its Extratelomeric Role Regulating Gene Expression by Martínez, Paula, Gómez-López, Gonzalo, García, Fernando, Mercken, Evi, Mitchell, Sarah, Flores, Juana M., de Cabo, Rafael, Blasco, Maria A.

“…RAP1 is part of shelterin, the protective complex at telomeres. RAP1 also binds along chromosome arms, where it is proposed to regulate gene expression. To…”
Get full text

Telomerase reverse transcriptase synergizes with calorie restriction to increase health span and extend mouse longevity by Vera, Elsa, Bernardes de Jesus, Bruno, Foronda, Miguel, Flores, Juana M, Blasco, Maria A

“…Caloric restriction (CR), a reduction of food intake while avoiding malnutrition, can delay the onset of cancer and age-related diseases in several species,…”
Get full text

SNAI1 Is Required for Tumor Growth and Lymph Node Metastasis of Human Breast Carcinoma MDA-MB-231 Cells by OLMEDA, David, MORENO-BUENO, Gema, FLORES, Juana M, FABRA, Angels, PORTILLO, Francisco, CANO, Amparo

“…The transcription factor, SNAI1 (Snail), has recently been proposed as an important mediator of tumor invasion because of its role in E-cadherin…”
Get full text

Cannabinoids reduce ErbB2-driven breast cancer progression through Akt inhibition by Caffarel, María M, Andradas, Clara, Mira, Emilia, Pérez-Gómez, Eduardo, Cerutti, Camilla, Moreno-Bueno, Gema, Flores, Juana M, García-Real, Isabel, Palacios, José, Mañes, Santos, Guzmán, Manuel, Sánchez, Cristina

“…ErbB2-positive breast cancer is characterized by highly aggressive phenotypes and reduced responsiveness to standard therapies. Although specific…”
Get full text

SOX9 promotes tumor progression through the axis BMI1-p21CIP by Aldaz, Paula, Otaegi-Ugartemendia, Maddalen, Saenz-Antoñanzas, Ander, Garcia-Puga, Mikel, Moreno-Valladares, Manuel, Flores, Juana M., Gerovska, Daniela, Arauzo-Bravo, Marcos J., Samprón, Nicolas, Matheu, Ander, Carrasco-Garcia, Estefania

“…The developmental regulator SOX9 is linked to cancer progression mainly as a result of its role in the regulation of cancer stem cells (CSCs). However, its…”
Get full text

A genetic interaction between RAP1 and telomerase reveals an unanticipated role for RAP1 in telomere maintenance by Martínez, Paula, Gómez‐López, Gonzalo, Pisano, David G., Flores, Juana M., Blasco, Maria A.

“…Summary RAP1 is one of the components of shelterin, the capping complex at chromosome ends or telomeres, although its role in telomere length maintenance and…”
Get full text

Sox4 Links Tumor Suppression to Accelerated Aging in Mice by Modulating Stem Cell Activation by Foronda, Miguel, Martínez, Paula, Schoeftner, Stefan, Gómez-López, Gonzalo, Schneider, Ralph, Flores, Juana M., Pisano, David G., Blasco, Maria A.

“…Sox4 expression is restricted in mammals to embryonic structures and some adult tissues, such as lymphoid organs, pancreas, intestine, and skin. During…”
Get full text

Telomerase abrogation dramatically accelerates TRF2-induced epithelial carcinogenesis by Blanco, Raquel, Muñoz, Purificación, Flores, Juana M, Klatt, Peter, Blasco, María A

“…TRF2 is a telomere-binding protein with roles in telomere protection and telomere-length regulation. The fact that TRF2 is up-regulated in some human tumors…”
Get full text

Therapeutic inhibition of TRF1 impairs the growth of p53‐deficient K‐RasG12V‐induced lung cancer by induction of telomeric DNA damage by García‐Beccaria, María, Martínez, Paula, Méndez‐Pertuz, Marinela, Martínez, Sonia, Blanco‐Aparicio, Carmen, Cañamero, Marta, Mulero, Francisca, Ambrogio, Chiara, Flores, Juana M, Megias, Diego, Barbacid, Mariano, Pastor, Joaquín, Blasco, Maria A

“…Telomeres are considered anti‐cancer targets, as telomere maintenance above a minimum length is necessary for cancer growth. Telomerase abrogation in…”
Get full text

The Atypical PKC-Interacting Protein p62 Is an Important Mediator of RANK-Activated Osteoclastogenesis by Durán, Angeles, Serrano, Manuel, Leitges, Michael, Flores, Juana M, Picard, Sylvain, Brown, Jacques P, Moscat, Jorge, Diaz-Meco, Maria T

“…The atypical PKCs (aPKCs) have been implicated genetically in at least two independent signaling cascades that control NF-κB and cell polarity, through the…”
Get full text

Anti‐aging activity of the Ink4/Arf locus by Matheu, Ander, Maraver, Antonio, Collado, Manuel, Garcia‐Cao, Isabel, Cañamero, Marta, Borras, Consuelo, Flores, Juana M., Klatt, Peter, Viña, Jose, Serrano, Manuel

“…Summary The proteins encoded by the Ink4/Arf locus, p16Ink4a, p19Arf and p15Ink4b are major tumour suppressors that oppose aberrant mitogenic signals. The…”
Get full text

NOD1 activation induces cardiac dysfunction and modulates cardiac fibrosis and cardiomyocyte apoptosis by Fernández-Velasco, María, Prieto, Patricia, Terrón, Verónica, Benito, Gemma, Flores, Juana M, Delgado, Carmen, Zaragoza, Carlos, Lavin, Begoña, Gómez-Parrizas, Mónica, López-Collazo, Eduardo, Martín-Sanz, Paloma, Boscá, Lisardo

“…The innate immune system is responsible for the initial response of an organism to potentially harmful stressors, pathogens or tissue injury, and accordingly…”
Get full text

Growth Arrest Specific 1 (Gas1) Gene Overexpression in Liver Reduces the In Vivo Progression of Murine Hepatocellular Carcinoma and Partially Restores Gene Expression Levels by Sacilotto, Natalia, Castillo, Josefa, Riffo-Campos, Ángela L, Flores, Juana M, Hibbitt, Olivia, Wade-Martins, Richard, López, Carlos, Rodrigo, M Isabel, Franco, Luis, López-Rodas, Gerardo

“…The prognosis of hepatocellular carcinoma patients is usually poor, the size of tumors being a limiting factor for surgical treatments. Present results suggest…”
Get full text

TRF1 Controls Telomere Length and Mitotic Fidelity in Epithelial Homeostasis by Muñoz, Purificacion, Blanco, Raquel, de Carcer, Guillermo, Schoeftner, Stefan, Benetti, Roberta, Flores, Juana M., Malumbres, Marcos, Blasco, Maria A.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text