Search Results - "Florence, Gordon"

Approaches to CNS Drug Delivery with a Focus on Transporter-Mediated Transcytosis by Abdul Razzak, Rana, Florence, Gordon J, Gunn-Moore, Frank J

“…Drug delivery to the central nervous system (CNS) conferred by brain barriers is a major obstacle in the development of effective neurotherapeutics. In this…”
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The trypanosome alternative oxidase: a potential drug target? by Menzies, Stefanie K, Tulloch, Lindsay B, Florence, Gordon J, Smith, Terry K

“…New drugs against Trypanosoma brucei, the causative agent of Human African Trypanosomiasis, are urgently needed to replace the highly toxic and largely…”
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Photo-affinity labelling and biochemical analyses identify the target of trypanocidal simplified natural product analogues by Tulloch, Lindsay B, Menzies, Stefanie K, Fraser, Andrew L, Gould, Eoin R, King, Elizabeth F, Zacharova, Marija K, Florence, Gordon J, Smith, Terry K

“…Current drugs to treat African sleeping sickness are inadequate and new therapies are urgently required. As part of a medicinal chemistry programme based upon…”
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Synthesis of the Originally Proposed Structure of Palmerolide C by Florence, Gordon J., Wlochal, Joanna

“…A stereoselective synthesis of the proposed structure of palmerolide C (1), a cytotoxic marine macrolide isolated from the Antarctic tunicate Synoicum…”
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The "Calculus" of Moving Averages by Gordon, Sheldon P., Gordon, Florence S.

“…This article makes a case for introducing moving averages into introductory statistics courses and contemporary modeling/data-based courses in college algebra…”
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Direct and indirect approaches to identify drug modes of action by Tulloch, Lindsay B., Menzies, Stefanie K., Coron, Ross P., Roberts, Matthew D., Florence, Gordon J., Smith, Terry K.

“…Phenotypic assays are becoming increasingly more common among drug discovery practices, expanding drug target diversity as lead compounds identified through…”
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Development of practical syntheses of the marine anticancer agents discodermolide and dictyostatin by Florence, Gordon J, Gardner, Nicola M, Paterson, Ian

“…Initially isolated in trace quantities from deep-sea sponges, the structurally related polyketides discodermolide and dictyostatin share the same…”
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The Identification and Heterologous Expression of the Biosynthetic Gene Cluster Encoding the Antibiotic and Anticancer Agent Marinomycin by Abraham, Emily, Lawther, Hannah A, Wang, Yunpeng, Zarins-Tutt, Joseph S, Rivera, Gerry Sann, Wu, Chengcang, Connolly, Jack A, Florence, Gordon, Agbo, Matthias, Gao, Hong, Goss, Rebecca J M

“…With the rise in antimicrobial resistance, there is an urgent need for new classes of antibiotic with which to treat infectious disease. Marinomycin, a polyene…”
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Simplifying nature: Towards the design of broad spectrum kinetoplastid inhibitors, inspired by acetogenins by Gould, Eoin R., King, Elizabeth F.B., Menzies, Stefanie K., Fraser, Andrew L., Tulloch, Lindsay B., Zacharova, Marija K., Smith, Terry K., Florence, Gordon J.

“…[Display omitted] The need for new treatments for the neglected tropical diseases African sleeping sickness, Chagas disease and Leishmaniasis remains urgent…”
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Incorporating Statistics into College Algebra by Gordon, Sheldon P, Gordon, Florence S

“…The authors discuss the status of college algebra and related offerings and their relationship to introductory statistics education. They also describe an…”
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An internal thioester in a pathogen surface protein mediates covalent host binding by Walden, Miriam, Edwards, John M, Dziewulska, Aleksandra M, Bergmann, Rene, Saalbach, Gerhard, Kan, Su-Yin, Miller, Ona K, Weckener, Miriam, Jackson, Rosemary J, Shirran, Sally L, Botting, Catherine H, Florence, Gordon J, Rohde, Manfred, Banfield, Mark J, Schwarz-Linek, Ulrich

