Search Results - "Florens, Laurence"

The methyltransferase SETD2 couples transcription and splicing by engaging mRNA processing factors through its SHI domain by Bhattacharya, Saikat, Levy, Michaella J., Zhang, Ning, Li, Hua, Florens, Laurence, Washburn, Michael P., Workman, Jerry L.

“…Heterogeneous ribonucleoproteins (hnRNPs) are RNA binding molecules that are involved in key processes such as RNA splicing and transcription. One such hnRNP…”
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DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly by Litovchick, Larisa, Florens, Laurence A, Swanson, Selene K, Washburn, Michael P, DeCaprio, James A

“…In the absence of growth signals, cells exit the cell cycle and enter into G0 or quiescence. Alternatively, cells enter senescence in response to inappropriate…”
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Characterization of Human Cyclin-Dependent Kinase 12 (CDK12) and CDK13 Complexes in C-Terminal Domain Phosphorylation, Gene Transcription, and RNA Processing by Liang, Kaiwei, Gao, Xin, Gilmore, Joshua M., Florens, Laurence, Washburn, Michael P., Smith, Edwin, Shilatifard, Ali

“…Cyclin-dependent kinase 9 (CDK9) and CDK12 have each been demonstrated to phosphorylate the RNA polymerase II C-terminal domain (CTD) at serine 2 of the heptad…”
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The human cytoplasmic dynein interactome reveals novel activators of motility by Redwine, William B, DeSantis, Morgan E, Hollyer, Ian, Htet, Zaw Min, Tran, Phuoc Tien, Swanson, Selene K, Florens, Laurence, Washburn, Michael P, Reck-Peterson, Samara L

“…In human cells, cytoplasmic dynein-1 is essential for long-distance transport of many cargos, including organelles, RNAs, proteins, and viruses, towards…”
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The Integrator complex controls the termination of transcription at diverse classes of gene targets by Skaar, Jeffrey R, Ferris, Andrea L, Wu, Xiaolin, Saraf, Anita, Khanna, Kum Kum, Florens, Laurence, Washburn, Michael P, Hughes, Stephen H, Pagano, Michele

“…Complexes containing INTS3 and either NABP1 or NABP2 were initially characterized in DNA damage responses, but their biochemical function remained unknown…”
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Dynamic RNA acetylation revealed by quantitative cross-evolutionary mapping by Sas-Chen, Aldema, Thomas, Justin M., Matzov, Donna, Taoka, Masato, Nance, Kellie D., Nir, Ronit, Bryson, Keri M., Shachar, Ran, Liman, Geraldy L. S., Burkhart, Brett W., Gamage, Supuni Thalalla, Nobe, Yuko, Briney, Chloe A., Levy, Michaella J., Fuchs, Ryan T., Robb, G. Brett, Hartmann, Jesse, Sharma, Sunny, Lin, Qishan, Florens, Laurence, Washburn, Michael P., Isobe, Toshiaki, Santangelo, Thomas J., Shalev-Benami, Moran, Meier, Jordan L., Schwartz, Schraga

“…N 4 -acetylcytidine (ac 4 C) is an ancient and highly conserved RNA modification that is present on tRNA and rRNA and has recently been investigated in…”
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The ULK1-FBXW5-SEC23B nexus controls autophagy by Jeong, Yeon-Tae, Simoneschi, Daniele, Keegan, Sarah, Melville, David, Adler, Natalia S, Saraf, Anita, Florens, Laurence, Washburn, Michael P, Cavasotto, Claudio N, Fenyö, David, Cuervo, Ana Maria, Rossi, Mario, Pagano, Michele

“…In response to nutrient deprivation, the cell mobilizes an extensive amount of membrane to form and grow the autophagosome, allowing the progression of…”
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A putative cap binding protein and the methyl phosphate capping enzyme Bin3/MePCE function in telomerase biogenesis by Páez-Moscoso, Diego J., Ho, David V., Pan, Lili, Hildebrand, Katie, Jensen, Kristi L., Levy, Michaella J., Florens, Laurence, Baumann, Peter

“…Telomerase reverse transcriptase (TERT) and the noncoding telomerase RNA (TR) subunit constitute the core of telomerase. Additional subunits are required for…”
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Merkel cell polyomavirus activates LSD1-mediated blockade of non-canonical BAF to regulate transformation and tumorigenesis by Park, Donglim Esther, Cheng, Jingwei, McGrath, John P., Lim, Matthew Y., Cushman, Camille, Swanson, Selene K., Tillgren, Michelle L., Paulo, Joao A., Gokhale, Prafulla C., Florens, Laurence, Washburn, Michael P., Trojer, Patrick, DeCaprio, James A.

“…Merkel cell carcinoma (MCC)—a neuroendocrine cancer of the skin—is caused by the integration of Merkel cell polyomavirus and persistent expression of large T…”
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Structural basis of the interaction between SETD2 methyltransferase and hnRNP L paralogs for governing co-transcriptional splicing by Bhattacharya, Saikat, Wang, Suman, Reddy, Divya, Shen, Siyuan, Zhang, Ying, Zhang, Ning, Li, Hua, Washburn, Michael P., Florens, Laurence, Shi, Yunyu, Workman, Jerry L., Li, Fudong

“…The RNA recognition motif (RRM) binds to nucleic acids as well as proteins. More than one such domain is found in the pre-mRNA processing hnRNP proteins. While…”
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Topological scoring of protein interaction networks by Sardiu, Mihaela E., Gilmore, Joshua M., Groppe, Brad D., Dutta, Arnob, Florens, Laurence, Washburn, Michael P.