“…To cause disease and persist in a host, pathogenic and commensal microbes must adhere to tissues. Colonization and infection depend on specific molecular…”
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Structure‐Based Design, Synthesis and Biological Evaluation of Bis‐Tetrahydropyran Furan Acetogenin Mimics Targeting the Trypanosomatid F1 Component of ATP Synthase by Zacharova, Marija K., Tulloch, Lindsay B., Gould, Eoin R., Fraser, Andrew L., King, Elizabeth F., Menzies, Stefanie K., Smith, Terry K., Florence, Gordon J.

“…The protozoan parasites Trypanosoma brucei, Trypanosoma cruzi and Leishmania spp. are responsible for the severely debilitating neglected Tropical diseases of…”
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Catalytic and Anticatalytic Snapshots of a Short-Form ATP Phosphoribosyltransferase by Alphey, Magnus S, Fisher, Gemma, Ge, Ying, Gould, Eoin R, Machado, Teresa F. G, Liu, Huanting, Florence, Gordon J, Naismith, James H, da Silva, Rafael G

“…Allosteric modulation of catalysis is a common regulatory strategy of flux-controlling biosynthetic enzymes. The enzyme ATP phosphoribosyltransferase (ATPPRT)…”
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Studies towards the synthesis of neopeltolide: synthesis of a ring-closing metathesis macrocyclization precursor by Florence, Gordon J., Cadou, Romain F.

“…An advanced ring-closing metathesis precursor for the synthesis of the marine macrolide neopeltolide is prepared in a stereocontrolled manner by the coupling…”
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Visualizing and Understanding Hypothesis Testing Using Dynamic Software by Gordon, Sheldon P., Gordon, Florence S.

“…This article illustrates ways that dynamic software using some sophisticated techniques in Excel can be used to demonstrate fundamental ideas related to…”
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Kinetics and Structure of a Cold-Adapted Hetero-Octameric ATP Phosphoribosyltransferase by Stroek, Rozanne, Ge, Ying, Talbot, Paul D, Glok, Mateusz K, Bernaś, Klaudia E, Thomson, Catherine M, Gould, Eoin R, Alphey, Magnus S, Liu, Huanting, Florence, Gordon J, Naismith, James H, da Silva, Rafael G

“…Adenosine 5′-triphosphate phosphoribosyltransferase (ATPPRT) catalyzes the first step in histidine biosynthesis, the condensation of ATP and…”
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Total Synthesis of (−)-Reidispongiolide A, an Actin-Targeting Marine Macrolide by Paterson, Ian, Ashton, Kate, Britton, Robert, Cecere, Giuseppe, Chouraqui, Gaëlle, Florence, Gordon J., Stafford, Jonathan

“…Actin class: A stereoselective synthesis of the microfilament‐destabilizing cytotoxic macrolide (−)‐reidispongiolide A, isolated from the marine sponge…”
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The Development of a Practical Total Synthesis of Discodermolide, a Promising Microtubule-Stabilizing Anticancer Agent by Paterson, Ian, Florence, Gordon J.

“…Marine organisms provide an important source of natural product diversity with an associated range of significant biological activities. Discodermolide,…”
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Total Synthesis, Stereochemical Assignment, and Biological Activity of Chamuvarinin and Structural Analogues by Florence, Gordon J., Morris, Joanne C., Murray, Ross G., Vanga, Raghava R., Osler, Jonathan D., Smith, Terry K.

“…A highly stereocontrolled synthesis of (+)‐chamuvarinin has been completed in 1.5 % overall yield over 20 steps. The key fragment coupling reactions were the…”
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Visualizing and Understanding Sampling Distributions Using Dynamic Software by Gordon, Sheldon P, Gordon, Florence S

“…This article illustrates ways that dynamic software using some sophisticated techniques in Excel can be used to demonstrate fundamental ideas related to…”
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