“…It remains a significant challenge to define individual protein associations within networks where an individual protein can directly interact with other…”
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Mediator structure and rearrangements required for holoenzyme formation by Tsai, Kuang-Lei, Yu, Xiaodi, Gopalan, Sneha, Chao, Ti-Chun, Zhang, Ying, Florens, Laurence, Washburn, Michael P., Murakami, Kenji, Conaway, Ronald C., Conaway, Joan W., Asturias, Francisco J.

“…The conserved Mediator co-activator complex has an essential role in the regulation of RNA polymerase II transcription in all eukaryotes. Understanding the…”
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Histone H3 lysine-to-methionine mutants as a paradigm to study chromatin signaling by Herz, Hans-Martin, Morgan, Marc, Gao, Xin, Jackson, Jessica, Rickels, Ryan, Swanson, Selene K., Florens, Laurence, Washburn, Michael P., Eissenberg, Joel C., Shilatifard, Ali

“…Histone H3 lysine27-to-methionine (H3K27M) gain-of-function mutations occur in highly aggressive pediatric gliomas. We established a Drosophila animal model…”
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AFF4, a Component of the ELL/P-TEFb Elongation Complex and a Shared Subunit of MLL Chimeras, Can Link Transcription Elongation to Leukemia by Lin, Chengqi, Smith, Edwin R., Takahashi, Hidehisa, Lai, Ka Chun, Martin-Brown, Skylar, Florens, Laurence, Washburn, Michael P., Conaway, Joan W., Conaway, Ronald C., Shilatifard, Ali

“…Chromosomal translocations involving the MLL gene are associated with infant acute lymphoblastic and mixed lineage leukemia. There are a large number of…”
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Chromatin remodelers Isw1 and Chd1 maintain chromatin structure during transcription by preventing histone exchange by Smolle, Michaela, Venkatesh, Swaminathan, Gogol, Madelaine M, Li, Hua, Zhang, Ying, Florens, Laurence, Washburn, Michael P, Workman, Jerry L

“…The histone H3K36 methylation mark is associated with coding regions of actively transcribed genes, yet it plays a negative role during transcription…”
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The mRNA-bound proteome of the human malaria parasite Plasmodium falciparum by Bunnik, Evelien M, Batugedara, Gayani, Saraf, Anita, Prudhomme, Jacques, Florens, Laurence, Le Roch, Karine G

“…Gene expression is controlled at multiple levels, including transcription, stability, translation, and degradation. Over the years, it has become apparent that…”
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Cyclin F-Mediated Degradation of Ribonucleotide Reductase M2 Controls Genome Integrity and DNA Repair by D'Angiolella, Vincenzo, Donato, Valerio, Forrester, Frances M., Jeong, Yeon-Tae, Pellacani, Claudia, Kudo, Yasusei, Saraf, Anita, Florens, Laurence, Washburn, Michael P., Pagano, Michele

“…F-box proteins are the substrate binding subunits of SCF (Skp1-Cul1-F-box protein) ubiquitin ligase complexes. Using affinity purifications and mass…”
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Functional genomics of RAP proteins and their role in mitoribosome regulation in Plasmodium falciparum by Hollin, Thomas, Abel, Steven, Falla, Alejandra, Pasaje, Charisse Flerida A., Bhatia, Anil, Hur, Manhoi, Kirkwood, Jay S., Saraf, Anita, Prudhomme, Jacques, De Souza, Amancio, Florens, Laurence, Niles, Jacquin C., Le Roch, Karine G.

“…The RAP (RNA-binding domain abundant in Apicomplexans) protein family has been identified in various organisms. Despite expansion of this protein family in…”
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STRIPAK directs PP2A activity toward MAP4K4 to promote oncogenic transformation of human cells by Kim, Jong Wook, Berrios, Christian, Kim, Miju, Schade, Amy E, Adelmant, Guillaume, Yeerna, Huwate, Damato, Emily, Iniguez, Amanda Balboni, Florens, Laurence, Washburn, Michael P, Stegmaier, Kim, Gray, Nathanael S, Tamayo, Pablo, Gjoerup, Ole, Marto, Jarrod A, DeCaprio, James, Hahn, William C

“…Alterations involving serine-threonine phosphatase PP2A subunits occur in a range of human cancers, and partial loss of PP2A function contributes to cell…”
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SCFCyclin F controls centrosome homeostasis and mitotic fidelity through CP110 degradation by D’Angiolella, Vincenzo, Donato, Valerio, Vijayakumar, Sangeetha, Saraf, Anita, Florens, Laurence, Washburn, Michael P., Dynlacht, Brian, Pagano, Michele

“…A role for Cyclin F Cyclin F is the founding member of the F-box protein family but its functions are unknown. In contrast to most cyclins, it does not bind or…”
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